Search results for "2R"
showing 10 items of 93 documents
CCDC 1982668: Experimental Crystal Structure Determination
2023
Related Article: Antonin Jaillet, Christophe Darcel, Jérôme Bayardon, Adrien Schlachter, Christine Salomon, Yoann Rousselin, Pierre Harvey, Sylvain Jugé|2020|J.Org.Chem.|85|14391|doi:10.1021/acs.joc.0c00536
Self-phase modulation-based 2R regenerator including pulse compression and offset filtering for 42.6 Gbit/s RZ-33% transmission systems
2009
International audience; We report on the experimental and theoretical study of a self-phase-modulation-based regenerator at 42.6 Gbit/s with a return-to-zero 33% format. We point out some detrimental effects such as intrachannel interactions and Brillouin scattering. An efficient solution, relying on a self-phase-modulation-based pulse compressor in combination with the regenerator, is proposed to overcome these detrimental phenomena. The experimental demonstration shows the effectiveness of a wavelength-transparent regenerator at 42.6 Gbit/s with a sensitivity-improvement of more than 5 dB and an eye-opening improvement of 2.3 dB in a back-to-back configuration, as well as a 10 times maxim…
Integration, Bewertung und Nutzung heterogener Datenquellen mittels semantischer Werkzeuge
2017
In diesem Artikel stellen wir unsere Forschung in der Integration von Geodaten in einen Semantic Web Kontext in unserem Projekt Semantic GIS vor. Zunächst möchten wir den Zweck und die Vorteile einer Integration und Interpretation von Daten in das Semantic Web beleuchten und anschließend unseren Integrationprozess bestehend aus Datengewin-nung, automatischer Interpretation, Qualitätssicherung und Provenance sowie den Datenzugriff erklären. Um die Anwendung unserer Forschung zu demonstrieren gehen wir auf zwei Anwendungsfälle in unserem Projekt ein: Die Bewertung von OpenStreetMap Daten und die Verbesserung des Katastrophenschutzes mittels semantischem Reasoning. Wir schließen den Artikel mi…
Global and sex-specific epigenome-wide association studies for the identification of the main methylated loci related to smoking in a mediterranean p…
2019
Abstract Background Tobacco use has been reported to be the main cause of 90% of male and 80% of female lung cancers, as well as a relevant risk factor for other cancers such as oropharynx, larynx, esophagus, stomach, liver, pancreas, kidney, bladder, and colorectum. Smoking directly affects DNA methylation and although several genes have been reported to be differentially methylated in smokers, gender differences and population-specific differences remain to be further investigated. Our aim was to undertake global and sex-specific genome-wide epigenomic studies (EWAS) in a Mediterranean population to identify the main smoking DNA-methylated genes. Methods We analyzed 88 participants in the…
Generation of localized pulses from incoherent wave in optical fiber lines made of concatenated Mamyshev regenerators
2008
International audience; We investigate the novel properties of optical fiber lines made of Mamyshev regenerators (MRs) based on self-phase modulation and subsequent spectral filtering. In particular, we show that such a regenerator line can be used to generate random sequences of optical pulses from an incoherent wave. This behavior is related to the existence of stable eigenpulses that can propagate unchanged through the regenerator line and act as attractors for incoming pulses. By changing the regenerator parameters, we also report the existence of multiple eigenpulses and limit cycles. Finally, we demonstrate that MRs could be used as efficient nonlinear gates in fiber laser cavities.
Cost-Effectiveness Analysis: Stress Ulcer Bleeding Prophylaxis with Proton Pump Inhibitors, H2 Receptor Antagonists
2012
Abstract Objectives Proton pump inhibitors (PPIs) and H2-receptor antagonists (H2RAs) present varying pharmacological efficacy in preventing stress ulcer bleeding (SUB) in intensive care units. The literature also reports disparate rates of ventilator-assisted pneumonia (VAP) as side effects of these treatments. We compared the cost-effectiveness of these two prophylactic pharmacological options. Methods We constructed a decision tree with a 60-day time horizon for patients at high risk for developing SUB, receiving either PPIs or H2RAs. For each treatment strategy, patients could be in one of three states of health: SUB, VAP, or no complication. Contemporary, clinically relevant probabilit…
Development of [1,2]oxazoloisoindoles tubulin polymerization inhibitors: Further chemical modifications and potential therapeutic effects against lym…
2022
Lymphomas are among the ten most common cancers, and, although progress has been achieved in increasing survival, there is still an unmet need for more effective therapeutic approaches, including better options for patients with refractory tumors that initially respond but then relapse. The lack of effective alternative treatment options highlights the need to develop new therapeutic strategies capable of improving survival prospects for lymphoma patients. Herein, we describe the identification and exploration of the SAR of a series of [1,2]oxazolo[5,4-e]isoindoles as potent small molecules that bind to the colchicine site of tubulin and that have promise for the treatment of refractory lym…
Longitudinal CSF proteome profiling in mice to uncover the acute and sustained mechanisms of action of rapid acting antidepressant (2R,6R)-hydroxynor…
2021
Delayed onset of antidepressant action is a shortcoming in depression treatment. Ketamine and its metabolite (2R,6R)-hydroxynorketamine (HNK) have emerged as promising rapid-acting antidepressants. However, their mechanism of action remains unknown. In this study, we first described the anxious and depression-prone inbred mouse strain, DBA/2J, as an animal model to assess the antidepressant-like effects of ketamine and HNK in vivo. To decode the molecular mechanisms mediating HNK's rapid antidepressant effects, a longitudinal cerebrospinal fluid (CSF) proteome profiling of its acute and sustained effects was conducted using an unbiased, hypothesis-free mass spectrometry-based proteomics app…
Vizuāli semantiski vaicājumi pār relāciju datubāzēm
2020
Korektu vaicājumu izveide ir svarīgākais posms datu izguves procesā. Konstruējot vaicājumu vizuāli, tiek sniegta iespēja iegūt korektus datus ne tikai jomas speciālistiem, bet arī citu profesiju pārstāvjiem bez specifiskām tekstuālās vaicājuma valodas sintakses zināšanām. Dažādas vaicājumu bāzētas valodas kā SPARQL tiek izmantotas, lai iegūtu datus no semantiskā tīmekļa, bet, izmantojot minēto vaicājumu valodu, nav iespējams tieši izgūt datus no relāciju datubāzēm. Ontoloģijā bāzēta datu piekļuve ir kļuvusi par populāru pieeju lielo datu laikmetā. Darbā tiek apskatīta iespēja OBDA pieejas ietvaros veikt vizuāli semantisku vaicājumu izpildi, pār relāciju datubāzēm izmantojot R2RML. Izmantojo…