Search results for "3'"

showing 10 items of 589 documents

Genetic 3’UTR variation is associated with human pigmentation characteristics and sensitivity to sunlight

2017

Sunlight exposure induces signalling pathways leading to the activation of melanin synthesis and tanning response. MicroRNAs (miRNAs) can regulate the expression of genes involved in pigmentation pathways by binding to the complementary sequence in their 3'untranslated regions (3'UTRs). Therefore, 3'UTR SNPs are predicted to modify the ability of miRNAs to target genes, resulting in differential gene expression. In this study, we investigated the role in pigmentation and sun-sensitivity traits, as well as in melanoma susceptibility, of 38 different 3'UTR SNPs from 38 pigmentation-related genes. A total of 869 individuals of Spanish origin (526 melanoma cases and 343 controls) were analysed.…

0301 basic medicineSkin NeoplasmsSNPSingle-nucleotide polymorphismSkin PigmentationDermatologyBiologyBiochemistryPolymorphism Single NucleotideWhite People03 medical and health sciencesGene FrequencyRisk FactorsWnt3A ProteinmicroRNAGene expressionGenotypeSNPHumansGenetic Predisposition to DiseasePhotosensitivity DisordersRNA MessengerHair ColorNaevusMolecular BiologyGene3' Untranslated RegionsMelanomaSolar lentiginesAdaptor Proteins Signal TransducingGeneticsLentigoBinding SitesEye ColorThree prime untranslated regionMicroRNAProtective Factors3' untranslated regionPhenotypeMicroRNAs030104 developmental biologyPhenotypeSpainCase-Control Studies
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MicroRNAs miR-19, miR-340, miR-374 and miR-542 regulate MID1 protein expression.

2018

The MID1 ubiquitin ligase activates mTOR signaling and regulates mRNA translation. Misregulation of MID1 expression is associated with various diseases including midline malformation syndromes, cancer and neurodegenerative diseases. While this indicates that MID1 expression must be tightly regulated to prevent disease states specific mechanisms involved have not been identified. We examined miRNAs to determine mechanisms that regulate MID1 expression. MicroRNAs (miRNA) are small non-coding RNAs that recognize specific sequences in their target mRNAs. Upon binding, miRNAs typically downregulate expression of these targets. Here, we identified four miRNAs, miR-19, miR-340, miR-374 and miR-542…

0301 basic medicineUntranslated regionSmall interfering RNAPhysiologymetabolism [Microtubule Proteins]Alzheimer's DiseaseBiochemistryImmune PhysiologyMedicine and Health SciencesSmall interfering RNAsmetabolism [Transcription Factors]3' Untranslated RegionsImmune System ProteinsMultidisciplinarybiologyReverse Transcriptase Polymerase Chain ReactionMessenger RNAQRNuclear ProteinsNeurodegenerative DiseasesTranslation (biology)EnzymesUbiquitin ligaseCell biologyNucleic acidsNeurologyMicrotubule ProteinsMedicineOxidoreductasesLuciferasemetabolism [Nuclear Proteins]Research ArticleScienceUbiquitin-Protein LigasesImmunologyTransfectionResearch and Analysis MethodsReal-Time Polymerase Chain ReactionAntibodies03 medical and health sciencesMental Health and PsychiatrymicroRNAGeneticsHumansddc:610Non-coding RNAMolecular Biology TechniquesMolecular BiologyMessenger RNABiology and life sciencesThree prime untranslated regionHEK 293 cellsProteinsGene regulationphysiology [MicroRNAs]MicroRNAs030104 developmental biologyHEK293 CellsEnzymologybiology.proteinRNAProtein TranslationDementiaGene expressionTranscription FactorsMid1 protein human
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ceRNA Network Regulation of TGF-β, WNT, FOXO, Hedgehog Pathways in the Pharynx of Ciona robusta

2021

The transforming growth factor-β (TGF-β) family of cytokines performs a multifunctional signaling, which is integrated and coordinated in a signaling network that involves other pathways, such as Wintless, Forkhead box-O (FOXO) and Hedgehog and regulates pivotal functions related to cell fate in all tissues. In the hematopoietic system, TGF-β signaling controls a wide spectrum of biological processes, from immune system homeostasis to the quiescence and self-renewal of hematopoietic stem cells (HSCs). Recently an important role in post-transcription regulation has been attributed to two type of ncRNAs: microRNAs and pseudogenes. Ciona robusta, due to its philogenetic position close to verte…

0301 basic medicineascidianpseudogenepseudogeneslcsh:ChemistryTransforming Growth Factor betaProtein Interaction MappingHomeostasisRNA-Seqlcsh:QH301-705.53' Untranslated RegionsSpectroscopyTissue homeostasisForkhead Box Protein O1Wnt signaling pathwayHigh-Throughput Nucleotide Sequencingvirus diseasesGeneral Medicinefemale genital diseases and pregnancy complicationsComputer Science ApplicationsCell biologyNGSStem cellTGF-βCell fate determinationBiologyCatalysisArticleInorganic ChemistryWNT03 medical and health sciencesmicroRNAAnimalsCell LineageHedgehog ProteinsTGF-Physical and Theoretical ChemistryMolecular BiologyHedgehogneoplasmsmiRNA030102 biochemistry & molecular biologyCompeting endogenous RNAOrganic ChemistryfungiComputational BiologyHematopoiesisWnt ProteinsMicroRNAs030104 developmental biologylcsh:Biology (General)lcsh:QD1-999Gene Expression RegulationImmune SystemPharynxFOXOCionaTransforming growth factorInternational Journal of Molecular Sciences
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miR-23b and miR-218 silencing increase Muscleblind-like expression and alleviate myotonic dystrophy phenotypes in mammalian models

2018

Functional depletion of the alternative splicing factors Muscleblind-like (MBNL 1 and 2) is at the basis of the neuromuscular disease myotonic dystrophy type 1 (DM1). We previously showed the efficacy of miRNA downregulation in Drosophila DM1 model. Here, we screen for miRNAs that regulate MBNL1 and MBNL2 in HeLa cells. We thus identify miR-23b and miR-218, and confirm that they downregulate MBNL proteins in this cell line. Antagonists of miR-23b and miR-218 miRNAs enhance MBNL protein levels and rescue pathogenic missplicing events in DM1 myoblasts. Systemic delivery of these “antagomiRs” similarly boost MBNL expression and improve DM1-like phenotypes, including splicing alterations, histo…

0301 basic medicinemusculoskeletal diseasesMalecongenital hereditary and neonatal diseases and abnormalitiesScienceMyoblasts SkeletalGeneral Physics and AstronomyMice TransgenicBiologyMyotonic dystrophyGeneral Biochemistry Genetics and Molecular BiologyArticleCell Line03 medical and health scienceschemistry.chemical_compoundMice0302 clinical medicineRNA interferencemicroRNAmedicineMBNL1Gene silencingAnimalsHumansMyotonic DystrophyGene SilencingRNA Messengerlcsh:ScienceMuscle Skeletal3' Untranslated RegionsMultidisciplinaryThree prime untranslated regionAlternative splicingQRNA-Binding ProteinsGeneral Chemistrymedicine.diseaseMyotoniaCell biologyUp-RegulationAlternative SplicingDisease Models AnimalMicroRNAs030104 developmental biologyPhenotypechemistrylcsh:Q030217 neurology & neurosurgeryHeLa CellsNature Communications
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CCDC 289303: Experimental Crystal Structure Determination

2007

Related Article: K.Laihia, A.Valkonen, E.Kolehmainen, A.Antonov, D.Zhukov, I.Fedosov, V.Nikiforov|2006|J.Mol.Struct.|800|100|doi:10.1016/j.molstruc.2006.03.095

11'22'5'6'7'7a'-octahydro-2-oxo-1'-nitro-2'-(4''-chlorophenyl)-spiro(3H-indole-33'-(3H)-pyrrolizine)Space GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 1014200: Experimental Crystal Structure Determination

2014

Related Article: Hai Yi, Markus Albrecht, Arto Valkonen, Kari Rissanen|2015|New J.Chem.|39|746|doi:10.1039/C4NJ01654H

11'-((22'33'55'66'-octafluorobiphenyl-44'-diyl)bis(methylene))bis-4-aza-1-azoniabicyclo[2.2.2]octane dibromideSpace GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 1405169: Experimental Crystal Structure Determination

2017

Related Article: Julien Roger, Sylviane Royer, Hélène Cattey, Aleksandr Savateev, Radomyr V. Smaliy, Aleksandr N. Kostyuk, Jean-Cyrille Hierso|2017|Eur.J.Inorg.Chem.||330|doi:10.1002/ejic.201600502

11'-bis(5H-benzo[b]phosphindol-5-yl)-33'-di-t-butylferroceneSpace GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 1877095: Experimental Crystal Structure Determination

2019

Related Article: Léa Radal, Petr Vosáhlo, Julien Roger, Hélène Cattey, Régine Amardeil, Ivana Císařová, Petr Štěpnička, Nadine Pirio, Jean‐Cyrille Hierso|2019|Eur.J.Inorg.Chem.||865|doi:10.1002/ejic.201801378

11'-di-t-butyl-3-diphenylphosphoroselenoyl-3'-carboxy-ferroceneSpace GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 1532862: Experimental Crystal Structure Determination

2017

Related Article: Emmanuel Lerayer, Patrice Renaut, Julien Roger, Nadine Pirio, Hélène Cattey, Charles H. Devillers, Dominique Lucas, Jean-Cyrille Hierso|2017|Chem.Commun.|53|6017|doi:10.1039/C7CC02469J

1-(dimesitylboranyl)-1'-((pyrrolidinyl)methyl)-33'-di-t-butylferroceneSpace GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 1018185: Experimental Crystal Structure Determination

2015

Related Article: Nazar Pidlypnyi, Sebastian Wolf, Ming Liu, Kari Rissanen, Martin Nieger, Andreas Schmidt|2014|Tetrahedron|70|8672|doi:10.1016/j.tet.2014.09.035

1-Benzyl-1111-diethyl-5-methyl-111-dihydroimidazo [2''1'':3'4'][142]diazaborolo[1'5':15]pyrrolo[23-b]pyridin-4-ium-11-ideSpace GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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