Search results for "3'"
showing 10 items of 589 documents
Myotonic dystrophy associated expanded CUG repeat muscleblind positive ribonuclear foci are not toxic to Drosophila
2005
Myotonic dystrophy type 1 is an autosomal dominant disorder associated with the expansion of a CTG repeat in the 3 0 untranslated region (UTR) of the DMPK gene. Recent data suggest that pathogenesis is predominantly mediated by a gain of function of the mutant transcript. In patients, these expanded CUG repeat-containing transcripts are sequestered into ribonuclear foci that also contain the muscleblind-like proteins. To provide further insights into muscleblind function and the pathogenesis of myotonic dystrophy, we generated Drosophila incorporating CTG repeats in the 3 0 -UTR of a reporter gene. As in patients, expanded CUG repeats form discrete ribonuclear foci in Drosophila muscle cell…
Etude du rôle du récepteur nucléaire CAR, Constitutive Androstane Receptor, dans le métabolisme des lipides et la susceptibilité à l'athérosclérose
2011
The Constitutive Androstane Receptor (CAR) belongs to the subfamily of nuclear receptors NR1. Initially described as an orphan receptor, CAR is activated by a large number of exogenous molecules and acts as a xenosensor. The activation of CAR by these ligands stimulates transcription of phase I, II and III enzymes required for the detoxification and elimination of xenobiotics. Furthermore CAR is also involved in the metabolism of endogenous molecules such as bile acids, bilirubin or thyroid hormones. CAR has recently been the subject of numerous independent studies that have highlighted his involvement in major metabolic pathways including gluconeogenesis, lipogenesis and lipoprotein metabo…
CCDC 2077805: Experimental Crystal Structure Determination
2021
Related Article: Petr Vosáhlo, Léa Radal, Marine Labonde, Ivana Císařová, Julien Roger, Nadine Pirio, Jean-Cyrille Hierso, Petr Štěpnička|2021|Organometallics|40|1934|doi:10.1021/acs.organomet.1c00244
CCDC 278947: Experimental Crystal Structure Determination
2006
Related Article: Z.Halime, S.Balieu, M.Lachkar, T.Roisnel, P.Richard, B.Boitrel|2006|Eur.J.Org.Chem.|2006|1207|doi:10.1002/ejoc.200500685
CCDC 1852850: Experimental Crystal Structure Determination
2019
Related Article: Qiang Chen, Stefan Thoms, Sven Stöttinger, Dieter Schollmeyer, Klaus Müllen, Akimitsu Narita, Thomas Basché|2019|J.Am.Chem.Soc.|141|16439|doi:10.1021/jacs.9b08320
CCDC 2089402: Experimental Crystal Structure Determination
2021
Related Article: Tuan-Anh Nguyen, Marie-Jose�� Penouilh, He��le��ne Cattey, Nadine Pirio, Paul Fleurat-Lessard, Jean-Cyrille Hierso, Julien Roger|2021|Organometallics|40|3571|doi:10.1021/acs.organomet.1c00465
CCDC 2089400: Experimental Crystal Structure Determination
2021
Related Article: Tuan-Anh Nguyen, Marie-Jose�� Penouilh, He��le��ne Cattey, Nadine Pirio, Paul Fleurat-Lessard, Jean-Cyrille Hierso, Julien Roger|2021|Organometallics|40|3571|doi:10.1021/acs.organomet.1c00465
CCDC 954557: Experimental Crystal Structure Determination
2013
Related Article: Zachary D. Brown , Petra Vasko , Jeremy D. Erickson , James C. Fettinger , Heikki M. Tuononen , and Philip P. Power|2013|J.Am.Chem.Soc.|135|6257|doi:10.1021/ja4003553
CCDC 736124: Experimental Crystal Structure Determination
2010
Related Article: R.Ballesteros-Garrido, B.Abarca, R.Ballesteros, C.R.de Arellano, F.R.Leroux, F.Colobert, E.Garcia-Espana|2009|New J.Chem.|33|2102|doi:10.1039/b906992e
CCDC 672474: Experimental Crystal Structure Determination
2008
Related Article: Hyui Sul Lee, S.-O.Hauber, D.Vindus, M.Niemeyer|2008|Inorg.Chem.|47|4401|doi:10.1021/ic800029z