Search results for "3-diol"

showing 10 items of 26 documents

Nanocomplexes for gene therapy of respiratory diseases: Targeting and overcoming the mucus barrier

2015

Gene therapy, i.e. the delivery and expression of therapeutic genes, holds great promise for congenital and acquired respiratory diseases. Non-viral vectors are less toxic and immunogenic than viral vectors, although they are characterized by lower efficiency. However, they have to overcome many barriers, including inflammatory and immune mediators and cells. The respiratory and airway epithelial cells, the main target of these vectors, are coated with a layer of mucus, which hampers the effective reaching of gene therapy vectors carrying either plasmid DNA or small interfering RNA. This barrier is thicker in many lung diseases, such as cystic fibrosis. This review summarizes the most impor…

Pulmonary and Respiratory MedicineCystic FibrosisGenetic enhancementContext (language use)Gene deliveryVectors in gene therapyPolyethylene GlycolsViral vectorPolyethyleinimine Poly-L-lysine Ethylene glycol Chitosan PAMAM G0 dendrimer N-(1-(23-Dioleyloxy)propyl)-NNNtrimethylammonium chloride 12-Dioleoylphosphatidylethanolamine N-acetylcystein 12-Dioctadecanoyl-sn-glycero-3-phosphoethanolaminemedicineHumansTechnology PharmaceuticalPharmacology (medical)RNA Small InterferingLungExpectorantsInflammationLungbusiness.industryBiochemistry (medical)Gene Transfer TechniquesGenetic TherapyMucusMucusmedicine.anatomical_structureSettore CHIM/09 - Farmaceutico Tecnologico ApplicativoImmunologyNanoparticlesInflammation MediatorsbusinessPlasmidsRespiratory tract
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CCDC 1959607: Experimental Crystal Structure Determination

2020

Related Article: Jennifer Zablocki, Oriol Arteaga, Frank Balzer, Dirk Hertel, Julian J. Holstein, Guido Clever, Jana Anhäuser, Rakesh Puttreddy, Kari Rissanen, Klaus Meerholz, Arne Lützen, Manuela Schiek|2020|Chirality|32|619|doi:10.1002/chir.23213

Space GroupCrystallographyCrystal SystemCrystal Structure22'-(24-dihydroxycyclobuta-13-diene-13-diyl)bis[5-(2-methylpyrrolidin-1-yl)benzene-13-diol]Cell ParametersExperimental 3D Coordinates
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CCDC 212550: Experimental Crystal Structure Determination

2004

Related Article: M.Dey, C.P.Rao, P.K.Saarenketo, K.Rissanen, E.Kolehmainen, P.Guionneau|2003|Polyhedron|22|3515|doi:10.1016/j.poly.2003.09.015

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parameters2-(N-salicylidene)amino-2-methylpropan-13-diolExperimental 3D Coordinates
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CCDC 903781: Experimental Crystal Structure Determination

2014

Related Article: Mali H. Rosnes, Chiara Musumeci, Carine Yvon, Andrew Macdonell,Chullikkattil P. Pradeep, Camillo Sartorio, De-Liang Long,Bruno Pignataro, Leroy Cronin|2013|Small|9|2316|doi:10.1002/smll.201202510

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parameterstris(Tetraphenylphosphonium) bis(mu7-2-(non-8-en-1-yl)-2-(oxidomethyl)propane-13-diolato)-hexakis(mu2-oxo)-dodeca-oxo-manganese-hexa-molybdenum NN-dimethylformamide solvateExperimental 3D Coordinates
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CCDC 1959439: Experimental Crystal Structure Determination

2020

Related Article: Pasi Salonen, Anssi Peuronen, Ari Lehtonen|2020|Inorg.Chim.Acta|503|119414|doi:10.1016/j.ica.2020.119414

Space GroupCrystallographyCrystal SystemCrystal Structurebis{mu-hydrogen [2-({[35-di-t-butyl-2-oxyphenyl]methylidene}amino)-2-[oxymethyl]propane-13-diolato]}-dioxo-di-vanadium acetonitrile solvateCell ParametersExperimental 3D Coordinates
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CCDC 1959438: Experimental Crystal Structure Determination

2020

Related Article: Pasi Salonen, Anssi Peuronen, Ari Lehtonen|2020|Inorg.Chim.Acta|503|119414|doi:10.1016/j.ica.2020.119414

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parametersaqua-[hydrogen 2-({[35-di-t-butyl-2-oxyphenyl]methylidene}amino)-2-[hydroxymethyl]propane-13-diolato]-dioxo-tungstenExperimental 3D Coordinates
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CCDC 677219: Experimental Crystal Structure Determination

2008

Related Article: K.Ejsmont, J.-P.Joly, E.Wenger, C.Jelsch|2008|Acta Crystallogr.,Sect.C:Cryst.Struct.Commun.|64|o18|doi:10.1107/S0108270107043296

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parameters(2S3S)-2-(NN-Dibenzylamino)butane-13-diolExperimental 3D Coordinates
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CCDC 903785: Experimental Crystal Structure Determination

2014

Related Article: Mali H. Rosnes, Chiara Musumeci, Carine Yvon, Andrew Macdonell,Chullikkattil P. Pradeep, Camillo Sartorio, De-Liang Long,Bruno Pignataro, Leroy Cronin|2013|Small|9|2316|doi:10.1002/smll.201202510

Space GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinatestris(tetra-n-butylammonium) bis(mu-2-(icosanoylamino)-2-(oxidomethyl)propane-13-diolato)-hexakis(mu-oxo)-dodecaoxo-manganese-hexa-molybdenum
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CCDC 1966422: Experimental Crystal Structure Determination

2020

Related Article: Jennifer Zablocki, Oriol Arteaga, Frank Balzer, Dirk Hertel, Julian J. Holstein, Guido Clever, Jana Anhäuser, Rakesh Puttreddy, Kari Rissanen, Klaus Meerholz, Arne Lützen, Manuela Schiek|2020|Chirality|32|619|doi:10.1002/chir.23213

Space GroupCrystallographyCrystal SystemCrystal Structure22'-(24-dihydroxycyclobuta-13-diene-13-diyl)bis[5-(2-methylpyrrolidin-1-yl)benzene-13-diol]Cell ParametersExperimental 3D Coordinates
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CCDC 1959437: Experimental Crystal Structure Determination

2020

Related Article: Pasi Salonen, Anssi Peuronen, Ari Lehtonen|2020|Inorg.Chim.Acta|503|119414|doi:10.1016/j.ica.2020.119414

Space GroupCrystallographycatena-({mu-hydrogen [2-({[35-di-t-butyl-2-oxyphenyl]methylidene}amino)-2-(hydroxymethyl)propane-13-diolato]}-dioxo-di-molybdenum)Crystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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