Search results for "3-diol"

showing 10 items of 26 documents

Nanocomplexes for gene therapy of respiratory diseases: Targeting and overcoming the mucus barrier

2015

Gene therapy, i.e. the delivery and expression of therapeutic genes, holds great promise for congenital and acquired respiratory diseases. Non-viral vectors are less toxic and immunogenic than viral vectors, although they are characterized by lower efficiency. However, they have to overcome many barriers, including inflammatory and immune mediators and cells. The respiratory and airway epithelial cells, the main target of these vectors, are coated with a layer of mucus, which hampers the effective reaching of gene therapy vectors carrying either plasmid DNA or small interfering RNA. This barrier is thicker in many lung diseases, such as cystic fibrosis. This review summarizes the most impor…

Pulmonary and Respiratory MedicineCystic FibrosisGenetic enhancementContext (language use)Gene deliveryVectors in gene therapyPolyethylene GlycolsViral vectorPolyethyleinimine Poly-L-lysine Ethylene glycol Chitosan PAMAM G0 dendrimer N-(1-(23-Dioleyloxy)propyl)-NNNtrimethylammonium chloride 12-Dioleoylphosphatidylethanolamine N-acetylcystein 12-Dioctadecanoyl-sn-glycero-3-phosphoethanolaminemedicineHumansTechnology PharmaceuticalPharmacology (medical)RNA Small InterferingLungExpectorantsInflammationLungbusiness.industryBiochemistry (medical)Gene Transfer TechniquesGenetic TherapyMucusMucusmedicine.anatomical_structureSettore CHIM/09 - Farmaceutico Tecnologico ApplicativoImmunologyNanoparticlesInflammation MediatorsbusinessPlasmidsRespiratory tract
researchProduct

CCDC 886502: Experimental Crystal Structure Determination

2013

Related Article: G.M.Espallargas, A.Recuenco, F.M.Romero, L.Brammer, S.Libri|2012|CrystEngComm|14|6381|doi:10.1039/c2ce26131f

Space GroupCrystallographyCrystal System4455-Tetramethyl-2-phenyl-45-dihydro-1H-3lambda^5^-imidazole-13-diol 22'33'55'66'-octafluoro-44'-diiodobiphenylCrystal StructureCell ParametersExperimental 3D Coordinates
researchProduct

CCDC 1959607: Experimental Crystal Structure Determination

2020

Related Article: Jennifer Zablocki, Oriol Arteaga, Frank Balzer, Dirk Hertel, Julian J. Holstein, Guido Clever, Jana Anhäuser, Rakesh Puttreddy, Kari Rissanen, Klaus Meerholz, Arne Lützen, Manuela Schiek|2020|Chirality|32|619|doi:10.1002/chir.23213

Space GroupCrystallographyCrystal SystemCrystal Structure22'-(24-dihydroxycyclobuta-13-diene-13-diyl)bis[5-(2-methylpyrrolidin-1-yl)benzene-13-diol]Cell ParametersExperimental 3D Coordinates
researchProduct

CCDC 1966422: Experimental Crystal Structure Determination

2020

Related Article: Jennifer Zablocki, Oriol Arteaga, Frank Balzer, Dirk Hertel, Julian J. Holstein, Guido Clever, Jana Anhäuser, Rakesh Puttreddy, Kari Rissanen, Klaus Meerholz, Arne Lützen, Manuela Schiek|2020|Chirality|32|619|doi:10.1002/chir.23213

Space GroupCrystallographyCrystal SystemCrystal Structure22'-(24-dihydroxycyclobuta-13-diene-13-diyl)bis[5-(2-methylpyrrolidin-1-yl)benzene-13-diol]Cell ParametersExperimental 3D Coordinates
researchProduct

CCDC 886501: Experimental Crystal Structure Determination

2013

Related Article: G.M.Espallargas, A.Recuenco, F.M.Romero, L.Brammer, S.Libri|2012|CrystEngComm|14|6381|doi:10.1039/c2ce26131f

Space GroupCrystallographyCrystal SystemCrystal Structure4455-Tetramethyl-2-phenyl-45-dihydro-1H-3lambda^5^-imidazole-13-diol 1245-tetrafluoro-36-diiodobenzeneCell ParametersExperimental 3D Coordinates
researchProduct

CCDC 2081480: Experimental Crystal Structure Determination

2022

Related Article: Leander Geske, Ulrich Kauhl, Mohamed Saeed, Anja Schüffler, Eckhard Thines, Thomas Efferth, Till Opatz|2021|Molecules|26|3224|doi:10.3390/molecules26113224

Space GroupCrystallographyCrystal SystemCrystal Structure5-[2-(3-hydroxyphenyl)ethyl]-4-[(4-hydroxyphenyl)methyl]benzene-13-diolCell ParametersExperimental 3D Coordinates
researchProduct

CCDC 172273: Experimental Crystal Structure Determination

2002

Related Article: B.Osmialowski, E.Kolehmainen, M.Nissinen, T.M.Krygowski, R.Gawinecki|2002|J.Org.Chem.|67|3339|doi:10.1021/jo016293b

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parameters(1Z3Z)-14-bis(Pyridin-2-yl)buta-13-diene-23-diolExperimental 3D Coordinates
researchProduct

CCDC 677219: Experimental Crystal Structure Determination

2008

Related Article: K.Ejsmont, J.-P.Joly, E.Wenger, C.Jelsch|2008|Acta Crystallogr.,Sect.C:Cryst.Struct.Commun.|64|o18|doi:10.1107/S0108270107043296

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parameters(2S3S)-2-(NN-Dibenzylamino)butane-13-diolExperimental 3D Coordinates
researchProduct

CCDC 1862545: Experimental Crystal Structure Determination

2019

Related Article: Kubandiran Kolanji, Lars Postulka, Bernd Wolf, Michael Lang, Dieter Schollmeyer, and Martin Baumgarten|2019|J.Org.Chem.|84|140|doi:10.1021/acs.joc.8b02499

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parameters22'-[(48-dimethoxybenzo[12-b:45-b']bisthiene-26-diyl)bis(thiene-52-diyl)]bis(4455-tetramethyl-45-dihydro-1H-3lambda5-imidazole-13-diolate) diradicalExperimental 3D Coordinates
researchProduct

CCDC 212550: Experimental Crystal Structure Determination

2004

Related Article: M.Dey, C.P.Rao, P.K.Saarenketo, K.Rissanen, E.Kolehmainen, P.Guionneau|2003|Polyhedron|22|3515|doi:10.1016/j.poly.2003.09.015

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parameters2-(N-salicylidene)amino-2-methylpropan-13-diolExperimental 3D Coordinates
researchProduct