Search results for "301"
showing 10 items of 14241 documents
‘The best guess for the future?’ Teachers’ adaptation to open and flexible learning environments in Finland
2021
Finnish education has recently experienced reforms with respect to guidelines forming the curriculum framework for basic education and school architecture. Since 2016, all new schools incorporate open and flexible design, at least to some extent. The more open school design challenges the conventional organisation of space and pre-defined structures and interaction practices. This study investigates how teachers both adapt and are affected by new demands for pedagogy, team teaching and teacher-student relationships. Interview data of 21 teachers of six modern schools are reviewed through thematic analysis. The new school layouts provided some incongruence with the teachers’ aims and their p…
Intra‐individual dynamics of lesson‐specific engagement: Lagged and cross‐lagged effects from one lesson to the next
2020
Background Student engagement denotes active participation in academic work through commitment and involvement in learning tasks (Appleton et al., 2006, Journal of School Psychology, 44, 427). This study looks at questions such as whether engagement experiences in one lesson have an effect on the next lesson. In the present study, process‐oriented analyses were conducted to examine lower secondary school students’ engagement experiences and the stability of those experiences from one lesson to the next. Aims (1) To what extent are students’ engagement experiences, in terms of behavioural and cognitive engagement, emotional engagement, and disaffection, stable from one lesson to the next (au…
Chikage Oba-Smidt, The Oral Chronicle of the Boorana in Southern Ethiopia: Modes of Construction and Preservation of History among People without Wri…
2017
Review
Mathematical and Coding Lessons Based on Creative Origami Activities
2019
AbstractThis paper considers how creativity and creative activities can be encouraged in regular mathematical classes by combining different teaching approaches and academic disciplines. We combined origami and paper folding with fractals and their mathematical properties as well as with coding in Scratch in order to facilitate learning mathematics and computer science. We conducted a case study experiment in a Serbian school with 15 high school students and applied different strategies for learning profound mathematical and coding concepts such as fractals dimension and recursion. The goal of the study was to employ creative activities and examine students’ activities during this process i…
Ideas for using GeoGebra and Origami in Teaching Regular Polyhedrons Lessons
2018
The approach of combining GeoGebra and origami is well accepted among students in the school "Petro Kuzmjak" where it is used to teach geometry lessons. This article elaborates on how to introduce students (upper elementary and high school students, age 14-18) to Platonic solids and their properties through combination of GeoGebra and origami activities. Some of the important mathematical concepts related to these well-known geometrical solids can be explained to students applying hands-on activities along with educational software. peerReviewed
Misfit evaluation of dental implant-supported metal frameworks manufactured with different techniques: Photoelastic and strain gauge measurements
2016
This study aims to compare in-vitro the fitting accuracy of implant-supported metal frameworks used for full-arch orthodontic restoration. The hypotheses tested were as follows: (1) for a fixed implant morphology, strains developed within the framework depend on how the framework had been fabricated and (2) stresses transferred to the implant–bone interface are related to the amount of framework misfit. Metal frameworks were fabricated using four different manufacturing techniques: conventional lost-wax casting, resin cement luting, electrospark erosion, and computer-aided design/computer-aided manufacturing milling. Each framework was instrumented with three strain gauges to measure strai…
A novel intrinsically disordered outer membrane lipoprotein ofAggregatibacter actinomycetemcomitansbinds various cytokines and plays a role in biofil…
2017
Intrinsically disordered proteins (IDPs) do not have a well-defined and stable 3-dimensional fold. Some IDPs can function as either transient or permanent binders of other proteins and may interact with an array of ligands by adopting different conformations. A novel outer membrane lipoprotein, bacterial interleukin receptor I (BilRI) of the opportunistic oral pathogen Aggregatibacter actinomycetemcomitans binds a key gatekeeper proinflammatory cytokine interleukin (IL)-1b. Because the amino acid sequence of the novel lipoprotein resembles that of fibrinogen binder A of Haemophilus ducreyi, BilRI could have the potential to bind other proteins, such as host matrix proteins. However, from th…
Molluscan antimicrobial peptides, a review from activity-based evidences to computer-assisted sequences
2011
Antimicrobial peptides (AMPs) represent the most universal immune effectors. Molluscs constitute the second largest animal phylum, after Arthropods, in term of number of species. Only a negligible number has been investigated regarding AMPs. The choice of the species to be studied relied on their economical importance and availability. First studies on molluscan AMPs dated from 1996 and were based on biological activities of biochemical-purified fractions. Such approach released all the original structures we know, with biological activity sometimes different from one isoform to another. Then, molecular biology techniques were applied to molluscan AMPs starting in 1999. Complete screening o…
Epigenetic siRNA and Chemical Screens Identify SETD8 Inhibition as a Therapeutic Strategy for p53 Activation in High-Risk Neuroblastoma
2017
Given the paucity of druggable mutations in high-risk neuroblastoma (NB), we undertook chromatin-focused small interfering RNA and chemical screens to uncover epigenetic regulators critical for the differentiation block in high-risk NB. High-content Opera imaging identified 53 genes whose loss of expression led to a decrease in NB cell proliferation and 16 also induced differentiation. From these, the secondary chemical screen identified SETD8, the H4K20me1 methyltransferase, as a druggable NB target. Functional studies revealed that SETD8 ablation rescued the pro-apoptotic and cell-cycle arrest functions of p53 by decreasing p53K382me1, leading to activation of the p53 canonical pathway. I…
Genetic profile and immunohistochemical study of clear cell renal carcinoma: Pathological-anatomical correlation and prognosis.
2021
Abstract Introduction Renal cell carcinoma (RCC) accounts for 2–3% of all tumors being the most frequent solid lesion in the kidney. Objective To determine what genetic alterations and immunohistochemical (IHC) of clear cell renal carcinoma (ccRCC) are associated with prognosis and tumor aggressiveness. Patients and Methods Experimental analytical study with 57 patients who underwent radical and partial nephrectomy between 2005 and 2011, all with diagnosis of ccRCC and minimum post-operative follow-up of 36 months. The pathological study included IHC determination of biomarkers associated (CAIX, CAM 5.2, CD10, c-erbB-2, EGFR, HIF-1a, Ki67, MDM2, PAX-2 y 8, p53, survivin and VEGFR 1 and 2). …