Search results for "301"
showing 10 items of 14241 documents
MTOR inhibitor-based combination therapies for pancreatic cancer
2018
Background: Although the mechanistic target of rapamycin (MTOR) kinase, included in the mTORC1 and mTORC2 signalling hubs, has been demonstrated to be active in a significant fraction of patients with pancreatic ductal adenocarcinoma (PDAC), the value of the kinase as a therapeutic target needs further clarification. Methods: We used Mtor floxed mice to analyse the function of the kinase in context of the pancreas at the genetic level. Using a dual-recombinase system, which is based on the flippase-FRT (Flp-FRT) and Cre-loxP recombination technologies, we generated a novel cellular model, allowing the genetic analysis of MTOR functions in tumour maintenance. Cross-species validation and pha…
Heat Shock Protein 60 in Hepatocellular Carcinoma: Insights and Perspectives
2020
Heat shock protein 60 (HSP60) is a mitochondrial chaperone that is implicated in physiological and pathological processes. For instance, it contributes to protein folding and stability, translocation of mitochondrial proteins, and apoptosis. Variations in the expression levels of HSP60 have been correlated to various diseases and cancers, including hepatocellular carcinoma (HCC). Unlike other HSPs which clearly increase in some cancers, data about HSP60 levels in HCC are controversial and difficult to interpret. In the current review, we summarize and simplify the current knowledge about the role of HSP60 in HCC. In addition, we highlight the possibility of its targeting, using chemical com…
Protein tyrosine nitration and thiol oxidation by peroxynitrite-strategies to prevent these oxidative modifications.
2013
The reaction product of nitric oxide and superoxide, peroxynitrite, is a potent biological oxidant. The most important oxidative protein modifications described for peroxynitrite are cysteine-thiol oxidation and tyrosine nitration. We have previously demonstrated that intrinsic heme-thiolate (P450)-dependent enzymatic catalysis increases the nitration of tyrosine 430 in prostacyclin synthase and results in loss of activity which contributes to endothelial dysfunction. We here report the sensitive peroxynitrite-dependent nitration of an over-expressed and partially purified human prostacyclin synthase (3.3 μM) with an EC50 value of 5 μM. Microsomal thiols in these preparations effectively co…
Digital competence in the curricula of Spanish public universities
2018
[EN] The massive incorporation of the technological resources in the classrooms of the infantile and primary centers has been a reality evident for some years, thanks to state plans like School 2.0 or autonomous ones like EducaMadrid or the Intelligent Educational Centers in the Valencian Community. And although much has been written in recent times about digital competence and the initial training of teachers in public universities, it is necessary to continue investigating and reflecting on their suitability and implementation in a society in continuous technological change. On this subject, in these lines it is tried to analyze the curriculum of the Teaching Degrees of several public uni…
A Study on the Assessment of Introductory Computational Thinking via Scratch Programming in Primary Schools
2018
Computational thinking (CT), a transversal intellectual foundation integral to computer science, is making its way into compulsory comprehensive education worldwide. Students are expected to attain skills and knowledge in such interdisciplinary CT principles as Algorithmic thinking, Data representation, and Debugging. Problem-solving by designing and manipulating interactive media with Scratch, a graphical programming tool, is popular especially at the primary school level. However, there has been confusion regarding how introductory CT can be operationalized for educational practice. Teachers and students need research-based knowledge for setting appropriate learning goals in addition to i…
Neurocognitive Predictors of Response to Intervention With GraphoGame Rime
2021
This study explores the neurocognitive predictors of response to intervention with GraphoGame Rime, an adaptive software game designed to aid the learning of English phonics. A cohort of 398 children (aged 6 – 7 years) who had participated in a recent Randomized Controlled Trial (RCT) of GraphoGame Rime in the United Kingdom were studied. Half were randomly assigned to play GraphoGame Rime (GG Rime) and the other half were assigned to Business As Usual (BAU). A series of pretests were given prior to the intervention to all participants, designed to measure phonological awareness skills, executive function (EF) skills and the ability to synchronise finger tapping to a rhythmic beat. Finger t…
Self-regulatory efficacy and sources of efficacy in elementary school pupils: Self-regulatory experiences in a population sample and pupils with atte…
2019
In this study, we examined self-regulatory efficacy and sources of self-efficacy (mastery experiences, vicarious experiences, social persuasion and physiological/emotional states) and the relationships between self-efficacy and its sources among elementary school pupils. Two groups were compared: a population sample (PS, N = 1284) and pupils with difficulties in attention and executive functions (AED, N = 61). Data gathered from self-report questionnaires indicated that pupils in the PS group had more positive efficacy beliefs and mastery experiences and fewer negative physiological/emotional states than the AED group. Analyses showed strong connections between sources and self-regulatory e…
Response-To-Intervention in Finland and the United States: Mathematics Learning Support as an Example
2018
Response to Intervention (RTI) was accepted in the early 2000s as a new framework for identifying learning difficulties (LD) in the U.S. In Finland, a similar multi-tiered framework has existed since 2010. In the present study, these frameworks are presented from the viewpoint of the role of assessment and instruction as expressed in documents that describe the frameworks, as it seems that these two components of RTI are the most disparate between the U.S. and Finland. We present a suggestion for the Finnish framework as an example of support in mathematics learning that incorporates principles of RTI (such as systematized assessment and instruction, cyclic support, and modifiable instructi…
The Art-Based Methods in Developing Transversal Competence
2019
This article describes a project called “The art based methods in developing transversal competence” funded by The Finnish National Board of Education. The article is based on the hermeneutic phenomenological approach in action research. The project developed learning environments as well as project-based learning with emphasis on the art-based methods and transversal competence approach to learning. The aim was to develop unique and communal well-being in learning. The project offered tools to strengthen teachers’ professional skills to use expressive, art-based methods in different curriculum-based projects. The professional in-service training project included five contact days in six we…
Student teachers and their identity construction and awareness of multilingualism: re-visiting three studies
2019
[EN] This article re-visits three studies that originally focused on beliefs about second language (L2) learning and teaching held by student teachers. The studies have been conducted in the same educational context (that is, at a Finnish university). The participants in the studies are majors or minors in English, Swedish, German, etc., and they range from first-year students to fifth-year students about to graduate as qualified L2 teachers. Data have been collected by a variety of means over the past few years (questionnaires, sentence-completion tasks, drawings), and partly longitudinally. The pools of data (verbal and visual) will be re-analysed from the perspective of identity construc…