Search results for "302"
showing 10 items of 27399 documents
Dexamethasone premedication suppresses vaccine-induced immune responses against cancer
2020
ABSTRACT Glucocorticosteroids (GCS) have an established role in oncology and are administered to cancer patients in routine clinical care and in drug development trials as co-medication. Given their strong immune-suppressive activity, GCS may interfere with immune-oncology drugs. We are developing a therapeutic cancer vaccine, which is based on a liposomal formulation of tumor-antigen encoding RNA (RNA-LPX) and induces a strong T-cell response both in mice as well as in humans. In this study, we investigated in vivo in mice and in human PBMCs the effect of the commonly used long-acting GCS Dexamethasone (Dexa) on the efficacy of this vaccine format, with a particular focus on antigen-specif…
Transcranial Alternating Current Stimulation (tACS) Does Not Affect Sports People’s Explosive Power: A Pilot Study
2021
Purpose: This study is aimed to preliminary investigate whether transcranial alternating current stimulation (tACS) could affect explosive power considering genetic background in sport subjects.Methods: Seventeen healthy sports volunteers with at least 3 years of sports activities participated in the experiment. After 2 weeks of familiarization performed without any stimulation, each participant received either 50 Hz-tACS or sham-tACS. Before and after stimulation, subjects performed the following tests: (1) the squat jump with the hands on the hips (SJ); (2) countermovement jump with the hands on the hips (CMJ); (3) countermovement jump with arm swing (CMJ-AS); (4) 15-s Bosco’s test; (5) s…
How many longitudinal covariate measurements are needed for risk prediction?
2014
Abstract Objective In epidemiologic follow-up studies, many key covariates, such as smoking, use of medication, blood pressure, and cholesterol, are time varying. Because of practical and financial limitations, time-varying covariates cannot be measured continuously, but only at certain prespecified time points. We study how the number of these longitudinal measurements can be chosen cost-efficiently by evaluating the usefulness of the measurements for risk prediction. Study Design and Setting The usefulness is addressed by measuring the improvement in model discrimination between models using different amounts of longitudinal information. We use simulated follow-up data and the data from t…
Exploiting ongoing EEG with multilinear partial least squares during free-listening to music
2016
During real-world experiences, determining the stimulus-relevant brain activity is excitingly attractive and is very challenging, particularly in electroencephalography. Here, spectrograms of ongoing electroencephalogram (EEG) of one participant constructed a third-order tensor with three factors of time, frequency and space; and the stimulus data consisting of acoustical features derived from the naturalistic and continuous music formulated a matrix with two factors of time and the number of features. Thus, the multilinear partial least squares (PLS) conforming to the canonical polyadic (CP) model was performed on the tensor and the matrix for decomposing the ongoing EEG. Consequently, we …
Career Transitions of eSports Athletes : A Proposal for a Research Framework
2017
eSports has boomed, the number of eSport athletes has grown rapidly, and many teenagers aspire to a have career in eSports. However, eSports athletes' careers involve many problems, such as career-entry difficulties, straining life habits, burnout, premature retirement, and post-career dilemmas. Despite a growing research interest in eSports, a void of knowledge exists regarding eSports athletes' career aspects. To address the gap in research, this paper aims to take an initial step by proposing a framework for eSports athletes' career transitions. The framework combines two approaches from sport psychology and sport literature. The framework can help eSports athletes, coaches, and other st…
Operator Revenue Analysis for Device-to-Device Communications Overlaying Cellular Network
2018
Device-to-device (D2D) communications has recently gathered significant research interest due to its efficient utilization of already depleting wireless spectrum. In this article, we considered a scenario where D2D users communicate in the presence of cellular users in an overlay network setup. In order to analyze the revenue of service providers in monetary terms, the paper provides exact expressions of operator profit for both D2D and cellular users. More specifically, we take into account different network parameters including user density, transmit power and channel variations to understand their impact on the total revenue of the operator. Finally, we derive the balancing value of freq…
Higher-order Nonnegative CANDECOMP/PARAFAC Tensor Decomposition Using Proximal Algorithm
2019
Tensor decomposition is a powerful tool for analyzing multiway data. Nowadays, with the fast development of multisensor technology, more and more data appear in higherorder (order > 4) and nonnegative form. However, the decomposition of higher-order nonnegative tensor suffers from poor convergence and low speed. In this study, we propose a new nonnegative CANDECOM/PARAFAC (NCP) model using proximal algorithm. The block principal pivoting method in alternating nonnegative least squares (ANLS) framework is employed to minimize the objective function. Our method can guarantee the convergence and accelerate the computation. The results of experiments on both synthetic and real data demonstrate …
Curvelet-based method for orientation estimation of particles
2013
A method based on the curvelet transform is introduced for estimating from two-dimensional images the orientation distribution of small anisotropic particles. Orientation of fibers in paper is considered as a particular application of the method. Theoretical aspects of the suitability of this method are discussed and its efficiency is demonstrated with simulated and real images of fibrous systems. Comparison is made with two traditionally used methods of orientation analysis, and the new curvelet-based method is shown to perform clearly better than these traditional methods.
Social support in the workplace for physicians in specialization training
2018
ABSTRACT When becoming a specialist, learning-through-service plays a significant role. The workplace affords good opportunities for learning, but the service-learning period may also impose stress on phycisians in specialization training. In medical work, social support has proved to be a very important factor in managing stress. Social support may afford advantages also for learning and professional identity building. However, little was known about how social support is perceived by doctors in specialization training. This study aimed to understand the perceptions of physicians in specialization training regarding social support communication in their workplace during their learning-thro…
Cultural Politics of Love and Provision among Poor Youth in Urban Tanzania
2015
This article examines how urban youth in the poorest neighbourhoods of Dar es Salaam negotiate the terms of transactional intimacy, that is, heterosexual relations in which men are expected to provide for women materially. Using the concept of ‘affect’, I argue that this negotiation involves different levels of male providership, as well as moral values attached to notions of ‘true love’ and the Swahili concept of tamaa. Poor men and women view their agency differently within transactional intimacy, with women describing themselves as exploited by men who do not fulfil their end of the transactional bargain, and poor men portraying themselves as deeply disempowered in comparison to wealthie…