Search results for "302"

Drivers’ experiences during floods: Investigating the psychological influences underpinning decisions to avoid driving through floodwater

2018

Abstract A major risk factor for many flood-related drownings is driving through floodwater. We aimed to understand Australian drivers’ experiences and beliefs with respect to avoid driving through floodwater using the theory of planned behaviour as a framework. Study 1 (N = 23) used a qualitative design to gain an in-depth understanding of individuals’ experiences with driving through floodwater. Study 2 (N = 157) used a survey-based design to identify the factors related to this behaviour including knowledge, beliefs, and social-cognitive factors. In Study 1, drivers identified a range of advantages (e.g., didn’t damage car), disadvantages (e.g., inconvenient, but not so terrible), barrie…

On the Choice of the Extracellular Vesicles for Therapeutic Purposes

2019

Extracellular vesicles (EVs) are lipid membrane vesicles released by all human cells and are widely recognized to be involved in many cellular processes, both in physiological and pathological conditions. They are mediators of cell-cell communication, at both paracrine and systemic levels, and therefore they are active players in cell differentiation, tissue homeostasis, and organ remodeling. Due to their ability to serve as a cargo for proteins, lipids, and nucleic acids, which often reflects the cellular source, they should be considered the future of the natural nanodelivery of bio-compounds. To date, natural nanovesicles, such as exosomes, have been shown to represent a source of diseas…

Relationship Between Cannabis Use and Erectile Dysfunction: A Systematic Review and Meta-Analysis

2019

Globally, there is increasing usage and legalization of cannabis. In addition to its reported therapeutic effects, cannabis has several health risks which are not clearly defined. Erectile dysfunction (ED) is the most common male sexual disorder and there are plausible mechanisms linking cannabis use to ED. No attempt has been made to collate the literature on this topic. The aim of this review was to summarize the prevalence and risk of ED in cannabis users compared to controls. A systematic review of major databases from inception to January 1, 2019, without language restriction, was undertaken to identify studies investigating cannabis use and presence of ED. The analysis compared the p…

Self-reported reflective functioning mediates the association between attachment insecurity and well-being among psychotherapists.

2020

Objective: Subjective well-being is a crucial variable for mental health practitioners. This study examines the influence of therapists’ attachment dimensions and self-reported reflective functioning on their perceived well-being. Further, it examines if reflective functioning mediates the association between attachment insecurity and well-being. Method: A total of 416 experienced psychotherapists were enrolled in this cross-sectional study, and completed self-report measures of attachment insecurity, reflective functioning, and well-being. We tested the hypothesized mediation model with path analysis that examined indirect effects. Results: Both attachment anxiety and avoidance dimensions …

Protein tyrosine nitration and thiol oxidation by peroxynitrite-strategies to prevent these oxidative modifications.

2013

The reaction product of nitric oxide and superoxide, peroxynitrite, is a potent biological oxidant. The most important oxidative protein modifications described for peroxynitrite are cysteine-thiol oxidation and tyrosine nitration. We have previously demonstrated that intrinsic heme-thiolate (P450)-dependent enzymatic catalysis increases the nitration of tyrosine 430 in prostacyclin synthase and results in loss of activity which contributes to endothelial dysfunction. We here report the sensitive peroxynitrite-dependent nitration of an over-expressed and partially purified human prostacyclin synthase (3.3 μM) with an EC50 value of 5 μM. Microsomal thiols in these preparations effectively co…

Thrombolysis Followed by Apixaban for Massive Pulmonary Embolism and Free-floating Thrombus in Right Ventricle in a Patient with Breast Cancer

2018

Free-floating thrombus in the right ventricle, associated with a massive acute pulmonary embolism (PE), is a rare phenomenon. PE is an important clinical entity with considerable mortality despite advances in diagnosis and treatment. The prognosis of PE depends on right ventricular dysfunction, myocardial injury markers, and early treatment. In this report, we present the case of a 71-year-old woman with a history of breast cancer admitted to intensive care unit for PE complicated by syncope. Although our case may seem complex because it is not represented in the guidelines, the result was satisfactory and showed how treatment with new anticoagulants (in this case apixaban) after massive th…

Editorial: Thymic Epithelial Cells: New Insights Into the Essential Driving Force of T-Cell Differentiation.

2021

Overview of Power Electronic Switches: A Summary of the Past, State-of-the-Art and Illumination of the Future.

2020

As the need for green and effective utilization of energy continues to grow, the advancements in the energy and power electronics industry are constantly driven by this need, as both industries are intertwined for obvious reasons. The developments in the power electronics industry has over the years hinged on the progress of the semiconductor device industry. The semiconductor device industry could be said to be on the edge of a turn into a new era, a paradigm shift from the conventional silicon devices to the wide band gap semiconductor technologies. While a lot of work is being done in research and manufacturing sectors, it is important to look back at the past, evaluate the current progr…

External Assessors as “Reviewers” for Quality Assurance of Open Access Journals

2017

Radical Besinnung in Formale und transzendentale Logik (1929)

2018

This paper explicates Husserl’s usage of what he calls “radical Besinnung” in Formale und transzendentale Logik (1929). Husserl introduces radical Besinnung as his method in the introduction to FTL. Radical Besinnung aims at criticizing the practice of formal sciences by means of transcendental phenomenological clarification of its aims and presuppositions. By showing how Husserl applies this method to the history of formal sciences down to mathematicians’ work in his time, the paper explains in detail the relationship between historical critical Besinnung and transcendental phenomenology. Ultimately the paper suggests that radical Besinnung should be viewed as a general methodological fram…