Search results for "310"

Sánchez-Montes González, Francisco, Jiménez Estrella, Antonio, Lozano Navarro, Julián J. (editores). El Reino de Granada y la Monarquía Hispánica en …

2021

Observation of an Excited $B^{\pm}_c$ Meson State with the ATLAS Detector

2014

A search for excited states of the B±c meson is performed using 4.9 fb-1 of 7 TeV and 19.2 fb-1 of 8 TeV pp collision data collected by the ATLAS experiment at the LHC. A new state is observed through its hadronic transition to the ground state, with the latter detected in the decay B±c→J/ψπ±. The state appears in the m(Bc±π+π-)-m(Bc±)-2m(π±) mass difference distribution with a significance of 5.2 standard deviations. The mass of the observed state is 6842±4±5 MeV, where the first error is statistical and the second is systematic. The mass and decay of this state are consistent with expectations for the second S-wave state of the B±c meson, B±c(2S).

“Questa donna dal viso netto e gioioso”: Simone de Beauvoir e la stampa italiana

2018

Proseguiamo la riscoperta di Simone de Beauvoir iniziata nel numero precedente: questa volta ripresentiamo due sue interviste dimenticate uscite nel 1959 e nel 1961 sul “Giorno” e su “Paese Sera”. 

Extraction of lipids from microalgae using classical and innovative approaches

2022

Microalgae, as a photosynthetic autotrophic organism, contain a variety of bioactive compounds, including lipids, proteins, polysaccharides, which have been applied in food, medicine, and fuel industries, among others. Microalgae are considered a good source of marine lipids due to their high content in unsaturated fatty acid (UFA) and can be used as a supplement/replacement for fish-based oil. The high concentration of docosahexaenoic (DHA) and eicosapentaenoic acids (EPA) in microalgae lipids, results in important physiological functions, such as antibacterial, anti-inflammatory, and immune regulation, being also a prerequisite for its development and application. In this paper, a variety…

Black hole lightning due to particle acceleration at subhorizon scales

2015

Supermassive black holes with masses of millions to billions of solar masses are commonly found in the centers of galaxies. Astronomers seek to image jet formation using radio interferometry, but still suffer from insufficient angular resolution. An alternative method to resolve small structures is to measure the time variability of their emission. Here, we report on gamma-ray observations of the radio galaxy IC 310 obtained with the MAGIC telescopes revealing variability with doubling time scales faster than 4.8 min. Causality constrains the size of the emission region to be smaller than 20\% of the gravitational radius of its central black hole. We suggest that the emission is associated …

Small, dense low-density lipoproteins (LDL) are predictors of cardio- and cerebro-vascular events in subjects with the metabolic syndrome

2009

Summary Objective  Small, dense low-density lipoproteins (LDL) are a feature of the metabolic syndrome (MS) but their predictive role still remains to be established. We performed a 2-year follow-up study in 124 subjects with MS (63 ± 6 years), as defined by the American Heart Association/National Heart, Lung and Blood Institute guidelines, to assess clinical and biochemical predictors of cerebro- and cardio-vascular events. Methods and results  Beyond traditional cardiovascular risk factors, we measured LDL size and subclasses by gradient gel electrophoresis. Clinical events were registered in the 25% of subjects. At univariate analysis subjects with events had increased prevalence of elev…

Synthesis and studies of new optimised chelating agents for targeting chemokine receptor CXCR4

2012

The objective of this thesis work was to develop CXCR4-targeted tools to localize and treat cancer at an early stage. In this line, we investigated the synthesis of new target-specific radiopharmaceuticals. The work focused on two main axes, i.e. the chelating agent and the carrier, by using the know-how and the expertise of our group in polyazacycloalkanes synthesis and functionalization. In the first part, we were interested in developing new macrocyclic scaffolds of high potential for copper and gallium chelation. We first focused on the development of a new powerful route towards selectively functionalized constrained homocyclens. The second part was based on C-functionalized 1,4,7-tria…

HGG-03. THE GLYCOSPHINGOLIPIDS METABOLISM IS A NOVEL TARGET IN H3K27M-MUTANT DIFFUSE MIDLINE GLIOMA

2021

Abstract H3K27M-mutant diffuse midline glioma (H3K27M-mutant DMG) is a rare malignant brain tumour entity in children and adults with a median overall survival of around 12 months. Genomic and proteomic analysis may help to identify new target structures, however not all relevant targets are covered by these analyses. Glycosphingolipids and particularly gangliosides play a major role in brain development and have been involved in the pathology of brain tumours. The conversion of ceramide to glucosylceramide via glucosylceramide synthase (GCS) is one of the first steps in the synthesis of glycosphingolipids. Therefore, targeting GCS will inhibit their synthesis. Here we analysed the glycosph…

EPCT-15. RAPID EPIGENOMIC CLASSIFICATION OF BRAIN TUMORS ENABLES INTRAOPERATIVE NEUROSURGICAL RISK MODULATION

2021

Abstract Background Clear identification of tumor subtype is the main predictor of patient outcome and ultimately what is considered an adequate level of surgical risk. At brain tumor resection, imaging modalities and intraoperative histology often give an ambigious diagnosis, complicating intraoperative surgical decision-making. Here, we report a nanopore DNA methylation analysis (NDMA) sequencing approach combined with machine learning for classification of tumor entities that could be used intraoperatively. Methods We analyzed 50 biopsies obtained from biobanked tissue (43, prospective) or sampled at surgery (7, intraoperative) from 20 female and 30 male patients with a median age of 8 y…

The Translation Scene in Latvia (Latvian SSR) during the Stalinist Years

2018

[full article, abstract in English; abstract in Lithuanian] In this paper the author continues to explore the translation scene in 20th century Latvia (Veisbergs 2016a). The period under discussion covers 1945–1953, the years of Stalin’s rule after WWII until his death in 1953. The translation situation is described by discussing nationalisation and centralisation of publishers, book liquidation, censorship, ideologisation and politicisation, russification, Latvian émigré translations and other aspects of importance in an attempt to present the translation scene of the period from different angles. At the end of the article an extensive list of references is provided that can serve as an in…