Search results for "311"
showing 10 items of 433 documents
Polymorphisms in the Serotonin (5-Hydroxytryptamine (5-HT)) Type 2A Receptor (5-HTR2A) Gene, Other Related Genes and Anthropometry
2012
Serotonin or 5-hydroxytryptamine (5-HT) is a monoamine neurotransmitter, which helps to regulate many physiological processes such as sleep, appetite, eating disorders, thermoregulation, hormone secretion, mood, anxiety, etc. The serotonin and related genes, such as the 5-HT2A receptor gene (HTR2A), the 5-HT transporter gene (SLC6A4), the 5-HT2C receptor gene (HTR2C), or the 5-HT1A receptor (HTR1A) gene, are re-emerging as powerful candidates for studying the association between food intake and anthropometry. Variations in all of these genes need to be studied to better understand the effects of serotonin and its receptors on anthropometry. The most widely studied polymorphism is the −1438G…
Molecular and Translational Classifications of DAMPs in Immunogenic Cell Death
2015
The immunogenicity of malignant cells has recently been acknowledged as a critical determinant of efficacy in cancer therapy. Thus, besides developing direct immunostimulatory regimens, including dendritic cell-based vaccines, checkpoint-blocking therapies, and adoptive T-cell transfer, researchers have started to focus on the overall immunobiology of neoplastic cells. It is now clear that cancer cells can succumb to some anticancer therapies by undergoing a peculiar form of cell death that is characterized by an increased immunogenic potential, owing to the emission of the so-called "damage-associated molecular patterns" (DAMPs). The emission of DAMPs and other immunostimulatory factors by…
Case-specific performance of MM-PBSA, MM-GBSA, and SIE in virtual screening.
2015
In drug discovery the reliable prediction of binding free energies is of crucial importance. Methods that combine molecular mechanics force fields with continuum solvent models have become popular because of their high accuracy and relatively good computational efficiency. In this research we studied the performance of molecular mechanics generalized Born surface area (MM-GBSA), molecular mechanics Poisson-Boltzmann surface area (MM-PBSA), and solvated interaction energy (SIE) both in their virtual screening efficiency and their ability to predict experimentally determined binding affinities for five different protein targets. The protein-ligand complexes were derived with two different app…
The relationship between electrophysiological and hemodynamic measures of neural activity varies across picture naming tasks: A multimodal magnetoenc…
2022
Funding Information: This work was financially supported by the Academy of Finland (Finnish Center of Excellence in Computational Inference Research COIN and grants #292334, #294238 to SK; #255349, #315553 to RS; #257576 to JK; #286405 funding for TM), the Sigrid Jusélius Foundation (grant to RS), the Finnish Cultural Foundation (grant to ML), the Swedish Cultural Foundation in Finland (grant to ML), the Maud Kuistila Memorial Foundation (grant to ML), and Aalto Brain Center. Publisher Copyright: Copyright © 2022 Mononen, Kujala, Liljeström, Leppäaho, Kaski and Salmelin. Different neuroimaging methods can yield different views of task-dependent neural engagement. Studies examining the relat…
Constant Power Model in Arm Rotation—A New Approach to Hill’s Equation
2014
The purpose of this study was to further develop the constant power model of a previous study and to provide the final solution of Hill’s force-velocity equation. Forearm and whole arm rotations of three different subjects were performed downwards (elbow and shoulder extension) and upwards (elbow and shoulder flexion) with maximum velocity. These arm rotations were recorded with a special camera system and the theoretically derived model of constant maximum power was fitted to the experimentally measured data. The moment of inertia of the arm sectors was calculated using immersion technique for determining accurate values of friction coefficients of elbow and whole arm rotations. The experi…
Myostatin/activin blocking combined with exercise reconditions skeletal muscle expression profile of mdx mice
2015
Duchenne Muscular Dystrophy is characterized by muscle wasting and decreased aerobic metabolism. Exercise and blocking of myostatin/activin signaling may independently or combined counteract muscle wasting and dystrophies. The effects of myostatin/activin blocking using soluble activin receptor-Fc (sActRIIB-Fc) administration and wheel running were tested alone or in combination for seven weeks in dystrophic mdx mice. Expression microarray analysis revealed decreased aerobic metabolism in the gastrocnemius muscle of mdx mice compared to healthy mice. This was not due to reduced home-cage physical activity, and was further downregulated upon sActRIIB-Fc treatment in enlarged muscles. However…
Micromechanical Properties and Collagen Composition of Ruptured Human Achilles Tendon
2012
Background:The Achilles tendon is one of the strongest tendons in the human body, and yet it frequently ruptures, which is a substantial clinical problem. However, the cause of ruptures remains elusive.Hypothesis:Ruptured human Achilles tendon displays inferior biomechanical properties and altered collagen composition compared with noninjured tendon.Study Design:Controlled laboratory study.Methods:Biopsy specimens were obtained at the rupture site and the noninjured part of the tendon (internal controls) in 17 patients with acute Achilles tendon rupture. Age- and weight-matched human cadaveric Achilles tendons (external controls) were also obtained. Tendon samples were tested micromechanica…
Processing of an Audiobook in the Human Brain Is Shaped by Cultural Family Background
2022
Funding Information: Funding: This work was supported by the Academy of Finland [257811, 273469, 276643, 287474, 332309]; Jane and Aatos Erkko Foundation; Emil Aaltonen Foundation; Paulo Foundation and Russian Science Foundation grant [No: 22-48-08002]. Publisher Copyright: © 2022 by the authors. Licensee MDPI, Basel, Switzerland. Perception of the same narrative can vary between individuals depending on a listener’s previous experiences. We studied whether and how cultural family background may shape the processing of an audiobook in the human brain. During functional magnetic resonance imaging (fMRI), 48 healthy volunteers from two different cultural family backgrounds listened to an audi…
Association between spinal disorders and different domains of physical activity among young adult men
2022
BackgroundThere is limited evidence of how physical activity (PA) associates with low back pain (LBP) and neck pain (NP). Particularly, the association between occupational or commuting PA and LBP/NP is unclear. The aim of the present cross-sectional study was to investigate the association between spinal disorders and different physical activity domains in young and healthy adult men.MethodsSelf-reported leisure time, occupational and commuting PA, as well as LBP and NP, were studied using questionnaires among young Finnish males (n = 1,630). Logistic regression analysis was used to study the associations of PA domains, physical fitness, and spinal disorders. Regression models were adjuste…
Antecedentes y efectos del apego a la marca: papel moderador del posicionamiento de marca por atributo preeminente y de la implicación en la categorí…
2017
Cada día estamos expuestos a mayor cantidad de marcas, pocas sobresalen y menos aún generan apego emocional en sus usuarios. Aquellas que logran generar el apego emocional de sus consumidores, se benefician no solamente en cuanto a preferencia, lealtad y recompra, sino además en recomendaciones positivas, disposición a pagar un valor más alto por sus consumidores para poseerlas, y hasta tolerancia mayor con errores que la marca puede cometer. En este marco, la presente tesis persigue tres objetivos: (i) Explorar el impacto que cuatro antecedentes (personalidad de la marca, calidad percibida, notoriedad de marca y credibilidad de marca) y tres efectos (lealtad, intención de compra y riesgo p…