Search results for "3180*"
showing 10 items of 50 documents
Mountain building in NW Sicily from the superimposition of subsequent thrusting and folding events during Neogene: structural setting and tectonic ev…
2017
We present a 1:25.000 scale geological map of the Kumeta-Pizzuta ridge in north-western Sicily (Italy), achieved by integrating stratigraphic, structural and geophysical data. In this area, the tectonic edifice results from the piling-up of deep-water-, carbonate platform- and pelagic platform-derived tectonic units (Imerese and Sicilide, Panormide and Trapanese domains, respectively) resulting from deformations of the former southern Tethyan continental margin. The structural setting shows interference of tectonic events, different types of structural styles and different scales of deformational patterns. Early overthrust of the Imerese on the Trapanese units (since the late Serravallian) …
Quaternary marine and continental unconformity-bounded stratigraphic units of the NW Sicily coastal belt
2017
In the coastal sector of NW Sicily, the regional correlation of relevant unconformities recognised within the Quaternary sedimentary successions allowed the mapping of seven unconformity-bounded stratigraphic units (UBSUs). The regional unconformities are marine or subaerial erosional surfaces, as well as non-depositional surfaces, locally marked by paleosoils. The erosional surfaces were produced from marine abrasion, surface water overland/concentrated flow, river erosion, karst solution, mass movement, or wind erosion. The main lithofacies of the Quaternary UBSUs consist of: (a) marine and coastal bioclastic calcarenites, (b) aeolian sandstones, (c) river deposits, (d) colluvial deposits…
Cytological and molecular characterization of three gametoclones of Citrus clementina
2013
Abstract Background Three gametoclonal plants of Citrus clementina Hort. ex Tan., cv. Nules, designated ESP, FRA, and ITA (derived from three labs in Spain, France, and Italy, respectively), were selected for cytological and molecular characterization in order to elucidate genomic rearrangements provoked by haploidization. The study included comparisons of their ploidy, homozygosity, genome integrity, and gene dosage, using chromosome counting, flow cytometry, SSR marker genotyping, and array-Comparative Genomic Hybridization (array-CGH). Results Chromosome counting and flow cytometry revealed that ESP and FRA were haploid, but ITA was tri-haploid. Homozygous patterns, represented by a sing…
Effects of intrinsic aerobic capacity, aging and voluntary running on skeletal muscle sirtuins and heat shock proteins
2016
Aim Sirtuins are proteins that connect energy metabolism, oxidative stress and aging. Expression of heat shock proteins (Hsps) is regulated by heat shock factors (HSFs) in response to various environmental and physiological stresses, such as oxidative stress. Oxidative stress accumulates during aging which makes cells more prone to DNA damage. Although many experimental animal models have been designed to study the effects of knockdown or overexpression of sirtuins, HSFs and Hsps, little is known about how aging per se affects their expression. Here we study the impact of intrinsic aerobic capacity, aging and voluntary exercise on the levels of sirtuins, HSFs and Hsps in skeletal muscle. Me…
Improving Docking Performance Using Negative Image-Based Rescoring
2017
Despite the large computational costs of molecular docking, the default scoring functions are often unable to recognize the active hits from the inactive molecules in large-scale virtual screening experiments. Thus, even though a correct binding pose might be sampled during the docking, the active compound or its biologically relevant pose is not necessarily given high enough score to arouse the attention. Various rescoring and post-processing approaches have emerged for improving the docking performance. Here, it is shown that the very early enrichment (number of actives scored higher than 1% of the highest ranked decoys) can be improved on average 2.5-fold or even 8.7-fold by comparing th…
Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders
2018
International audience; C-reactive protein (CRP) is a sensitive biomarker of chronic low-grade inflammation and is associated with multiple complex diseases. The genetic determinants of chronic inflammation remain largely unknown, and the causal role of CRP in several clinical outcomes is debated. We performed two genome-wide association studies (GWASs), on HapMap and 1000 Genomes imputed data, of circulating amounts of CRP by using data from 88 studies comprising 204,402 European individuals. Additionally, we performed in silico functional analyses and Mendelian randomization analyses with several clinical outcomes. The GWAS meta-analyses of CRP revealed 58 distinct genetic loci (p < 5 × 1…
Microvesicle Formation Induced by Oxidative Stress in Human Erythrocytes
2020
Extracellular vesicles (EVs) released by different cell types play an important role in many physiological and pathophysiological processes. In physiological conditions, red blood cell (RBC)-derived EVs compose 4&ndash
Additives for vaccine storage to improve thermal stability of adenoviruses from hours to months
2016
Up to 80% of the cost of vaccination programmes is due to the cold chain problem (that is, keeping vaccines cold). Inexpensive, biocompatible additives to slow down the degradation of virus particles would address the problem. Here we propose and characterize additives that, already at very low concentrations, improve the storage time of adenovirus type 5. Anionic gold nanoparticles (10−8–10−6 M) or polyethylene glycol (PEG, molecular weight ∼8,000 Da, 10−7–10−4 M) increase the half-life of a green fluorescent protein expressing adenovirus from ∼48 h to 21 days at 37 °C (from 7 to >30 days at room temperature). They replicate the known stabilizing effect of sucrose, but at several orders of…
New national and regional Annex I Habitat records: From #26 to #36
2021
New Italian data on the distribution of the Annex I Habitats 1510*, 2130*, 2250*, 3180*, 3260, 5230*, 6410, 7140, 7220*, 9320 are reported in this contribution. Specifically, 14 new occurrences in Natura 2000 sites are presented and 20 new cells are added in the EEA 10 km × 10 km reference grid. The new data refer to the Italian administrative regions of Abruzzo, Apulia, Friuli Venezia Giulia, Liguria, Marche, Molise, Sardinia, Sicily, Tuscany and Umbria.
Spiking Neural Networks models targeted for implementation on Reconfigurable Hardware
2017
La tesis presentada se centra en la denominada tercera generación de redes neuronales artificiales, las Redes Neuronales Spiking (SNN) también llamadas ‘de espigas’ o ‘de eventos’. Este campo de investigación se convirtió en un tema popular e importante en la última década debido al progreso de la neurociencia computacional. Las Redes Neuronales Spiking, que tienen no sólo la plasticidad espacial sino también temporal, ofrecen una alternativa prometedora a las redes neuronales artificiales clásicas (ANN) y están más cerca de la operación real de las neuronas biológicas ya que la información se codifica y transmite usando múltiples espigas o eventos en forma de trenes de pulsos. Este campo h…