Search results for "31"
showing 10 items of 4401 documents
Structure of SNX9 SH3 in complex with a viral ligand reveals the molecular basis of its unique specificity for alanine-containing class I SH3 motifs
2021
Class I SH3 domain-binding motifs generally comply with the consensus sequence [R/K]x0PxxP, the hydrophobic residue 0 being proline or leucine. We have studied the unusual 0 = Ala-specificity of SNX9 SH3 by determining its complex structure with a peptide present in eastern equine encephalitis virus (EEEV) nsP3. The structure revealed the length and composition of the n-Src loop as important factors determining specificity. We also compared the affinities of EEEV nsP3 peptide, its mutants, and cellular ligands to SNX9 SH3. These data suggest that nsP3 has evolved to minimize reduction of conformational entropy upon binding, hence acquiring stronger affinity, enabling takeover of SNX9. The R…
The primary structural photoresponse of phytochrome proteins captured by a femtosecond X-ray laser
2019
Phytochrome proteins control the growth, reproduction, and photosynthesis of plants, fungi, and bacteria. Light is detected by a bilin cofactor, but it remains elusive how this leads to activation of the protein through structural changes. We present serial femtosecond X-ray crystallographic data of the chromophore-binding domains of a bacterial phytochrome at delay times of 1 ps and 10 ps after photoexcitation. The data reveal a twist of the D-ring, which leads to partial detachment of the chromophore from the protein. Unexpectedly, the conserved so-called pyrrole water is photodissociated from the chromophore, concomitant with movement of the A-ring and a key signaling aspartate. The chan…
Teachers as frontline agents of integration: Finnish physical education students’ reflections on intercultural encounters
2018
Background and purpose: This article focuses on how future Physical Education and Dance teachers may be better prepared to work in increasingly diverse education environments. It also discusses how tertiary institutions might address issues of social inclusion and cultural pluralism within their programmes, courses and assignments. The authors critically reflect on an experiential learning intervention in Jyväskylä, Finland, in which trainee PE teachers facilitated kinaesthetic language-learning workshops for asylum seekers. The applied use of physical education and dance in this context was aimed at providing a distinct opportunity to consider a PE teacher’s professional competence and rol…
Cultures in Dialogue: Perceptions and Experiences of Finnish Teachers of Transnational Dances
2012
This article is based on a phenomenographic study that focuses on identifying the pedagogical conceptions of Finnish teachers of transnational dances. The purpose is to uncover and understand teachers' conceptions concerning the implications of the cultural contexts of their specific dance forms for their pedagogical practices. Through a process of phenomenographic data analysis, the authors have identified three different ways to understand teachers' conceptions and experiences: (1) Dance as a path towards personal expression, (2) Telling a story of being a woman through dance, and (3) Self-approval and the collective nature of dance. The study aims at facilitating discussion about the pro…
Emotions in motion: Short-term group form Dance/Movement Therapy in the treatment of depression: A pilot study
2014
Abstract Depression is a highly prevalent mood disorder that impairs a person's social skills and quality of life. Depressed patients have been shown to have difficulty in identifying, expressing, and regulating emotions, especially negative emotions, such as anger. Here, we present a study that investigates using body- and movement-based therapy intervention in the treatment of depression. Central to this study is the use of a short-term group form of Dance/Movement Therapy (DMT) intervention. The main research question was whether a short-term group form of DMT intervention could decrease the symptoms of depression and anxiety. Depressed participants ( N = 21, aged 18–60 years) received …
Emotion-driven encoding of music preference and personality in dance
2014
Thirty rhythmic music excerpts were presented to 60 individuals. Dance movements to each excerpt were recorded using an optical motion-capture system, preference for each excerpt recorded on a 5-point Likert scale, and personality assessed using the 44-item version of the Big Five Inventory. From the movement data, a large number of postural, kinematic and kinetic features were extracted, a subset of which were chosen for further analysis using sequential backward elimination with variance inflation factor (VIF) selection. Multivariate analyses revealed significant effects on these 11 features of both preference and personality, as well as a number of interactions between the two. As regar…
Dance Like Someone is Watching
2018
Although dancing often takes place in social contexts such as a club or party, previous study of such music-induced movement has focused mainly on individuals. The current study explores music-induced movement in a naturalistic dyadic context, focusing on the influence of personality, using five-factor model (FFM) traits, and trait empathy on participants’ responses to their partners. Fifty-four participants were recorded using motion capture while dancing to music excerpts alone and in dyads with three different partners, using a round-robin approach. Analysis using the Social Relations Model (SRM) suggested that the unique combination of each pair caused more variation in participants’ a…
Change in weight and central obesity by positive airway pressure treatment in obstructive sleep apnea patients: longitudinal data from the ESADA coho…
2018
The effect of positive airway pressure treatment on weight and markers of central obesity in patients with obstructive sleep apnea remains unclear. We studied the change in body weight and anthropometric measures following positive airway pressure treatment in a large clinical cohort. Patients with obstructive sleep apnea with positive airway pressure treatment from the European Sleep Apnea Database registry (n = 1, 415, 77% male, age 54 ± 11 [mean ± SD] years, body mass index 31.7 ± 6.4 kg/m2, apnea–hypopnea index 37 ± 24 n per hr, Epworth Sleepiness Scale 10.2 ± 5.0) were selected. Changes in body mass index and neck/waist/hip circumferences at baseline and at follow-up visit were analyse…
Maternal body mass index, gestational weight gain, and the risk of overweight and obesity across childhood: An individual participant data meta-analy…
2019
Background Maternal obesity and excessive gestational weight gain may have persistent effects on offspring fat development. However, it remains unclear whether these effects differ by severity of obesity, and whether these effects are restricted to the extremes of maternal body mass index (BMI) and gestational weight gain. We aimed to assess the separate and combined associations of maternal BMI and gestational weight gain with the risk of overweight/obesity throughout childhood, and their population impact. Methods and findings We conducted an individual participant data meta-analysis of data from 162,129 mothers and their children from 37 pregnancy and birth cohort studies from Europe, No…
BioTIME: A database of biodiversity time series for the Anthropocene
2018
Abstract Motivation The BioTIME database contains raw data on species identities and abundances in ecological assemblages through time. These data enable users to calculate temporal trends in biodiversity within and amongst assemblages using a broad range of metrics. BioTIME is being developed as a community-led open-source database of biodiversity time series. Our goal is to accelerate and facilitate quantitative analysis of temporal patterns of biodiversity in the Anthropocene. Main types of variables included The database contains 8,777,413 species abundance records, from assemblages consistently sampled for a minimum of 2 years, which need not necessarily be consecutive. In addition, th…