Search results for "31"
showing 10 items of 4401 documents
ARIA‐EAACI care pathways for allergen immunotherapy in respiratory allergy
2021
Funding Information: BSreports personal fees from Allergopharma, during the conduct of the study; grants from National Health Programm, grant, personal fees from Polpharma, ASTRA, personal fees from Mylan, Adamed, patient ombudsman, national Centre for Research and Development, Polish Allergology Society. Funding Information: NGP reports personal fees from Novartis, Nutricia, HAL, MENARINI/FAES FARMA, SANOFI, MYLAN/MEDA, BIOMAY, AstraZeneca, GSK, MSD, ASIT BIOTECH, Boehringer Ingelheim, grants from Gerolymatos International SA, Capricare. Funding Information: CA reports grants from Allergopharma, grants from Idorsia, Swiss National Science Foundation, Christine Kühne‐Center for Allergy Rese…
A comprehensive evaluation of potential lung function associated genes in the SpiroMeta general population sample
2011
Lung function measures are heritable traits that predict population morbidity and mortality and are essential for the diagnosis of chronic obstructive pulmonary disease (COPD). Variations in many genes have been reported to affect these traits, but attempts at replication have provided conflicting results. Recently, we undertook a meta-analysis of Genome Wide Association Study (GWAS) results for lung function measures in 20,288 individuals from the general population (the SpiroMeta consortium). OBJECTIVES: To comprehensively analyse previously reported genetic associations with lung function measures, and to investigate whether single nucleotide polymorphisms (SNPs) in these genomic regions…
Scaling up strategies of the chronic respiratory disease programme of the European Innovation Partnership on Active and Healthy Ageing (Action Plan B…
2016
Action Plan B3 of the European Innovation Partnership on Active and Healthy Ageing (EIP on AHA) focuses on the integrated care of chronic diseases. Area 5 (Care Pathways) was initiated using chronic respiratory diseases as a model. The chronic respiratory disease action plan includes (1) AIRWAYS integrated care pathways (ICPs), (2) the joint initiative between the Reference site MACVIA-LR (Contre les MAladies Chroniques pour un VIeillissement Actif) and ARIA (Allergic Rhinitis and its Impact on Asthma), (3) Commitments for Action to the European Innovation Partnership on Active and Healthy Ageing and the AIRWAYS ICPs network. It is deployed in collaboration with the World Health Organizatio…
Hardy inequalities and Assouad dimensions
2017
We establish both sufficient and necessary conditions for weighted Hardy inequalities in metric spaces in terms of Assouad (co)dimensions. Our sufficient conditions in the case where the complement is thin are new even in Euclidean spaces, while in the case of a thick complement we give new formulations for previously known sufficient conditions which reveal a natural duality between these two cases. Our necessary conditions are rather straight-forward generalizations from the unweighted case, but together with some examples they indicate the essential sharpness of our results. In addition, we consider the mixed case where the complement may contain both thick and thin parts.
Existence and almost uniqueness for p -harmonic Green functions on bounded domains in metric spaces
2020
We study ($p$-harmonic) singular functions, defined by means of upper gradients, in bounded domains in metric measure spaces. It is shown that singular functions exist if and only if the complement of the domain has positive capacity, and that they satisfy very precise capacitary identities for superlevel sets. Suitably normalized singular functions are called Green functions. Uniqueness of Green functions is largely an open problem beyond unweighted $\mathbf{R}^n$, but we show that all Green functions (in a given domain and with the same singularity) are comparable. As a consequence, for $p$-harmonic functions with a given pole we obtain a similar comparison result near the pole. Various c…
Algebraic time-reversal operation
1999
International audience; We analyze the implementation of the time-reversal (TR) transformation in the algebraic approach to tetrahedral local molecules through the chain of groups U(5) U(4) K(4) = A(4) ^ S(4) S(4) Td. We determine the general form of the TR operation using a purely algebraic realization, based exclusively on the requirement that the irreducible representations must not be changed under the time inversion symmetry. As a result we can determine the TR behavior of purely algebraic operators.
Self-improvement of pointwise Hardy inequality
2019
We prove the self-improvement of a pointwise p p -Hardy inequality. The proof relies on maximal function techniques and a characterization of the inequality by curves.
Improved Bounds for Hermite–Hadamard Inequalities in Higher Dimensions
2019
Let $\Omega \subset \mathbb{R}^n$ be a convex domain and let $f:\Omega \rightarrow \mathbb{R}$ be a positive, subharmonic function (i.e. $\Delta f \geq 0$). Then $$ \frac{1}{|\Omega|} \int_{\Omega}{f dx} \leq \frac{c_n}{ |\partial \Omega| } \int_{\partial \Omega}{ f d\sigma},$$ where $c_n \leq 2n^{3/2}$. This inequality was previously only known for convex functions with a much larger constant. We also show that the optimal constant satisfies $c_n \geq n-1$. As a byproduct, we establish a sharp geometric inequality for two convex domains where one contains the other $ \Omega_2 \subset \Omega_1 \subset \mathbb{R}^n$: $$ \frac{|\partial \Omega_1|}{|\Omega_1|} \frac{| \Omega_2|}{|\partial \Ome…
On the interior regularity of weak solutions to the 2-D incompressible Euler equations
2016
We study whether some of the non-physical properties observed for weak solutions of the incompressible Euler equations can be ruled out by studying the vorticity formulation. Our main contribution is in developing an interior regularity method in the spirit of De Giorgi–Nash–Moser, showing that local weak solutions are exponentially integrable, uniformly in time, under minimal integrability conditions. This is a Serrin-type interior regularity result $$\begin{aligned} u \in L_\mathrm{loc}^{2+\varepsilon }(\Omega _T) \implies \mathrm{local\ regularity} \end{aligned}$$ for weak solutions in the energy space $$L_t^\infty L_x^2$$ , satisfying appropriate vorticity estimates. We also obtain impr…
Sharp estimate on the inner distance in planar domains
2020
We show that the inner distance inside a bounded planar domain is at most the one-dimensional Hausdorff measure of the boundary of the domain. We prove this sharp result by establishing an improved Painlev\'e length estimate for connected sets and by using the metric removability of totally disconnected sets, proven by Kalmykov, Kovalev, and Rajala. We also give a totally disconnected example showing that for general sets the Painlev\'e length bound $\kappa(E) \le\pi \mathcal{H}^1(E)$ is sharp.