Search results for "31"
showing 10 items of 4401 documents
Comparison of Immunosuppressive and Angiogenic Properties of Human Amnion-Derived Mesenchymal Stem Cells between 2D and 3D Culture Systems
2019
The secretion of potential therapeutic factors by mesenchymal stem cells (MSCs) has aroused much interest given the benefits that it can bring in the field of regenerative medicine. Indeed, the in vitro multipotency of these cells and the secretive capacity of both angiogenic and immunomodulatory factors suggest a role in tissue repair and regeneration. However, during culture, MSCs rapidly lose the expression of key transcription factors associated with multipotency and self-renewal, as well as the ability to produce functional paracrine factors. In our study, we show that a three-dimensional (3D) culture method is effective to induce MSC spheroid formation, to maintain the multipotency an…
Neural Stem Cells in the Adult Brain: From Benchside to Clinic
2012
Increasing evidence indicates that neural stem cells (NSCs) play an important role in sustaining cellular homeostasis and brain tissue restoration. The study of all mechanisms that control and modulate the function of NSC is a crucial step for the design of therapies against chronic neurodegenerative processes. In this special issue of the journal, we had the pleasure to edit the topic entitled “Neural Stem Cells in the Adult Brain: From Benchside to Clinic.” This special compilation of paper was aimed to provide a global forum for publications of original peer-reviewed manuscripts that reported original research findings in the field of adult neural stem cell, including short communication…
Vγ9Vδ2 T cells as a promising innovative tool for immunotherapy of hematologic malignancies
2011
The potent anti-tumor activities of γδ T cells, their ability to produce pro-inflammatory cytokines, and their strong cytolytic activity have prompted the development of protocols in which γδ agonists or ex vivo-expanded γδ cells are administered to tumor patients. γδ T cells can be selectively activated by either synthetic phosphoantigens or by drugs that enhance their accumulation into stressed cells as aminobisphosphonates, thus offering new avenues for the development of γδ T cell-based immunotherapies. The recent development of small drugs selectively activating Vγ9Vδ2 T lymphocytes, which upregulate the endogenous phosphoantigens, has enabled the investigators to design the experiment…
Low molecular weight heparins in cancer patients: to treat thromboembolic events, the tumor, or both?
2011
The interrelationship between cancer and thrombosis is well known. Recent data help physicians to optimize the management of thrombotic complications occurring in cancer patients. However, many issues are still uncertain. First, although the development of venous thromboembolism (VTE) in a patient with known cancer is the most common presentation, concerns remain about the optimal duration and dosages of anticoagulants. Questions also arise concerning the need to implement heparin prophylaxis in the course of chemotherapy. Secondly, in some patients, thrombosis precedes the diagnosis of malignancy. In this case, the question is whether or not to screen patients for an occult cancer. Thirdly…
Overweight Adolescents’ Self-Perceived Weight and Weight Control Behaviour: HBSC Study in Finland 1994–2010
2012
Introduction. Overweight and perception of being overweight, may lead adolescent to lose weight. The aim of the present study was to investigate overweight adolescents’ self-perceived weight, body dissatisfaction, and weight control behaviour during 1994–2010 in Finland.Methods. The country-representative, cross-sectional data of 15-year olds were obtained from the Health Behaviour in School-aged Children (HBSC) study, conducted in 1994 (; males: 48%), 1998 (; 49%), 2002 (; 50%), 2006 (; 47%), and 2010 (; 48%).Results. The majority of overweight boys (62–69%) and girls (89–100%) assessed themselves as too fat, and their body image was lower than in nonoverweight adolescents. The highest pre…
Advanced chronic kidney disease. Association between anxiety, depression and resilience
2019
Resumen Introducción: el padecimiento de la enfermedad renal crónica avanzada (ERCA) se asocia con una mayor probabilidad de padecer sintomatología depresiva y ansiosa. No obstante, la resiliencia puede amortiguar estos efectos. El objetivo general fue valorar la sintomatología ansiosa, depresiva y la resiliencia de los pacientes con ERCA. Métodos: 70 pacientes (80 % varones), con edades entre 38-88 años (M=68,88; DT= 9,98) fueron evaluados mediante la Escala Hospitalaria de Ansiedad y Depresión y la de Resiliencia de Connor Davidson. Se realizaron análisis descriptivos, pruebas t, d de Cohen y correlaciones de Pearson. Resultados: un 41,79 % presentó sintomatología ansiosa y un 25,38 % dep…
«Enfre la vinya e·l fenollar»? La composició del «Llibre d'Amic e Amat» i l'experiència mística de Ramon Llull
1992
The essay's main purpose is to eradicate the topic that the Blaquerna is in fact Llull’s autobiography and that the LAA reflects in a direct way R. Llull's mystical experience. While the LAA fits perfectly the general structure of the Blaquerna and could very well nave originally been conceived as a part of this novel, the evidence so far available seems to indicate that the LAA never existed as an independent text.
El «llibre cortés de lectura» en català: a propòsit del manuscrit F-129 del Col·legi de la Sapiència de Palma
2006
The manuscript F-129 of the Col·legi de la Sapiència de Palma contains three works of Ramon Llull. It is made up of two separate manuscripts belonging to the first generation of Lullian codices (that is, not later than the first quarter of the fourteenth century). This collection is preceded by a remarkable full-page illustration, an analysis of which shows that it was probably based on a similar miniature from a French codex emanating from Llull’s immediate circle. The codicological model applicable to this manuscrit is that of «libro cortese di lettura».
Is it me or the music? : Stress reduction and the role of regulation strategies and music
2019
Music is a common resource for the regulation of emotions, moods, and stress. This study aimed at determining the individual and relative impact on stress reduction of two of the main factors involved in musical affect regulation: regulation strategies and music itself. The current study took place in an experimental setting and followed a factorial within-subjects design. First, the participants ( n = 34) filled in an online survey where they identified their self-perceived “adequate”/“inadequate” music examples for the purpose of reducing stress and self-perceived “adequate”/“inadequate” strategies for the same purpose. In the lab they went through a stress induction procedure and then w…
Access-Awareness-Agency (AAA) Model of Music-Based Social-Emotional Competence (MuSEC)
2019
Social–emotional competence (SEC) is a set of psychological resources, highly relevant for adaptive growth and wellbeing. Music has been argued to support social–emotional skills, yet there is little theoretical consensus about the underlying impact mechanisms and the special nature of music as a medium for SEC. This article presents a theoretical model of music-based SEC that combines research from general SEC models with music-specific literature from music psychology, music education, music therapy, and music for health and wellbeing. The proposed access-awareness-agency (AAA) model defines music-based social–emotional competence (MuSEC) as interplay of embodied access, reflective awaren…