Search results for "31"

Expert Opinion on Three Phage Therapy Related Topics: Bacterial Phage Resistance, Phage Training and Prophages in Bacterial Production Strain

2018

Bartomeu de Tresbens, physician and astrologer in the service of king Peter the Ceremonious and the infant John: between the service to the Crown and…

2018

Bartomeu de Tresbens was a physician, astrologer and philosopher at the service of two kings of the Crown of Aragon, Peter IV the Ceremonious and his son, Duke John, the future John I the Hunter, between 1360 and 1375, approximately. His major work of astrological content has hardly been studied, except for the Llibre de les nativitats (Book of Nativities). Similarly, most of his biography is not known. The documents, which are mainly the correspondence of its relationship with the monarchy, are preserved, but also other records that connect him to the municipalities of Barcelona and Cervera. Particularly in the latter case, Tresbens was tempted by the municipal authorities for being the ph…

Cardiorespiratory Fitness and the Risk of Serious Ventricular Arrhythmias: A Prospective Cohort Study.

2019

Cardiorespiratory fitness (CRF) is an established risk factor for cardiovascular disease outcomes. However, the relationship of CRF with risk of ventricular arrhythmias (VAs) is unknown. We aimed to assess the prospective association of CRF with the risk of serious VAs. Cardiorespiratory fitness, as measured by maximal oxygen uptake, was assessed using a respiratory gas exchange analyzer in 2299 middle-aged men in the Kuopio Ischemic Heart Disease prospective cohort. We corrected for within-person variability in CRF levels using data from repeated measurements 11 years apart. During median follow-up of 25.3 years (interquartile range, 18.7-27.2 years), 73 serious VAs were recorded. The age-…

Forensic Analysis of Fire in a Substation of a Commercial Center

2020

In this article, the authors discuss the legal liabilities of the professional engineer as both the engineer of record of a project and the construction site manager. In particular, this article analyzes the case of a fire at the end-user medium voltage–low-voltage (MV–LV) substation of a shopping center in Italy, which occurred a few years after the maintenance works on the electrical installation. The professional engineer who had designed and overseen the construction of the substation was accused of professional negligence. The authors through the examination of applicable technical standards, as well as of safety regulations, demonstrate that the professional engineer had acted diligen…

Safety and immunogenicity of the therapeutic vaccine TG1050 in chronic hepatitis B patients: a phase 1b placebo-controlled trial

2020

Funding: Transgène; International audience; Treatment of chronic hepatitis B (CHB) typically requires life-long administration of drugs. Cohort and pre-clinical studies have established the link between a functional T-cell-mounted immunity and resolution of infection. TG1050 is an adenovirus 5-based vaccine that expresses HBV polymerase and domains of core and surface antigen and has shown immunogenicity and antiviral effects in mice. We performed a phase 1 clinical trial to assess safety and explore immunogenicity and early efficacy of TG1050 in CHB patients. This randomized, double blind, placebo-controlled study included two sequential phases: one single dose cohort (SD, n = 12) and one …

High training volume is associated with increased prevalence of non-allergic asthma in competitive cross-country skiers.

2022

BackgroundCross-country skiers have a high prevalence of asthma, but its phenotypes and association with success in competitions are not known.ObjectiveTo investigate, by means of a postal survey, the relative proportions of allergic and non-allergic asthma in competitive cross-country skiers compared with the general population, to study how performance level and training volume are related to asthma and its type and to assess the possible risk factors for allergic and non-allergic asthma in competitive skiers.MethodsAll Finnish cross-country skiers enrolled in the largest national competitions in winter 2019 (n=1282), and a random sample (n=1754) of the general population of the same age …

Brief an Johann Gottfried Herder

1797

Samfunnsansvar, veldedighet og omdømme : en studie av samfunnsansvar som veldedighet i Capgemini Norge

2016

Masteroppgave samfunnskommunikasjon- Universitetet i Agder, 2016 I denne studien undersøkes det hva bedriftens samfunnsansvar er, og hvorfor Capgemini Norge engasjerer seg i bedriftens samfunnsansvar. Som teoretisk rammeverk har jeg benyttet meg av sentral litteratur på fagområdene samfunnsansvar, veldedighet, strategisk samfunnsansvar og omdømme. Spesielt sentral i samfunnsansvarsdebatten står økonomen Archie B. Carroll og hans forklaring på hva bedrifters samfunnsansvar innebærer. Om samfunnsansvar i Norge baserer oppgaven seg i stor grad på perspektivene til Ditlev- Simonsen og Midttun (2010). Teoriene som presenteres er ment å brukes til å få i gang en fruktbar diskusjon av problemstill…

Age and Muscle Function Are More Closely Associated With Intracellular Magnesium, as Assessed by

2019

Total serum magnesium is a common clinical measurement for assessing magnesium status; however, magnesium in blood represents less than 1% of the body’s total magnesium content. We measured intramuscular ionized magnesium by phosphorus magnetic resonance spectroscopy (31P-MRS) and tested the hypothesis that this measure better correlates with skeletal muscle function and captures more closely the effect of aging than the traditional measure of total serum magnesium. Data were collected from 441 participants (age 24–98 years) in the Baltimore Longitudinal Study of Aging (BLSA), a study of normative aging that encompasses a broad age range. Results showed that intramuscular ionized magnesium …

A New Development in Online Marketing: Introducing Digital Inbound Marketing

2015

This paper addresses the conceptualization, scale development and scale validation related to the study of consumer engagement in online settings. It first reviews this concept and draws attention to the multidimensionality of the construct, considering the underlying cognitive, emotional, and behavioral dimensions of consumer engagement. Then, it presents the foundation of this concept in relationship marketing and adds support to this proposition. Further, it proposes the construction and psychometric assessment of a 37 scales that examine all three dimensions, based on an international sample of 110 respondents who engage with a brand on a social media network. Based on multiple and succ…