Search results for "320"
showing 10 items of 338 documents
Neuronal structural plasticity in the Medial Prefrontal Cortex: regulation by Dopamine and PSA-NCAM
2011
Although there is a decline in brain plasticity across lifespan, neurons in certain areas of the adult brain retain the ability to undergo synaptic, dendritic and spine remodeling in response to different stimuli. This neuronal structural plasticity seems to be the basis for many cognitive processes and it is crucial for adaptive responses to aversive experiences and recovery from brain damage and disease. Among the numerous candidate molecules that have been identified for mediating this neuronal remodeling, cell adhesion molecules and, specially, the neural cell adhesion molecule (NCAM), are of particular interest. The addition of polysialic acid (PSA) to the NCAM is critical for the stru…
Relevancia de la autofagia en la toxicidad de los antiinflamatorios no esteroideos sobre el epitelio digestivo
2017
Los antiinflamatorios no esteroideos (AINE) constituyen uno de los grupos de medicamentos más consumidos en el mundo por sus acciones antiinflamatoria, analgésica y antipirética, y, en consecuencia, sus reacciones adversas tienen una gran repercusión en la población. Su mecanismo de acción consiste en la inhibición de las enzimas ciclooxigenasas y el consecuente descenso en los niveles de prostanoides. Si la implicación de estos mediadores en la inflamación, el dolor y la fiebre justifica las acciones farmacológicas, su rol en funciones fisiológicas explica su perfil de efectos secundarios. Entre sus reacciones adversas merecen una mención especial las que ocurren a nivel gastrointestinal, …
Perceived support in e-collaborative learning: An exploratory study which make use of synchronous and asynchronous online-teaching approaches
2012
Published version of a chapter in the book: Advances in Web-Based Learning - ICWL 2012. Also available from the publisher at: http://dx.doi.org/10.1007/978-3-642-33642-3_2 This study compares four different learning environments for e-collaborative learning in two European countries related to the dimension of student’s mutual support. The theoretical baseline is Vygotsky’s zone of proximal development (ZOPD) and the socio-genetic approach of Piaget. The analyzed data are based on questionnaires collected over the time period of an entire semester including four different courses at the master’s level. These courses applied different e-collaborative approaches including a variety of tools f…
The Genre System Lens on E-Democracy
2008
Published version of an article published in Scandinavian Journal of Information Systems, 20 (2), 51-82. Also available from the publisher at: http://aisel.aisnet.org/sjis/vol20/iss2/3 E-Democracy aims at enhancing citizen involvement in societal communication and decision making. However, the very ideals of democracy vary while reports of e-democracy in use have often left them undiscussed. Moreover, theoretical works on the potential of information technology (IT) for democratization have often viewed IT as a “black box”, and assumed that technology should create an impact as such. Hence, there is a dearth of research on the interplay between models of e-democracy and actual IT artefacts …
Linking employer branding orientation and firm performance: Testing a dual mediation route of recruitment efficiency and positive affective climate
2019
Faced with competitive labor markets, firms increasingly use employer branding to build a qualified workforce and engage their employees. However, our understanding of the impact of employer branding orientation on firm performance and the theoretical firm‐level mechanisms underlying this potential impact is very limited. To address this gap, we integrate brand marketing theory with human resource management (HRM) research to develop a model explicating how employer branding orientation is linked to firm performance through a dual route by enhancing both recruitment efficiency (i.e., external route: applicants) and positive affective climate (i.e., internal route: incumbent employees). The …
Medicine of the future: How and who is going to treat us?
2023
Medicine’s ability to quickly respond to challenges raises questions from researchers, practitioners, and society as a whole. Our task in this study was to identify key and atypical current factors influencing the development of medicine and to predict the development of medicine in the short, medium, and long term. To implement our study, we selected 22 medical experts and applied the three-level Delphi method. The current trends caused by COVID-19 have a short-term impact, but they will launch other drivers that will transform the healthcare industry. Well-being technologies, data-informed personalization, and climate change will become key drivers for the development of medicine over the…
De la conscience fière au stigmate social : le virilisme ouvrier à l’épreuve des années 1968
2014
La masculinité ouvrière, en tant que caractère(s) du masculin, ressortit, on le sait, au virilisme : l’exhibition du corps fort liée à la dureté du travail, une manière d’exacerbation de la masculinité, relèvent de la culture ouvrière. Dès lors, le virilisme désignerait en première approche une forme d’ostentation de la virilité, qui en vient à faire système : non pas seulement l’exaltation de vertus masculines supposées – force, courage, endurance, etc., mais aussi réflexion, sagacité, etc. ...
Implementing Intranet 2.0: A Study of Knowledge Requirements for External Consultants in Enterprise Systems
2014
Published article from the series: Procedia Technology. Also available on Science Direct: http://dx.doi.org/10.1016/j.protcy.2014.10.018 Open Access This paper reports on a case study focusing on intranet implementation projects seen from a consultancy lens. SharePoint is an Intranet 2.0 platform which is a user-centric system based on functionalities adapted from Web 2.0 technologies. Intranet implementation projects are accompanied by a complex socio-technical organizational environment, and require changes in organizational structure and culture. While former studies mainly have focused on challenges seen from the implementing organization's perspective, this study focuses on the experie…
A Historical Analysis of Media Practices and Technologies in Protest Movements : A Review of Crisis and Critique by Anne Kaun
2017
Dr. Anne Kaun’s book, <em>Crisis and Critique: A Brief History of Media Participation in Times of Crisis</em> (London: Zed Books, 2016, 131 pp., ISBN: 978-1-78360-736-5), is a concise but comprehensive analysis of the changing media practices and technologies in protest movements. The book overviews the topic within the context of major economic crises and scrutinises three richly detailed case studies in the United States: (a) the unemployed workers’ movement during the Great Depression in the 1930s, (b) the tenants’ rent strike movement of the early 1970s, and (c) the Occupy Wall Street movement following the Great Recession of 2008. Kaun begins her book with an introduction t…
The Two-Systems Account of Theory of Mind: Testing the Links to Social- Perceptual and Cognitive Abilities
2018
According to the two-systems account of theory of mind (ToM), understanding mental states of others involves both fast social-perceptual processes, as well as slower, reflexive cognitive operations (Frith and Frith, 2008; Apperly and Butterfill, 2009). To test the respective roles of specific abilities in either of these processes we administered 15 experimental procedures to a large sample of 343 participants, testing ability in face recognition and holistic perception, language, and reasoning. ToM was measured by a set of tasks requiring ability to track and to infer complex emotional and mental states of others from faces, eyes, spoken language, and prosody. We used structural equation m…