Search results for "346"
showing 10 items of 252 documents
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
2011
Multiple sclerosis is a common disease of the central nervous system in which the interplay between inflammatory and neurodegenerative processes typically results in intermittent neurological disturbance followed by progressive accumulation of disability. Epidemiological studies have shown that genetic factors are primarily responsible for the substantially increased frequency of the disease seen in the relatives of affected individuals, and systematic attempts to identify linkage in multiplex families have confirmed that variation within the major histocompatibility complex (MHC) exerts the greatest individual effect on risk. Modestly powered genome-wide association studies (GWAS) have ena…
Correction to: Depletion of regulatory T cells increases T cell brain infiltration, reactive astrogliosis, and interferon-γ gene expression in acute …
2019
Traumatic brain injury (TBI) is a major cause of death and disability. T cells were shown to infiltrate the brain during the first days after injury and to exacerbate tissue damage. The objective of this study was to investigate the hitherto unresolved role of immunosuppressive, regulatory T cells (Tregs) in experimental TBI."Depletion of regulatory T cell" (DEREG) and wild type (WT) C57Bl/6 mice, treated with diphtheria toxin (DTx) to deplete Tregs or to serve as control, were subjected to the controlled cortical impact (CCI) model of TBI. Neurological and motor deficits were examined until 5 days post-injury (dpi). At the 5 dpi endpoint, (immuno-) histological, protein, and gene expressio…
Zvaigžņotā Debess: 2005, Vasara
2005
Contents: In memoriam Arturs Balklavs-Grīnhofs ; Parting Words to Arturs Balklavs ; List of Publications by Prof. Dr.phys. Arturs Balklavs-Grīnhofs ; Astronomy in 25 Years of Soviet Latvia ; Man in Space: Based on newspaper “Pravda” materials ; U.Dzērvītis. Centenary of the Theory of Relativity ; A.Balklavs. Gamma Emission from the Galactic Centre ; A.Alksnis, Z.Alksne. Fewer Brown Dwarfs, More Red Ones ; A.Alksnis. New Observations of the Eruptive Variable Star V838 Mon ; A.Balklavs. Cosmic Objects in Captivating Photos – 5 ; J. Freimanis. On Polarization of Continuous Solar Spectrum ; J.Jaunbergs. The Very First Contact with Titan ; A.Millers. Biological Effects of Cosmic Rays ; J.Jansons…
Is There a Future for Non-invasive Brain Stimulation as a Therapeutic Tool?
2019
Several techniques and protocols of non-invasive transcranial brain stimulation (NIBS), including transcranial magnetic and electrical stimuli, have been developed in the past decades. These techniques can induce long lasting changes in cortical excitability by promoting synaptic plasticity and thus may represent a therapeutic option in neuropsychiatric disorders. On the other hand, despite these techniques have become popular, the fragility and variability of the after effects are the major challenges that non-invasive transcranial brain stimulation currentlyfaces. Several factors may account for such a variability such as biological variations, measurement reproducibility, and the neurona…
Trunk Muscle Strength After Lumbar Spine Fusion: A 12-Month Follow-up.
2019
Objective: The aim of this study was to investigate changes in trunk muscle strength 12 months after lumbar spine fusion (LSF) compared to preoperative strength. Methods: A total of 194 patients (mean ± standard deviation [SD] age, 61 ± 21 years) who underwent LSF participated in this prospective longitudinal study. Physical measurements of the participants were made before surgery and 12 months postoperatively. Isometric trunk extension and flexion strength was measured using a strain-gauge dynamometer in the standing position. Strength changes were calculated. Regression analysis was performed to explore which factors predicted strength levels at 12 months postoperatively. Results: The pr…
"Pārrobežu maksātnespējas procesa problēmas"
2016
Maģistra darbā „Pārrobežu maksātnespējas procesa problēmas” pētīti maksātnespējas procesi, kuros piemēro Eiropas parlamenta un Padomes Regulas (EK) Nr.1346/2000 par pārrobežu maksātnespējas procedūrām normas. Darbā pētīta regulas piemērošanas prakse Latvijas un Eiropas Savienības valstu tiesās. Pētījuma mērķis: izpētīt pārrobežu maksātnespējas procesa problēmas. Pētījuma uzdevumi: izpētīt pārrobežu maksātnespējas procesu tiesisko regulējumu; galvenā interešu centra noteikšanas problēmas; kreditoru tiesību un informācijas nodrošināšanas problēmas. Pētījuma rezultāti liecina, ka pārrobežu maksātnespējas procesa problēmas Latvijas praksē nav identificētas pietiekošā mērā, tiesas piemēro atšķir…
Effect of the CB1 cannabinoid agonist WIN 55212-2 on the acquisition and reinstatement of MDMA-induced conditioned place preference in mice
2010
AbstractBackgroundNumerous reports indicate that MDMA users consume other psychoactive drugs, among which cannabis is one of the most common. The aim of the present study was to evaluate, using the conditioned place preference, the effect of the cannabinoid agonist WIN 55,212-2 on the rewarding effects of MDMA in mice.MethodsIn the first experiment adolescent mice were initially conditioned with 1.25, 2.5 or 5 mg/kg of MDMA or 0.1 or 0.5 mg/kg of WIN and subsequently with both drugs. Reinstatement of the extinguished preference by priming doses was performed in the groups that showed CPP. In the second experiment, animals were conditioned with 2.5 or 5 mg/kg of MDMA and, after extinction, r…
Abnormal synchrony and effective connectivity in patients with schizophrenia and auditory hallucinations
2014
Auditory hallucinations (AH) are the most frequent positive symptoms in patients with schizophrenia. Hallucinations have been related to emotional processing disturbances, altered functional connectivity and effective connectivity deficits. Previously, we observed that, compared to healthy controls, the limbic network responses of patients with auditory hallucinations differed when the subjects were listening to emotionally charged words. We aimed to compare the synchrony patterns and effective connectivity of task-related networks between schizophrenia patients with and without AH and healthy controls. Schizophrenia patients with AH (n = 27) and without AH (n = 14) were compared with healt…
Symptom-specific amygdala hyperactivity modulates motor control network in conversion disorder
2016
Initial historical accounts as well as recent data suggest that emotion processing is dysfunctional in conversion disorder patients and that this alteration may be the pathomechanistic neurocognitive basis for symptoms in conversion disorder. However, to date evidence of direct interaction of altered negative emotion processing with motor control networks in conversion disorder is still lacking. To specifically study the neural correlates of emotion processing interacting with motor networks we used a task combining emotional and sensorimotor stimuli both separately as well as simultaneously during functional magnetic resonance imaging in a well characterized group of 13 conversion disorder…
HLA and killer cell immunoglobulin-like receptor (KIRs) genotyping in patients with acute ischemic stroke
2019
Abstract Introduction In humans, a major component of natural killer (NK) and T cell target recognition depends on the surveillance of human leukocyte antigen (HLA) class I molecules by killer immunoglobulin-like receptors (KIRs). Aims To implement the knowledge about the immunological genetic background of acute ischemic stroke susceptibility in relation to the frequency of the KIR genes and HLA alleles. Methods Subjects with acute ischemic stroke and subjects without stroke were genotyped for the presence of KIR genes and of the three major KIR ligand groups, HLA-C1, HLA-C2, and HLA-Bw4, both HLA-B and HLA-A loci. Results Between November 2013 and February 2016, consecutive patients with …