Search results for "34"

showing 10 items of 1830 documents

Historia y portentosa vida de la extatica y serafica verge S. Catherina de Sena, de la Tercera Orde de penitencia del pare y patriarcha S. Domingo ...

Grav. xil. de Sta. Caterina a port Port. amb orla tip Grav. calc. en 1 f. de làm., grav. xil. en els altres Capçaleres, Vinyetes, caplletres ornades, filets Text a 2 col. - Reclams Sign.: *2, **2, ***4, ****4, A-Z8, Aa-Ee4, Ff2

Caterina de Siena santa 1347-1380 Biografia Obres anteriors al 1800
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Vida de Sancta Catherina de Sena

Sign.: a-d8, e10, [2]. - Data completa, 11 maig, 1499 Cobles en lahor de Sancta Catherina de Sena / Narcís Vinyoles L. gòt. - 2 mides. - 31 lín. - Capll. grav. - Filigr.: mà i estel

Caterina de Siena santa 1347-1380 Biografia Obres anteriors al 1800
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Gozos a la serafica virgen Santa Catarina de Sena, del Sagrado Orden de Predicadores.

El full orlat Grav. xil. enmarcat de la santa, flanquejat per gerros amb flors El text del goig a tres col. separades per bandes

Caterina de Siena santa 1347-1380 Goigs
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Gozos a la serafica virgen Santa Catarina de Sena, del Sagrado Orden de Predicadores.

El full orlat Grav. xil. enmarcat de la santa, flanquejat per gerros amb flors El text del goig a tres col. separades per filets

Caterina de Siena santa 1347-1380 Goigs
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Gozos a la serafica virgen Santa Catarina de Sena, del Sagrado Orden de Predicadores.

El full orlat Grav. xil. enmarcat de la santa, flanquejat per gerros amb flors El text del goig a tres col. separades per filets

Caterina de Siena santa 1347-1380 Goigs
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Pues al Cielo arrebatada fuisteis por bondad Divina, sed siempre nuestra abogada, Virgen Santa Catalina ...

Imprès sense tít. Com a tít. la primera estrofa El full orlat Il·lustració de "S. Catalina de Sena", flanquejada per gerros amb flors Text del goig a tres col. separades per bandes

Caterina de Siena santa 1347-1380 Goigs lemac
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Los favores mas singulares y portentosos con que Dios sublimò ... a la ... serafica virgen Santa Catalina de Sena ... expressados en diversas laminas…

Grav. xil. en quasi totes les p. pel recte, vers en blanc Creu xil. a port Text a 1 col. Sign.: [ ]12

Caterina de Siena santa 1347-1380 Obres anteriors al 1800
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ALS-linked FUS mutations confer loss and gain of function in the nucleus by promoting excessive formation of dysfunctional paraspeckles

2019

Mutations in the FUS gene cause amyotrophic lateral sclerosis (ALS-FUS). Mutant FUS is known to confer cytoplasmic gain of function but its effects in the nucleus are less understood. FUS is an essential component of paraspeckles, subnuclear bodies assembled on a lncRNA NEAT1. Paraspeckles may play a protective role specifically in degenerating spinal motor neurons. However it is still unknown how endogenous levels of mutant FUS would affect NEAT1/paraspeckles. Using novel cell lines with the FUS gene modified by CRISPR/Cas9 and human patient fibroblasts, we found that endogenous levels of mutant FUS cause accumulation of NEAT1 isoforms and paraspeckles. However, despite only mild cytoplasm…

Cell NucleusResearchAmyotrophic Lateral SclerosisIntranuclear Inclusion BodiesNEAT1lcsh:RC346-429Cell LineLoss of Function MutationCell Line TumorFused in sarcoma (FUS)ParaspeckleHumansProtein IsoformsRNA-Binding Protein FUSRNA Long NoncodingAmyotrophic lateral sclerosis (ALS)CRISPR-Cas Systemslcsh:Neurology. Diseases of the nervous systemActa Neuropathologica Communications
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Proliferative activity and tumorigenic conversion: impact on cellular metabolism in 3-D culture

2001

Oxygen consumption, glucose, lactate, and ATP concentrations, as well as glucose and lactate turnover rates, have been studied in a three-dimensional carcinogenesis model of differently transformed rat embryo fibroblasts (spontaneously immortalized Rat1 and myc-transfected M1, and the ras-transfected, tumorigenic descendants Rat1-T1 and MR1) to determine metabolic alterations that accompany tumorigenic conversion. Various bioluminescence techniques, thymidine labeling, measurement of[Formula: see text] distributions with microelectrodes, and determination of cellular oxygen uptake rates (Q˙[Formula: see text]) have been applied. In the ras-transfected, tumorigenic spheroid types, the size d…

Cell divisionPhysiologyBiologymedicine.disease_causeDiffusionchemistry.chemical_compoundAdenosine TriphosphateOxygen ConsumptionSpheroids CellularmedicineAnimalsLactic AcidFibroblastCell Line TransformedCell growthCell BiologyTransfectionFibroblastsEmbryo MammalianRats Inbred F344In vitroRatsLactic acidOxygenCell Transformation NeoplasticGlucosemedicine.anatomical_structurechemistryBiochemistryembryonic structuresCarcinogenesisAdenosine triphosphateCell DivisionAmerican Journal of Physiology-Cell Physiology
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Rapid Differentiation of a Rare Subset of Adult Human Lin−CD34−CD38− Cells Stimulated by Multiple Growth Factors In Vitro

1999

Recently, several reports of lineage-negative (lin(-)) CD34(-) cells with in vivo hematopoietic activity have focused interest on the properties and growth factor response characteristics of these cells. We have now identified a combination of 5 growth factors that are necessary and sufficient to stimulate a marked mitogenic and differentiation response by a subset of human lin(-)CD34(-)CD38(-) cells present in normal adult human marrow and granulocyte colony-stimulating factor (G-CSF)-mobilized blood. Less than 0.1% of the cells in highly purified (including doubly sorted) lin(-)CD34(-)CD38(-) cells from these 2 sources formed colonies directly in semisolid medium or generated such cells a…

Cellular differentiationGrowth factormedicine.medical_treatmentImmunologyCD34Stem cell factorCell BiologyHematologyBiologyBiochemistryMolecular biologyHaematopoiesismedicine.anatomical_structureImmunologymedicineBone marrowStem cellInterleukin 3Blood
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