Search results for "35"
showing 10 items of 2413 documents
Lack of phenotypic additive effect of familial defective apolipoprotein B3531 in familial hypercholesterolaemia.
2020
Familial defective apolipoprotein (apo) B (FDB) and familial hypercholesterolaemia (FH) are the two common genetic conditions that cause hypercholesterolaemia. R3531C mutation of the APOB gene is a rare cause of FDB. Individuals with both FDB and FH are rare. A 51-year-old man with hypercholesterolaemia (11.4 mmol/L) and his family were studied. Low-density lipoprotein (LDL) receptor (LDLR) and APOB genes were analysed by direct sequencing. LDL of four subjects were studied in a fibroblast LDL receptor-binding displacement assay. We found a mutation of the LDLR gene (p.Y398X) in the proband and in four other family members: the p.R3531C APOB gene mutation was also found in the proband, his …
The impact of study design and diagnostic approach in a large multi-centre ADHD study: Part 2: Dimensional measures of psychopathology and intelligen…
2011
Contains fulltext : 97437.pdf (Publisher’s version ) (Open Access) BACKGROUND: The International Multi-centre ADHD Genetics (IMAGE) project with 11 participating centres from 7 European countries and Israel has collected a large behavioural and genetic database for present and future research. Behavioural data were collected from 1068 probands with ADHD and 1446 unselected siblings. The aim was to describe and analyse questionnaire data and IQ measures from all probands and siblings. In particular, to investigate the influence of age, gender, family status (proband vs. sibling), informant, and centres on sample homogeneity in psychopathological measures. METHODS: Conners' Questionnaires, St…
Soil Science Challenges in a New Era: A Transdisciplinary Overview of Relevant Topics
2020
Transdisciplinary approaches that provide holistic views are essential to properly understand soil processes and the importance of soil to society and will be crucial in the future to integrate distinct disciplines into soil studies. A myriad of challenges faces soil science at the beginning of the 2020s. The main aim of this overview is to assess past achievements and current challenges regarding soil threats such as ero-sion and soil contamination related to different United Nations sustainable development goals (SDGs) including (1) sustainable food production, (2) ensure healthy lives and reduce environmental risks (SDG3), (3) ensure water availability (SDG6), and (4) enhanced soil carbo…
An Early Beginning of Citizen Science: Adolescents Experiencing Urban Energy Usages and Air Pollution
2021
Here, we report on the process and development of high school science projects, which were inspired by a citizen science program focused on urban monitoring. We gathered and discussed two 1980s projects’ data, involving 2600 students, 80 teachers, 15 scientists and 20 stakeholders. We added recent survey data from speaking with the former participants. Our analysis revealed key findings: (1) the process of a student-driven science investigation engages students in the scientific practices; (2) it is important to bring together scientists, teachers and students, reflecting the importance of multi-dimensional learning; and (3) citizen science was born before the 1990s, when the term came into…
Are Cities Aware Enough? A Framework for Developing City Awareness to Climate Change
2020
Cities are growing and becoming more complex, and as they continue to do so, their capacity to deal with foreseen and unforeseen challenges derived from climate change has to adapt accordingly. In the last decade, an effort has been made to build city resilience and improve cities' capacity to respond to, recover from and adapt to climate change. However, certain city stakeholders' lack of proactive behavior has resulted in less effective city resilience-building strategies. In this sense, the importance of developing stakeholders&rsquo
Sustainable Development Model for the Automotive Industry
2019
The relationship between sustainability and business has become one of the central debates at the national and international level in both industrialized and emerging countries. A series of existing business models lack some critical aspects. The automotive industry strongly affects economic development, requiring rethinking business models in order to reduce their impact on the environment. An evaluation of the websites of the major automotive industry companies shows they have reported sustainability (through different methods) and present various practices in implementing organizational sustainability (OS). This paper aims to present a new business model for the automotive industry that …
Business Models Addressing Sustainability Challenges—Towards A New Research Agenda
2020
From just another buzzword a few decades ago, sustainability has become a hot topic on strategists&rsquo
Negotiation mechanisms for capacity allocation in distributed enterprises
2003
Abstract The paper proposes an agent based approach for the capacity allocation in distributed enterprises, characterized by complex and articulated organizations and by geographically distributed production capacities contended by many product families. In such a scenario the process of allocating the production capacity to the single customer order is one the major bottlenecks of the production planning activity as far as many organizational decisional levels are involved and market turbulence implies a continuous retuning of the capacity allocation plan. A high grade of reactiveness is needed. Agent based approaches and negotiation models, by decentralizing the decisional control and sim…
Exploring the opportunities and challenges of european design policy to enable innovation. The case of designscapes project
2020
Design policy for innovation and prosperity has been acknowledged and adopted globally. Existing literature on design policy usually adopts a top-down perspective to analyse the components of the design innovation system and ignores the practical needs of practitioners. Our study aims to explore potential opportunities and challenges of design policies for design-enabled innovation from a bottom-up perspective. We firstly discussed the enabling role of design in the context of design as input, output and process of innovation with emphasis on design-enabled innovation conception
Value co-creation process and measurement in 4.0 SMEs: An exploratory research in a B2B marketing innovation context
2021
The purpose of this exploratory research is to contribute to the lack of empirical research exploring techniques and protocols that can be used to measure the level of value obtained from using these technologies in the various marketing processes and in a business-to-business (B2B) context. By doing so, firms operating in fast changing dynamic environments can develop the right means to continuously adapt, integrate, reconfigure, and redeploy resources and capabilities to become more competitive and disruptive in their offerings. The phenomenon of interest is described by applying a case study qualitative approach to three 4.0 companies which use virtual reality (VR)/augmented reality (AR)…