Search results for "36"

Development and in vitro Evaluation of Antigen-Loaded Poly(amidoamine) Nanoparticles for Respiratory Epithelium Applications

2013

A poly(amidoamine) with disulfide linkages in the main chain and 4-hydroxybutyl and ω-carboxy-PEG groups (9:1 ratio) as side chains was prepared by Michael addition polymerization of cystamine bisacrylamide with 4-hydroxybutylamine and ω-carboxy-PEG-amine. To develop therapeutic protein formulations for improved delivery of antigen via the intranasal route, nanoparticles were prepared from this polymer by self-assembly with p24 or ovalbumin as the model proteins and CpG as the adjuvant. The nanoparticles incorporated the antigens and adjuvant from the feed solution with high efficiency (∼90 %) and have sizes of 112 and 169 nm, respectively, with low positive surface charge (∼+2 mV). Formula…

Faldaprevir (BI 201335), BI 207127 and ribavirin oral therapy for treatment-naive HCV genotype 1: SOUND-C1 final results

2013

Background Faldaprevir (BI 201335) and deleobuvir (BI 207127) are direct-acting antiviral agents under development for the treatment of chronic HCV infection. This article describes the final results of the Phase Ib SOUND-C1 study that evaluated the interferon-free oral combination of faldaprevir, deleobuvir and ribavirin in 32 treatment-naive patients infected with HCV genotype 1. Methods Patients were randomized to receive deleobuvir 400 mg ( n=15) or 600 mg ( n=17) three times daily plus faldaprevir 120 mg once daily and weight-based ribavirin for 4 weeks. Interferon-free therapy was followed by response-guided faldaprevir plus pegylated interferon-α2a/ribavirin to week 24 or 48. Results…

Autologous conditioned serum for chronic pain in patients with osteoarthritis: A feasibility observational study

2022

Background Autologous conditioned serum is a product of blood origin, with fragmented evidence of therapeutic properties in osteoarthritis chronic pain. This pilot observational prospective study aimed to evaluate the feasibility of a treatment with conditional autologous serum (ACS) in patients with severe chronic pain and grade I-III osteoarthritis and to describe its cytokine content. Methods We prospectively collected data on consecutive patients affected by osteoarthritis grade I to III and treated with four weekly injections of ACS at our outpatient pain service. The primary outcome was pain intensity, measured with the visual analogic scale (VAS). Additional outcomes were symptoms ev…

Aggressive Angiomyxoma: unusual pelvic mass

2016

Learning objectives Background Findings and procedure details Conclusion Personal information References

On the timing properties of SAX J1808.4-3658 during its 2015 outburst

2017

We present a timing analysis of the 2015 outburst of the accreting millisecond X-ray pulsar SAX J1808.4-3658, using non-simultaneous XMM-Newton and NuStar observations. We estimate the pulsar spin frequency and update the system orbital solution. Combining the average spin frequency from the previous observed, we confirm the long-term spin down at an average rate $\dot{\nu}_{\text{SD}}=1.5(2)\times 10^{-15}$ Hz s$^{-1}$. We also discuss possible corrections to the spin down rate accounting for mass accretion onto the compact object when the system is X-ray active. Finally, combining the updated ephemerides with those of the previous outbursts, we find a long-term orbital evolution compatibl…

Evolutionary paths of binaries with a neutron star - I. The case of SAX J1808.4 - 3658

2018

The evolutionary status of the low mass X-ray binary SAX J1808.4-3658 is simulated by following the binary evolution of its possible progenitor system through mass transfer, starting at a period of $\sim$6.6 hr. The evolution includes angular momentum losses via magnetic braking and gravitational radiation. It also takes into account the effects of illumination of the donor by both the X-ray emission and the spin down luminosity of the pulsar. The system goes through stages of mass transfer and stages during which it is detached, where only the rotationally powered pulsar irradiates the donor. We show that the pulsar irradiation is a necessary ingredient to reach SAX J1808.4-3658 orbital pe…

Abstract 2903: IMAB362, a novel first-in-class monoclonal antibody for treatment of pancreatic cancer

2014

Abstract Pancreatic ductal adenocarcinoma (PDAC), the most frequent subtype (>80%) of pancreatic cancer (PC) is characterized by a generally lethal progress within a short period of time after primary diagnosis. Despite high efforts, the treatment options are very limited and mainly of palliative nature. Therefore, we investigated whether IMAB362 might represent a potential treatment option in this patient population. IMAB362 is a highly potent and tumor-cell selective therapeutic antibody which is currently in clinical development in gastro-esophageal cancer (in phase II and IIb trials). IMAB362 is directed against the tight junction molecule CLDN18.2, a proliferation-promoting tran…

In vitro Antifungal Activity of Biopolymeric Foam Activated with Carvacrol

2020

Background: Active packaging represents a defining strategy to improve food quality and safety of the packaged foods. This study aimed to evaluate the in vitro ability of commercial biopolymeric foams, namely Mater-Bi (MB), activated with 20% of carvacrol, to develop a completely biodegradable and compostable packaging to inhibit the growth of spoilage and pathogenic yeasts.
 Methods: MB foams, with and without carvacrol, were produced by melt mixing and the foaming process was performed in a laboratory press. The antifungal activity of foams containing carvacrol was tested applying the disk diffusion method. Statistical analysis was done using XLStat software version 7.5.2 for Excel.&…

Cambios de usos del suelo durante la segunda mitad del s. XX en la comarca del Camp del Turia

2015

Revista electrónica de investigación y evaluación educativa

2006

The investigation results are presented: "An investigation or research about the most relevant variables from the student’s point of view which influence the general opinion about the teacher’s performance in the Universidad Autonoma de Occidente". The problems about the influence from the students perception in evaluating their teachers is taken on from two complementary perspectives: The first constitutes the qualitative analysis which has as a support the group interviews realized in each one of the academic programs. The second involves the quantitative analysis based on multivariate statistic tools. These perspectives allow elaborating a model to establish the grade of relevance each o…