Search results for "38"
showing 10 items of 1730 documents
A frozen analogue approach to aminopyridinylimidazoles leading to novel and promising p38 MAP kinase inhibitors.
2012
In this study we report the design, synthesis, and biological evaluation of constrained aminopyridinylimidazoles as p38α MAP kinase inhibitors. The frozen analogue approach focused on the pyridinyl unit, using purine bioisosteres as constrained structure analogues. The identification of the most potent bioisostere was followed by a further derivatization to address hydrophobic region II. In combination with C-2 modifications of the imidazole core, we were able to design highly active inhibitors on the p38α MAP kinase. The inhibitor design presented herein represents a promising and highly efficient advancement of recent stages of development in this class of p38 MAP kinase inhibitors. In co…
La religión del cuerpo-mercancía: ¿un nuevo opio del pueblo?
2018
The commercial exploitation or more precisely the total capitalist management of the human body erects this as a universal divinity. The direct consequence of this generalized corporal capitalism is the massive depoliticization of the body and, often, the reflection that is dedicated to it. In this article, we seek to reflect on the current practices of bodily modifications within the framework of the changes in the regimes of neoliberal governance in recent decades. This reflection is guided by the revision of central texts of critical theory
VRS: Applicazione di uno "score di rischio" italiano su data base nazionali.
2008
The effects of fiscal policies on the economic growth in Romania
2017
This paper intends to examine the results of fiscal policy implementation in Romania, their impact on economic growth and how fiscal policies have influenced the growth of budgetary deficits. Our objective is to highlight and explore efficient fiscal consolidation strategies that can ensure a stable economic growth through sustainable public finances. The methodology consists in analysing the information provided by national and international financial institutions, comparing it to past, proposed and assumed values, and examining the efforts and results. The conclusion we reached was that, in order to restore the sustainability of public finances, the need arises for considerable fiscal con…
A microcomputer system for controlling classical conditioning experiments
1994
A microcomputer-based laboratory system for controlling stimulus presentations and data acquisition in classical conditioning experiments is described. The system comprises an Intel 386/486-based microcomputer and a commercially obtained low-cost counter/timer board with input/output lines for stimulus timing and external device control. A simple, yet versatile custom-designed structured programming language is provided for performing an unlimited number of stimulus configurations and their sequences. In electrophysiological studies, the system can be flexibly connected to computer-controlled signal conditioning systems for the amplification and filtering of multiunit and evoked field poten…
Safety Related Behaviors and Law Adherence of Shared E-Scooter Riders in Germany
2021
Shared e-scooters, whose supply and coverage keeps increasing in many cities around the globe, are rapidly changing mobility in urban road environments. As rising injury rates have been observed alongside this new form of mobility, researchers are investigating potential factors that relate to safe/unsafe e-scooter use. In Germany, e-scooter sharing platforms were only recently permitted in the middle of 2019, and their number has increased steadily since then. The aim of this study was to assess key factors that relate to their safe use, through a direct observation of e-scooters conducted at three observation sites around Berlin. Helmet use, dual use, type of infrastructure use, and trave…
Twins among history, mith and arts
2013
Hematopoietic Stem Cell Mobilization for Gene Therapy: The Combination of G-CSF+Plerixafor in Patients with Beta-Thalassemia Major Provides High Yiel…
2015
Abstract Hematopoietic stem cell engineering is a promising therapy to cure b-thalassemia, in particular for patients who lack a suitable BM donor for allogeneic transplantation. Since the engrafted gene-corrected stem cells will not have any selective advantage over the unmodified ones, the effectiveness of the therapy in this setting largely depends on the infusion of high numbers of gene-modified cells and on the conditioning regimen. The quality of the infused cells is also crucial for the clinical outcome and the duration of the therapeutic effect. HSPCs mobilization, particularly when G-CSF and plerixafor are used in combination, has been proved to be the optimal approach to harvest a…
Agreements regarding the property relations of transnational couples and their effects under the application of the twin regulations
2021
It is a true and verifiable fact that the family institution has evolved over recent decades in Europe and throughout the world, but not uniformly or at the same time. This is because it is influenced by social and cultural connotations specific to each State. All of which are respected under EU Regulations 2016/1103 and 2016/1104. This work analyses the Twins Regulations, that gives the couples the possibility of choosing the jurisdiction (art. 7) and applicable legal system underpinning the property consequences of the marriage and registered partnerships (art. 22.1). However, we try to show you these rules absolute freedom of choice is not granted to the parties, because this freedom is …