Search results for "38"
showing 10 items of 1730 documents
Las agencias de calificación y la deuda pública en la Comunidad Valenciana
2020
Resumen El objetivo de esta investigación es analizar la influencia que han tenido los mayores niveles de endeudamiento público sobre los ratings emitidos por las agencias de calificación para la Comunidad Valenciana. La acumulación de déficits junto con el estallido de la burbuja inmobiliaria terminó por afectar de manera negativa a la contabilidad pública. Asimismo, los recursos transferidos a través del sistema de financiación tampoco ayudaron a revertir la insuficiencia de ingresos para la administración valenciana. Las restricciones presupuestarias fueron reflejadas de inmediato por las agencias de calificación a través de una reducción en sus ratings, generando dificultades para obten…
Artificial intelligence in the diagnosis of pediatric allergic diseases.
2020
Abstract: Artificial intelligence (AI) is a field of data science pertaining to advanced computing machines capable of learning from data and interacting with the human world. Early diagnosis and diagnostics, self-care, prevention and wellness, clinical decision support, care delivery, and chronic care management have been identified within the healthcare areas that could benefit from introducing AI. In pediatric allergy research, the recent developments in AI approach provided new perspectives for characterizing the heterogeneity of allergic diseases among patients. Moreover, the increasing use of electronic health records and personal healthcare records highlighted the relevance of AI in …
Concubinage et faute dans la rupture
2006
International audience
Los beneficios del mar: negocios e inversiones económicas de la oficialidad naval en el siglo XVIII
2019
Throughout the eighteenth century, the Spanish navy was extensively reformed and enhanced as a consequence of the new model of Monarchy that the Bourbons introduced. Among the measures adopted, it is remarkable the erection of the naval officers corps according to the needs and obligations that maritime war had in this century. This group becomes the paradigm of the new professionalization and new training approach, and its members had great relevance due to its great mobility around the empire and the power of the naval institution. This means that a part of the naval officers were placed in privileged positions and at the intersection of diverse political, social and economic networks. Th…
Entrepreneurship – Some General Knowledge
2013
The aim of this article is to provide some general information about entrepreneurship and some insights on the early theories about it. A brief overview of the main entrepreneurship measurement programme will provide some facts about the evolution of the entrepreneurial activity in Romania in the last few years.
Analysis of the Economic Research Context after the Outbreak of the Economic Crisis of 2007-2009
2015
In this paper it, we have conducted a factor analysis which implied determining the international research directions that have characterized the period following the outbreak of the crisis in 2007 and 2008-2011. In this research, we used secondary data that were extracted from 342 articles, which were based on 665 individual researches. Following this research, we have identified three main research in the macroeconomic areas which explained 56% of all the analyzed research. Also, the results showed the trends in macroeconomic research after the start of the crisis in 2007.
Hunger and sustainability
2019
This paper examines the problem of world hunger and discusses potential solutions to it. It reflects on the debate about whether transgenic foods should be used, which is more of a social controversy than a scientific one. Sustainability is considered a key driver for innovation that can be used as a basis for assessing the problem of hunger in the world, and the question is inseparable from its ethical aspects. Given that economic growth does not directly equate to human development, this paper states that it is necessary to address the problem of poverty and hunger from the capacity development framework according to human rights. Poverty causes disability by limiting human development; i…
CD14+CD16+ Monocyte Binding to Myeloma Cells Is Required for Daratumumab Dependent Killing in Multiple Myeloma Patients
2018
Abstract Recently, the introduction of anti-CD38 monoclonal antibody, Daratumumab (DARA), in multiple myeloma (MM) therapy has improved the response rate of relapsed MM patients. However only a fraction of the DARA-treated patients respond, thus further studies on DARA mechanisms of action are needed. Because the antibody dependent cellular phagocytosis (ADCP) mediated by monocyte, is one of the mechanisms through DARA exerts its anti-MM activity, an ex-vivo approach was established in order to investigate which mechanisms or patient's immunological characteristics could influence DARA-mediated killing of MM cells. Bone marrow mononuclear cells (BM-MNCs) obtained from 25 MM patients (12 new…
CD49d Expression Identifies a Chronic Lymphocytic Leukemia (CLL) Subset with High Levels of Circulating CD34 +Cells Co-Expressing Endothelial Cell Ma…
2009
Abstract Abstract 2329 Poster Board II-306 Introduction: In chronic lymphocytic leukemia (CLL), CD49d, often in association with CD38, has been shown to mark a disease subset with poor prognosis. Functionally, both molecules act as counter-receptors for surface structures (i.e. VCAM-1/CD106 and CD31) usually expressed by the endothelial/stromal component of tumor micro-environment. We have recently identified a micro-environmental circuitry which involves CD38 triggering, and eventually determines an enrichment of the VCAM-1/CD106-expressing endothelial component detected in the context of CLL infiltrates found in bone marrow biopsies. Data was also provided that CD49d/VCAM-1 interactions a…