Search results for "38"
showing 10 items of 1730 documents
Contribution of recently measured nuclear data to reactor antineutrino energy spectra predictions
2013
This paper attempts to summarize the actual problematic of reactor antineutrino energy spectra in the frame of fundamental and applied neutrino physics. Nuclear physics is an important ingredient of reactor antineutrino experiments. These experiments are motivated by neutrino oscillations, i.e. the measure of the θ 13 mixing angle. In 2011, after a new computation of the reactor antineutrino energy spectra, based on the conversion of integral data of the beta spectra from 235 U, and 239;241 Pu, a deficit of reactor antineutrinos measured by short baseline experiments was pointed out. This is called the “reactor anomaly”, a new puzzle in the neutrino physics area. Since then, numerous new ex…
Lifecycle of Polycystic Ovary Syndrome (PCOS): From In Utero to Menopause
2013
Context: Polycystic ovary syndrome (PCOS) is diagnosed during the reproductive years when women present with 2 of 3 of the following criteria: 1) irregular menstrual cycles or anovulation, 2) hyperandrogenism, and 3) PCO morphology. However, there is evidence that PCOS can be identified from early infancy to puberty based on predisposing environmental influences. There is also increasing information about the PCOS phenotype after menopause. The goal of this review is to summarize current knowledge about the appearance of PCOS at different life stages and the influence of reproductive maturation and senescence on the PCOS phenotype. Evidence: PubMed, the bibliography from the Evidence-Based …
Nuovi markers sierologici in corso di Malattia Infiammatoria Cronica Intestinale [New serological markers in IBD diagnosis]
2011
IBD diagnosis, in spite of clinically suspected form, lies on upper and lower endoscopy. Nevertheless endoscopic investigation is an invasive diagnostic tool especially in pediatric age. For this reason pediatricians are looking for mini invasive diagnostic algorithm in order to avoid unnecessary endoscopy. Up to date, while fecal calprotectin is a well established and confirmed intestinal inflammatory marker, on the other hand, new perspectives are opening on serological markers helpful in suspected diagnosis of IBD
Differential Effects of Fluvoxamine and Other Antidepressants on the Biotransformation of Melatonin
2001
Melatonin, the predominant product of the pineal gland, is involved in the maintenance of diurnal rhythms. Nocturnal blood concentrations of melatonin have been shown to be enhanced by fluvoxamine, but not by other serotonin reuptake inhibitors. Because fluvoxamine is an inhibitor of several cytochrome P450 (CYP) enzymes, the authors studied the biotransformation of melatonin and the effects of fluvoxamine on the metabolism of melatonin in vitro using human liver microsomes and recombinant human CYP isoenzymes. Melatonin was found to be almost exclusively metabolized by CYP1A2 to 6-hydroxymelatonin and N-acetylserotonin with a minimal contribution of CYP2C19. Both reactions were potently in…
Muscle Histopathological Abnormalities in a Patient With a CCT5 Mutation Predicted to Affect the Apical Domain of the Chaperonin Subunit.
2022
Recognition of diseases associated with mutations of the chaperone system genes, e.g., chaperonopathies, is on the rise. Hereditary and clinical aspects are established, but the impact of the mutation on the chaperone molecule and the mechanisms underpinning the tissue abnormalities are not. Here, histological features of skeletal muscle from a patient with a severe, early onset, distal motor neuropathy, carrying a mutation on the CCT5 subunit (MUT) were examined in comparison with normal muscle (CTR). The MUT muscle was considerably modified; atrophy of fibers and disruption of the tissue architecture were prominent, with many fibers in apoptosis. CCT5 was diversely present in the sarcolem…
Genetic polymorphism of the bitter taste TAS2R38 gene in central Sicily
2007
Bitter taste genetics and food preference in italian population
2010
Objective: To investigate the possible role of the polymorphic bitter taste gene, TAS2R38, known to be involved in the perception of the bitter synthetic chemical phenylthiocarbamide (PTC), in influencing food preference and body mass index(BMI). Methods: up to now more than 1500 university students (17-25 years old) at Catania, Cosenza, Rome, Palermo, Pisa, Parma, Chieti, Trento University have been enrolled in the study. DNA was extracted from saliva, and genotyped by TaqMan assay for the most frequent polymorphism (PAV/AVI) of TAS2R38 gene. A possible association between genotype and food preference was assessed by administering a detailed questionnaire for food preferences and life styl…
La privatizzazione dell'Università. Il modello delle fondazioni. Un caso di perniciosa penetrazione del diritto privato nel diritto pubblico
2014
Lo studio prende mosse dalla ricostruzione dell'ordinamento universitario, per poi concentrarsi sul tema delle fondazioni universitarie. Dando conto tanto di quelle istituite in forza della legge 388/2000 (e del d.P.R. 254/2001), quanto di quelle di cui al decreto-legge 112/2008 convertito in legge 133/2008 (c.d. riforma Gelmini), l'Autore ne pone in luce aspetti positivi e dubbi di incostituzionalità, giungendo a proporre nuove forme di partenariato pubblico-privato.
Esercizio di un diritto e coercizione alle dimissioni: un caso particolare di violenza
2017
La decisione commentata applica l’art. 1438 c.c. in un caso di dimissione del lavoratore. Pur richiamandosi all’interpretazione maggioritaria con riguardo all’ingiustizia del vantaggio richiamata dall’art. 1438, essa si presta ad alcuni rilievi critici a causa delle peculiarita` del caso deciso: oggetto della minaccia era infatti l’esecuzione da parte del datore di lavoro (una banca) nei confronti di un soggetto completamente estraneo al rapporto di lavoro (la figlia del lavoratore).
Istruttoria tecnico-scientifica nel giudizio a quo e giudizio di legittimità costituzionale: il caso dell’obbligo vaccinale nella decretazione d’urge…
2022
Muovendo dall’ordinanza n. 38 del 2022 del Consiglio di giustizia amministrativa per la Regione siciliana (CGARS), il contributo si sofferma a) sull’estensione per analogia degli obblighi vaccinali; b) su oscurità ed incoerenze della disciplina sugli obblighi vaccinali in tema di accesso alle strutture socio-sanitarie. Il contributo si incentra poi sull'istruttoria tecnico-scientifica e la motivazione sulla non manifesta infondatezza delle questioni di legittimità costituzionale aventi ad oggetto la disciplina sull'obbligo vaccinale e sugli aspetti problematici dell'ordinanza di rimessione del CGARS.