Search results for "3a"
showing 10 items of 351 documents
MiR-29b-1 expression impaired Cancer Stem-Like properties of human osteosarcoma 3AB-OS cells in vitro.
2013
Osteosarcoma (OS) is the most common type of bone cancer, with a peak incidence in the early childhood. Emerging evidence suggests that treatments targeting cancer stem cells (CSCs) within a tumor can halt cancer and improve patient survival. Although microRNAs are frequently dysregulated in human cancers, if they influence OS malignancy and whether or not targeting CSC-associated microRNAs inhibit OS progression remain unclear. Recently (1), we described a predictive network for two downregulated miRNA family (let-7/98 and miR-29a,b,c) and their upregulated anticorrelated mRNAs. Here, we investigated in vitro the role of miR-29b-1 in regulating cell proliferation, clonogenic growth and che…
MicroRNA-29b-1 is involved in self-renewal and fate decisions of human osteosarcoma 3AB-OS cancer stem cells
2014
Emerging evidence suggests that treatments targeting cancer stem cells (CSCs) within a tumor can halt cancer and improve patient survival. Moreover, identification of CSC-related MicroRNAs (miRNAs) would provide information for a better understanding of CSCs. miR-29 family is a class of miRNAs aberrantly expressed in multiple cancers. They are frequently down-regulated in osteosarcoma (OS), the most common form of childhood cancer with a potent metastasizing potential. 3AB-OS CSC, a human pluripotent CSC line by us produced from the human osteosarcoma MG63 cells (1) is a useful model to study CSC origin and roles (2). Previously, we have shown that in 3AB-OS CSCs miR-29b is potently down-re…
Reduction of nevirapine-driven HIV mutations by carbamazepine is modulated by CYP3A activity
2014
Item does not contain fulltext OBJECTIVES: The reduction in mother-to-child transmission of HIV-1 by single-dose nevirapine given at birth onset is achieved at the expense of de novo HIV-1 resistance mutations. In the VITA1 study, single-dose carbamazepine accelerated nevirapine elimination, but the accompanying trend towards fewer de novo HIV-1 mutations was statistically non-significant. METHODS: We investigated if the effect of carbamazepine was confounded by the individual variability in nevirapine metabolism and transport. RESULTS: Nine of 34 (26%) single-dose nevirapine-treated women had one or more nevirapine-associated resistance mutations, compared with 3 of 34 (9%) in the single-d…
Inducing properties of rifampicin and rifabutin for selected enzyme activities of the cytochrome P-450 and UDP-glucuronosyltransferase superfamilies …
1996
Important species differences have been reported concerning the induction properties of rifampicin towards enzymes of the P-450 superfamily. Mice, rabbits and humans are far more responsive than rats and guinea pigs. In the present study a strong induction of cytochrome P-450 3A-dependent enzyme activities was observed in female rat liver microsomes after high dose treatment (> or = 250 mg/kg/day for 9 days) with rifampicin, resulting in an up to 30-fold enhanced hydroxylation rate of testosterone in the 2 beta-, 6 beta- and 15 beta-position in vitro. Other cytochrome P-450 isozyme-selective reactions were not, or only marginally, affected. A steep increase in cytochrome P-450 3A activity o…
On base loci of higher fundamental forms of toric varieties
2019
We study the base locus of the higher fundamental forms of a projective toric variety $X$ at a general point. More precisely we consider the closure $X$ of the image of a map $({\mathbb C}^*)^k\to {\mathbb P}^n$, sending $t$ to the vector of Laurent monomials with exponents $p_0,\dots,p_n\in {\mathbb Z}^k$. We prove that the $m$-th fundamental form of such an $X$ at a general point has non empty base locus if and only if the points $p_i$ lie on a suitable degree-$m$ affine hypersurface. We then restrict to the case in which the points $p_i$ are all the lattice points of a lattice polytope and we give some applications of the above result. In particular we provide a classification for the se…
Ligand Diversity of Human and Chimpanzee CYP3A4: Activation of Human CYP3A4 by Lithocholic Acid Results from Positive SelectionS⃞
2009
For currently unknown reasons, the evolution of CYP3A4 underwent acceleration in the human lineage after the split from chimpanzee. We investigated the significance of this event by comparing Escherichia coli-expressed CYP3A4 from humans, chimpanzee, and their most recent common ancestor. The expression level of chimpanzee CYP3A4 was ∼50% of the human CYP3A4, whereas ancestral CYP3A4 did not express in E. coli. Steady-state kinetic analysis with 7-benzyloxyquinoline, 7-benzyloxy-4-(trifluoromethyl)coumarin (7-BFC), and testosterone showed no significant differences between human and chimpanzee CYP3A4. Upon addition of α-naphthoflavone (25 μM), human CYP3A4 showed a slightly decreased substr…
Informal musical activities are linked to auditory discrimination and attention in 2-3-year-old children: an event-related potential study
2012
The relation between informal musical activities at home and electrophysiological indices of neural auditory change detection was investigated in 2-3-year-old children. Auditory event-related potentials were recorded in a multi-feature paradigm that included frequency, duration, intensity, direction, gap deviants and attention-catching novel sounds. Correlations were calculated between these responses and the amount of musical activity at home (i.e. musical play by the child and parental singing) reported by the parents. A higher overall amount of informal musical activity was associated with larger P3as elicited by the gap and duration deviants, and smaller late discriminative negativity r…
CCDC 219569: Experimental Crystal Structure Determination
2005
Related Article: A.Valkonen, M.Lahtinen, E.Virtanen, S.Kaikkonen, E.Kolehmainen|2004|Biosens.Bioelectron.|20|1233|doi:10.1016/j.bios.2004.06.029
CCDC 647953: Experimental Crystal Structure Determination
2017
Related Article: A.Valkonen, E.Kolehmainen, M.Lahtinen, E.Sievanen, V.Noponen, M.Tolonen, R.Kauppinen|2007|Molecules|12|2161|doi:10.3390/12092161
Zvaigžņotā Debess: 2016, Vasara (232)
2016
Contents: “ZVAIGŽŅOTĀ DEBESS” FORTY YEARS AGO: A.Balklavs. New Studies and Conclusions on Nucleus of the Galaxy (abridged) ; U.Dzērvītis. Discussion on Planetary System of Barnard’s Star Continues (abridged) ; M.Eliāss. Meeting of Solar Radio Radiation Section (abridged) ; DEVELOPMENTS in SCIENCE: O.Dumbrājs. Neutrino Oscillations: from the Outset to the Nobel Prize ; R.Misa. Conversation with Andris Ambainis on Quantum Computing Science ; DISCOVERIES: F.Gahbauer. First Direct Detection of Gravitational Waves ; I.Pundure. ATLASGAL Survey of Milky Way Completed ; SPACE RESEARCH and EXPLORATION: J.Jaunbergs. The Story of Pluto’s Satellites ; K.Schwartz. Conducting Ice and Magnetic Field of Ur…