Search results for "3a"

Red wine extract prevents neuronal apoptosis in vitro and reduces mortality of transgenic mice.

2007

In this work, we have investigated the effects of nutritional antioxidants as antidegenerative agents on glutamate-induced apoptosis in primary cultures of cerebellar granule neurons (CGNs). Glutamate-induced apoptosis is also associated with intracellular [Ca(2+)]i overload, generation of reactive oxygen species (ROS), depression of cell energy metabolism, cytochrome c release, and increase in caspase-3 activity. Pretreatment (3 h) with red wine extract (5 microg/mL) and ascorbic acid (30 microM) blocks glutamate-induced apoptosis in CGNs. In vivo experiments carried out on transgenic mice expressing the human mutated Cu, Zn superoxide dismutase (SOD1) G93A (mSOD1(G93A)) show that mice fed…

Cellule staminali pluripotenti embrionali cancerose, loro preparazione e loro uso.

2008

Karyotypic Complexity and Chromosomal Aberrations In Human Embryonic Cancer Stem Cells 3AB-OS.

2009

The signature of longevity in Sicily

2019

Ageing is a natural and physiological condition that is the result of compromised stress response, homeostatic imbalance and increased risk of developing diseases. However, if aging with good health and functions (successful ageing) and aging with disease and disability (unsuccessful ageing) depends on a combination of “positive features”, including genetic, epigenetic and phenotypic characteristics in combination with favourable environment, economic status and social involvement. In our study, we summarize some key points for the identification of a longevity signature, with a particular focus on long-living Sicilian individuals and centenarians. Analysing three different Sicilian cohorts…

Butyrophilin 3A1 presents phosphoantigens to human γδ T cells: the fourth model of antigen presentation in the immune system.

2013

Butyrophilin 3A1 presents phosphoantigens to human γδ T cells: the fourth model of antigen presentation in the immune system

How Important Are Genes to Achieve Longevity?

2022

Several studies on the genetics of longevity have been reviewed in this paper. The results show that, despite efforts and new technologies, only two genes, APOE and FOXO3A, involved in the protection of cardiovascular diseases, have been shown to be associated with longevity in nearly all studies. This happens because the genetic determinants of longevity are dynamic and depend on the environmental history of a given population. In fact, population-specific genes are thought to play a greater role in the attainment of longevity than those shared between different populations. Hence, it is not surprising that GWAS replicated associations of common variants with longevity have been few, if an…

THE EFFECT OF CYP3A5 AND ABCB1 SINGLE NUCLEOTIDE POLYMORPHISMS ON TACROLIMUS DOSE REQUIREMENTS IN CAUCASIAN LIVER TRANSPLANT PATIENTS

2008

Loss of the Sin3A/Rpd3 Histone De-Acetylase Complex Causes Telomeric Fusions

2008

Test module filtrations for unit $F$-modules

2015

We extend the notion of test module filtration introduced by Blickle for Cartier modules. We then show that this naturally defines a filtration on unit $F$-modules and prove that this filtration coincides with the notion of $V$-filtration introduced by Stadnik in the cases where he proved existence of his filtration. We also show that these filtrations do not coincide in general. Moreover, we show that for a smooth morphism $f: X \to Y$ test modules are preserved under $f^!$. We also give examples to show that this is not the case if $f$ is finite flat and tamely ramified along a smooth divisor.

CCDC 607535: Experimental Crystal Structure Determination

2007

Related Article: A.Hoffmann-Roder, E.Schweizer, J.Egger, P.Seiler, U.Obst-Sander, B.Wagner, M.Kansy, D.W.Banner, F.Diederich|2006|ChemMedChem|1|1205|doi:10.1002/cmdc.200600124