Search results for "3alpha"

showing 10 items of 33 documents

International genome-wide meta-analysis identifies new primary biliary cirrhosis risk loci and targetable pathogenic pathways

2015

Primary biliary cirrhosis (PBC) is a classical autoimmune liver disease for which effective immunomodulatory therapy is lacking. Here we perform meta-analyses of discovery data sets from genome-wide association studies of European subjects (n=2,764 cases and 10,475 controls) followed by validation genotyping in an independent cohort (n=3,716 cases and 4,261 controls). We discover and validate six previously unknown risk loci for PBC (Pcombined<5 × 10−8) and used pathway analysis to identify JAK-STAT/IL12/IL27 signalling and cytokine–cytokine pathways, for which relevant therapies exist.

Liver CirrhosisGenetics and Molecular Biology (all)pathogenesirisk assessment EMTREE medical terms: Articlegenetic associationgenotypeEMTREE drug terms: chemokine receptor CCR6genetic riskBiochemistrymeta-analysiprimary biliary cirrhosichemokine receptor CCR6 [EMTREE drug terms]single nucleotide polymorphismgenetic variabilityArticle [risk assessment EMTREE medical terms]Liver Cirrhosis BiliarypathogenesisBiliaryChemistry (all)STAT protein GEOBASE Subject Index: disease treatmentcohort analysisgenome wide meta analysis PBCsignal transductiongene locuscohort analysiCBPArticle*Physics and Astronomy (all)macrophage inflammatory protein 3alphaHumanscontrolled studyhumaninterleukin 27genomeBiochemistry Genetics and Molecular Biology (all)meta analysiinterleukin 12p40EMTREE drug terms: chemokine receptor CCR6; interleukin 12; interleukin 12p40; interleukin 27; Janus kinase; macrophage inflammatory protein 3alpha; STAT protein GEOBASE Subject Index: disease treatment; genome; meta-analysis; pathogen; risk assessment EMTREE medical terms: Article; cohort analysis; controlled study; gene locus; genetic association; genetic predisposition; genetic risk; genetic variability; genotype; human; major clinical study; meta analysis; pathogenesis; primary biliary cirrhosis; signal transduction; single nucleotide polymorphismmajor clinical studyprimary biliary cirrhosismeta-analysisdisease treatment [STAT protein GEOBASE Subject Index]Biochemistry Genetics and Molecular Biology (all); Chemistry (all); Physics and Astronomy (all)Humans; Liver Cirrhosis; Biliary; Genome-Wide Association Study; Biochemistry; Genetics and Molecular Biology (all); Chemistry (all); Physics and Astronomy (all)gene locuinterleukin 12genetic predispositionJanus kinasepathogenmeta analysisHumans; Liver Cirrhosis Biliary; Genome-Wide Association Study; Biochemistry Genetics and Molecular Biology (all); Chemistry (all); Physics and Astronomy (all)Genome-Wide Association Study
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CCDC 652752: Experimental Crystal Structure Determination

2009

Related Article: A.Valkonen, M.Lahtinen, J.Tamminen, E.Kolehmainen|2008|J.Mol.Struct.|886|197|doi:10.1016/j.molstruc.2007.11.018

Methyl 3alpha-(26-dichlorobenzoyloxy)-7alpha12alpha-dihydroxy-5beta-cholan-24-oateSpace GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 219569: Experimental Crystal Structure Determination

2005

Related Article: A.Valkonen, M.Lahtinen, E.Virtanen, S.Kaikkonen, E.Kolehmainen|2004|Biosens.Bioelectron.|20|1233|doi:10.1016/j.bios.2004.06.029

N-(3-Hydroxypropyl)-3alpha12alpha-dihydroxy-5beta-cholan-24-amideSpace GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 647953: Experimental Crystal Structure Determination

2017

Related Article: A.Valkonen, E.Kolehmainen, M.Lahtinen, E.Sievanen, V.Noponen, M.Tolonen, R.Kauppinen|2007|Molecules|12|2161|doi:10.3390/12092161

N-(3-hydroxypropyl) 3alpha12alpha-dihydroxy-5beta-cholan-24-amide monohydrateSpace GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 866801: Experimental Crystal Structure Determination

2012

Related Article: A.V.B.Djoumessi, L.P.Sandjo, J.C.Liermann, D.Schollmeyer, V.Kuete, V.Rincheval, A.M.Berhanu, S.O.Yeboah, P.Wafo, B.T.Ngadjui, T.Opatz|2012|Tetrahedron|68|4621|doi:10.1016/j.tet.2012.04.027

Space GroupCrystallography1327-Cyclo-3alpha19alpha-dihydroxyolean-11-ene-2428-dioic acid methanol solvateCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 1547602: Experimental Crystal Structure Determination

2017

Related Article: Agris Be¯rzinš, Aija Trimdale, Artis Kons, Dace Zvanina|2017|Cryst.Growth Des.|17|5712|doi:10.1021/acs.cgd.7b00657

Space GroupCrystallography3alpha7alpha12alpha-trihydroxy-5beta-cholan-24-oic acid methyl ester hemihydrateCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 736983: Experimental Crystal Structure Determination

2010

Related Article: Nonappa, M.Lahtinen, S.Ikonen, E.Kolehmainen, R.Kauppinen|2009|Cryst.Growth Des.|9|4710|doi:10.1021/cg9005828

Space GroupCrystallography3alpha7beta-dihydroxy-5beta-cholan-24-oic acidCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 1547604: Experimental Crystal Structure Determination

2017

Related Article: Agris Be¯rzinš, Aija Trimdale, Artis Kons, Dace Zvanina|2017|Cryst.Growth Des.|17|5712|doi:10.1021/acs.cgd.7b00657

Space GroupCrystallographyCrystal System3alpha7alpha12alpha-trihydroxy-5beta-cholan-24-oic acid methyl esterCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 1547606: Experimental Crystal Structure Determination

2017

Related Article: Agris Be¯rzinš, Aija Trimdale, Artis Kons, Dace Zvanina|2017|Cryst.Growth Des.|17|5712|doi:10.1021/acs.cgd.7b00657

Space GroupCrystallographyCrystal System3alpha7alpha12alpha-trihydroxy-5beta-cholan-24-oic acid methyl esterCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 1547598: Experimental Crystal Structure Determination

2017

Related Article: Agris Be¯rzinš, Aija Trimdale, Artis Kons, Dace Zvanina|2017|Cryst.Growth Des.|17|5712|doi:10.1021/acs.cgd.7b00657

Space GroupCrystallographyCrystal System3alpha7alpha12alpha-trihydroxy-5beta-cholan-24-oic acid methyl esterCrystal StructureCell ParametersExperimental 3D Coordinates
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