Search results for "3b"
showing 10 items of 143 documents
CCDC 1047646: Experimental Crystal Structure Determination
2017
Related Article: Michael Mirion, Lars Andernach, Caroline Stobe, Joaquin Barjau, Dieter Schollmeyer, Till Opatz, Arne Lützen, Siegfried R. Waldvogel|2015|Eur.J.Org.Chem.|2015|4876|doi:10.1002/ejoc.201500600
CCDC 1484252: Experimental Crystal Structure Determination
2016
Related Article: Stefan Pusch, Dieter Schollmeyer, Till Opatz|2016|Org.Lett.|18|3043|doi:10.1021/acs.orglett.6b01449
CCDC 1484251: Experimental Crystal Structure Determination
2016
Related Article: Stefan Pusch, Dieter Schollmeyer, Till Opatz|2016|Org.Lett.|18|3043|doi:10.1021/acs.orglett.6b01449
CCDC 652753: Experimental Crystal Structure Determination
2009
Related Article: A.Valkonen, M.Lahtinen, J.Tamminen, E.Kolehmainen|2008|J.Mol.Struct.|886|197|doi:10.1016/j.molstruc.2007.11.018
CCDC 652754: Experimental Crystal Structure Determination
2009
Related Article: A.Valkonen, M.Lahtinen, J.Tamminen, E.Kolehmainen|2008|J.Mol.Struct.|886|197|doi:10.1016/j.molstruc.2007.11.018
Investigating the Molecular Mechanism of H3B-8800: A Splicing Modulator Inducing Preferential Lethality in Spliceosome-Mutant Cancers.
2021
The SF3B1 protein, part of the SF3b complex, recognizes the intron branch point sequence of precursor messenger RNA (pre-mRNA), thus contributing to splicing fidelity. SF3B1 is frequently mutated in cancer and is the target of distinct families of splicing modulators (SMs). Among these, H3B-8800 is of particular interest, as it induces preferential lethality in cancer cells bearing the frequent and highly pathogenic K700E SF3B1 mutation. Despite the potential of H3B-8800 to treat myeloid leukemia and other cancer types hallmarked by SF3B1 mutations, the molecular mechanism underlying its preferential lethality towards spliceosome-mutant cancer cells remains elusive. Here, microsecond-long a…
Synthesis of new derivatives of Nortopsentin with potential inhibitory activity against GSK-3b
Suppressive effects of C3b on monocyte-dependent T cell proliferation.
1987
The effect of C3b treatment of human monocytes on secondary antigen-dependent T cell response was studied. When antigen-specific T cell blasts were cultivated together with C3b-treated monocytes the proliferative response was inhibited in a dose-dependent fashion. This suppressive effect was specific for C3b because heat-inactivated C3b or buffer alone had no influence on T cell proliferation. In part, this suppressive effect is mediated through a C3b-induced decreased expression of class II antigens on the surface of treated monocytes, but another suppressive mechanism exists because the C3b pretreatment of monocytes also led to an inhibition of the proliferative response in a class II ant…
Underlying Simple Graphs
2019
Summary In this article the notion of the underlying simple graph of a graph (as defined in [8]) is formalized in the Mizar system [5], along with some convenient variants. The property of a graph to be without decorators (as introduced in [7]) is formalized as well to serve as the base of graph enumerations in the future.
Caracterización molecular de la anemia refractaria con sideroblastos en anillo mediante un panel de secuenciación de segunda generación
2019
Los síndromes mielodisplásicos (SMD) son un grupo heterogéneo de neoplasias hematológicas que presentan citopenias, mielodisplasia, hematopoyesis ineficaz y un riesgo variable de transformación a leucemia mieloide aguda (t-LMA). Los SMD con sideroblastos en anillo (SMD-SA) constituyen aproximadamente el 10-12% de todos los SMD y en médula ósea muestran SA, eritroblastos con depósitos anormales de ferritina, en porcentaje igual o superior al 5%. El objetivo terapéutico en los SMD-SA es mejorar las citopenias y su sintomatología, en especial el síndrome anémico. La administración de eritropoyetina y el soporte transfusional con concentrados de hematíes son las opciones terpéuticas de primera …