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Pyrido[2’,3’:4,5]pyrrolo[2,1-d][1,2,3,5]tetrazine-4(3H)-ones, a new class of temozolomide heteroanalogues

2009

Twelve derivatives of new ring system pyrido[2’,3’:4,5]pyrrolo[2,1-d][1,2,3,5]tetrazine were prepared in good yields by reaction of 2-diazo-3-ethoxycarbonyl-pyrrolo[3,2-b]pyridine with alkyl- or aryl-isocyanates. Nine derivatives, screened by the National Cancer Institute (Bethesda, MD) for the in vitro one dose primary anticancer assay against a panel of about 60 human tumor cell lines, showed no significant activity.

3Stereochemistry21-d][1Temozolomide Mitozolomide; pyrrolo[2; 1-d][1; 2; 3; 5]tetrazinones; Antitumor activity; pyrido[2’; 3’:4; 5]pyrrolo[2; 1-d][1; 2; 3; 5]tetrazinesTemozolomide MitozolomideRing (chemistry)Medicinal chemistryD-1Tetrazinechemistry.chemical_compoundpyrido[2’PyridineAlkylchemistry.chemical_classification5]tetrazinonesOrganic Chemistrypyrrolo[23’:4Antitumor activity pyrido[2’3’:45]pyrrolo[21-d][1235]tetrazinesSettore CHIM/08 - Chimica Farmaceuticachemistry5]pyrrolo[2Microwave irradiationTemozolomide Mitozolomide pyrrolo[21-d][1235]tetrazinoneAntitumor activity5]tetrazinesArkivoc
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