Search results for "4 D"
showing 10 items of 15011 documents
La représentation sociale de l'hygiène chez les professionnels de santé : Intérêt du recueil par entretien et de l'analyse discursive des opérateurs …
2009
This study deals with professional representations. The goal is to show the representation of hygiene by health care workers: Nurses (N) and Health Care Aides (HCA). Method follows the BSC (Bases Cognitive Schemes) procedure, explicative interviews substitute to the evaluation task. An analysis of associative words points out that for HCA hygiene is associated with acts linked with corporal hygiene and with two synonymous: no trace, no germ Discussion underlines the interest of this method for professional representations studies and nosocomial infections strength.
Serum omega-3 fatty acids are not associated with age-related macular degeneration
2012
Revue non indexée dans le JCR.; International audience; Evaluation of: Kabasawa S, Mori K, Horie-Inoue K et al. Associations of cigarette smoking but. not serum fatty acids with age-related macular degeneration in a Japanese population. Ophthalmology 118(6), 1082–1088 (2011). Age-related macular degeneration (AMD) is the leading cause of visual impairment in the elderly. in developed countries. Risk factors for AMD are classified into endogenous nonmodifiable. factors, including genetics and environmental factors such as smoking and dietary habits. Both. epidemiological and experimental studies suggest that dietary omega-3 long-chain fatty acids. would participate to prevent from the develo…
FUNCIONAMIENTO EJECUTIVO TEMPRANO EN NIÑOS CON DIFICULTADES MATEMÁTICAS PERSISTENTES
2016
El objetivo del presente estudio consistió en examinar las diferencias en las funciones ejecutivas de inhibición y memoria de trabajo (MT) evaluadas en Educación Infantil entre sujetos con dificultades persistentes en el área de matemáticas en 2º de Educación Primaria y niños con un rendimiento adecuado. La muestra final del estudio estuvo conformada por 180 niños (inicialmente compuesta por 209 preescolares), de los cuales un 6.6% presentaron dificultades matemáticas persistentes (n = 12) y el 45.5% mostraron un rendimiento adecuado en ambas mediciones (n = 82). En Educación Infantil, se administraron seis tareas neuropsicológicas relacionadas con las funciones ejecutivas de inhibición, MT…
Inflammatory cytokines shape a changing DNA methylome in monocytes mirroring disease activity in rheumatoid arthritis
2019
Objective: Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease that mainly targets joints. Monocytes and macrophages are critical in RA pathogenesis and contribute to inflammatory lesions. These extremely plastic cells respond to extracellular signals which cause epigenomic changes that define their pathogenic phenotype. Here, we interrogated how DNA methylation alterations in RA monocytes are determined by extracellular signals. Methods: High-throughput DNA methylation analyses of patients with RA and controls and in vitro cytokine stimulation were used to investigate the underlying mechanisms behind DNA methylation alterations in RA as well as their relationship with clinic…
The Clinical Value of Autoantibodies in Rheumatoid Arthritis
2018
Rheumatoid arthritis (RA) is a highly heterogeneous syndrome in terms of clinical presentation, progression, and response to therapy. In such a complicated context, the identification of disease-related biomarkers would be undoubtedly helpful in assisting tailored approaches for every patient. Despite remarkable efforts, however, progress in new biomarker development and validation is dramatically slow. At present, none of the candidate genetic, cellular, or molecular biomarker has yet surpassed the clinical value of RA-specific autoantibodies, including rheumatoid factor (RF) and anti-citrullinated protein autoantibodies (ACPA). Rather, recent years have witnessed significant advancements …
Un 'sujet qui fâche' : l'évaluation des enseignants en France, entre défense statutaire, injonction au professionnalisme et autonomie professionnelle
2017
International audience; Cet article analyse les projets de réforme de l’évaluation des enseignants en France depuis la fin des années 1990 ainsi que les réactions, notamment syndicales, qu’ils ont suscitées. Cette évaluation est considérée comme un analyseur privilégié pour étudier les réactions des enseignants au développement de nouvelles politiques de reddition de comptes. A partir de méthodes qualitatives (entretiens, analyse de dépêches de presse et de corpus de documents), il étudie plus spécifiquement les systèmes de négociation des différents projets de réforme d’une évaluation régulièrement contestée mais jamais réformée au moment où nous terminons cet article. Adoptant une perspec…
Safety of Tyrosine Kinase Inhibitors in Patients With Differentiated Thyroid Cancer: Real-World Use of Lenvatinib and Sorafenib in Korea
2019
Background: Thyroid cancer has become the most common cancer in Korea. Generally, thyroid cancer patients have a good prognosis; however, 15–20% of patients experience recurrence or distant metastasis or are refractory to standard treatment. We assessed the safety of sorafenib and lenvatinib in patients with advanced or metastatic radioactive iodine-refractory differentiated thyroid cancers (DTC) consecutively treated at a tertiary center in South Korea.Methods: We retrospectively reviewed the charts of all consecutive patients with DTC treated during ≥6 months with lenvatinib (February 2016–April 2018) and sorafenib (January 2014–April 2018) at Gangnam Severance Hospital. Patients were tre…
Safety and immunogenicity of the PRAME cancer immunotherapeutic in metastatic melanoma: results of a phase I dose escalation study
2016
Purpose The PRAME tumour antigen is expressed in several tumour types but in few normal adult tissues. A dose-escalation phase I/II study (NCT01149343) assessed the safety, immunogenicity and clinical activity of the PRAME immunotherapeutic (recombinant PRAME protein (recPRAME) with the AS15 immunostimulant) in patients with advanced melanoma. Here, we report the phase I dose-escalation study segment. Patients and methods Patients with stage IV PRAME-positive melanoma were enrolled to 3 consecutive cohorts to receive up to 24 intramuscular injections of the PRAME immunotherapeutic. The RecPRAME dose was 20, 100 or 500 µg in cohorts 1, 2 and 3, respectively, with a fixed dose of AS15. Advers…
Common variants at VRK2 and TCF4 conferring risk of schizophrenia
2011
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field. Common sequence variants have recently joined rare structural polymorphisms as genetic factors with strong evidence for association with schizophrenia. Here we extend our previous genome-wide association study and meta-analysis (totalling 7 946 cases and 19 036 controls) by examining an expanded set of variants using an enlarged follow-up sample (up to 10 260 cases and 23 500 controls). In addition to previously reported alleles in the major histocompatibility complex region, near neurogranin (NRGN) and in an intron of transcription factor 4 (TCF4), we find two novel variants show…
Children's help seeking: the role of parenting
2008
Abstract Ninety-nine families with a school-age child participated in this study, aimed at analysing the relationship between parenting and children's help seeking. The parenting data included self-reports on parents' child-rearing principles and behavioural observations during parent–child interactions. To test help seeking, the children were placed in a problem-solving situation and had the opportunity to seek help from the experimenter. For girls, higher levels of parental nurturance were linked to longer thinking times preceding help seeking and to lessened capacity to reuse previously received help. For boys, higher levels of fathers' emotional warmth were related to higher rates of ir…