Search results for "4-O"
showing 10 items of 457 documents
CCDC 285889: Experimental Crystal Structure Determination
2006
Related Article: B.Frackowiak, K.Ochalik, A.Bialonska, Z.Ciunik, C.Wawrzenczyk, S.Lochynski|2006|Tetrahedron:Asymm.|17|124|doi:10.1016/j.tetasy.2005.11.025
CCDC 285890: Experimental Crystal Structure Determination
2006
Related Article: B.Frackowiak, K.Ochalik, A.Bialonska, Z.Ciunik, C.Wawrzenczyk, S.Lochynski|2006|Tetrahedron:Asymm.|17|124|doi:10.1016/j.tetasy.2005.11.025
CCDC 1952561: Experimental Crystal Structure Determination
2020
Related Article: Gianluca Ambrosi, M. Paz Clares, Isabel Pont, Mauro Formica, Vieri Fusi, Angela Ricci, Paola Paoli, Patrizia Rossi, Enrique García-España, Mario Inclán|2020|Dalton Trans.|49|1897|doi:10.1039/C9DT04764F
Unexpected Substituent Effects in the Iso-Heterocyclic Boulton-Katritzky Rearrangement of 3-Aroylamino-5-methyl-1,2,4-oxadiazoles: A Mechanistic Stud…
2019
The kinetics of the iso-heterocyclic mononuclear rearrangement of some 3-aroylamino-5-methyl-1,2,4-ozadiazoles was carefully examined under largely variable acidic or alkaline conditions. This reaction may proceed via two different mechanistic pathways (an uncatalyzed and a base-catalyzed one), as accounted for also by the evaluation of the relevant activation parameters. Substituent effects, as quantified by means of the Hammett’s equation, appear relatively modest; however, they reveal some interesting anomalies, which enabled us to draw a very precise picture of the intimate reaction course.
Investigation on Quantitative Structure-Activity Relationships of 1,3,4-Oxadiazole Derivatives as Potential Telomerase Inhibitors.
2020
Background:Telomerase, a reverse transcriptase, maintains telomere and chromosomes integrity of dividing cells, while it is inactivated in most somatic cells. In tumor cells, telomerase is highly activated, and works in order to maintain the length of telomeres causing immortality, hence it could be considered as a potential marker to tumorigenesis.A series of 1,3,4-oxadiazole derivatives showed significant broad-spectrum anticancer activity against different cell lines, and demonstrated telomerase inhibition.Methods:This series of 24 N-benzylidene-2-((5-(pyridine-4-yl)-1,3,4-oxadiazol-2yl)thio)acetohydrazide derivatives as telomerase inhibitors has been considered to carry out QSAR studies…
CCDC 915397: Experimental Crystal Structure Determination
2013
Related Article: M.Saccone,G.Cavallo,P.Metrangolo,A.Pace,I.Pibiri,T.Pilati,G.Resnati,G.Terraneo|2013|CrystEngComm|15|3102|doi:10.1039/C3CE40268A
The synthesis of fluorinated heteroaromatic compounds. Part 1. Five-membered rings with more than two heteroatoms. A review
2005
(2005). THE SYNTHESIS OF FLUORINATED HETEROAROMATIC COMPOUNDS. PART 1. FIVE-MEMBERED RINGS WITH MORE THAN TWO HETEROATOMS. A REVIEW. Organic Preparations and Procedures International: Vol. 37, No. 5, pp. 447-506.
CCDC 1046555: Experimental Crystal Structure Determination
2015
Related Article: Agris Be̅rziņš , Edgars Skarbulis , and Andris Actiņš|2015|Cryst.Growth Des.|15|2337|doi:10.1021/acs.cgd.5b00138
Synthesis and anti-HIV activity of 2,3-diaryl-1,3-thiazolidin-4-(thi)one derivatives.
2002
Several 2,3-diaryl-1,3-thiazolidine-4-thione derivatives and 2,3-diaryl-1,3-thiazolidin-4-ones bearing a methyl group at C-5 position have been synthesized and tested as anti-HIV agents. The results of the in vitro tests showed that some of them proved to be effective inhibitors of HIV-1 replication.
CCDC 1481997: Experimental Crystal Structure Determination
2016
Related Article: Fangfang Pan, Ngong Kodiah Beyeh, Robin H. A. Ras, Kari Rissanen|2016|CrystEngComm|18|5724|doi:10.1039/C6CE01229A