Search results for "4-benzotriazine"

showing 4 items of 4 documents

An overview on the recent developments of 1,2,4-triazine derivatives as anticancer compounds

2017

The synthesis, the antitumor activity, the SAR and, whenever described, the possible mode of action of 1,2,4-triazine derivatives, their N-oxides, N,. N'-dioxides as well as the benzo- and hetero-fused systems are reported. Herein are treated derivatives disclosed to literature from the beginning of this century up to 2016. Among the three possible triazine isomers, 1,2,4-triazines are the most studied ones and many derivatives having remarkable antitumor activity have been reported in the literature and also patented reaching advanced phases of clinical trials.

0301 basic medicine4-benzotriazine124-triazineAntineoplastic AgentsChemistry Techniques SyntheticAntiproliferative activity01 natural sciences03 medical and health scienceschemistry.chemical_compoundNeoplasmsDrug DiscoveryOrganic chemistryAnimalsHumans124-triazineMode of action124-benzotriazineTriazineAntitumor activityPharmacology010405 organic chemistryChemistryTriazinesNitrogen heterocyclesDrug Discovery3003 Pharmaceutical Science1; 2; 4-benzotriazine; 1; 2; 4-triazine; Antiproliferative activity; Antitumor activity; Nitrogen heterocycles; Pharmacology; Drug Discovery3003 Pharmaceutical Science; Organic ChemistryOrganic ChemistryGeneral MedicineCombinatorial chemistrySettore CHIM/08 - Chimica Farmaceutica0104 chemical sciences030104 developmental biologyNitrogen heterocycleDrug Screening Assays AntitumorAntitumor activity
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CCDC 1955680: Experimental Crystal Structure Determination

2020

Related Article: Christos P. Constantinides, Daniel B. Lawson, Georgia A. Zissimou, Andrey A. Berezin, Aaron Mailman, Maria Manoli, Andreas Kourtellaris, Gregory M. Leitus, Rodolphe Clérac, Heikki M. Tuononen, Panayiotis A. Koutentis|2020|CrystEngComm|22|5453|doi:10.1039/D0CE00789G

Space GroupCrystallography3-phenyl-1-(pyridin-2-yl)-14-dihydro-124-benzotriazine radicalCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 1955684: Experimental Crystal Structure Determination

2020

Related Article: Christos P. Constantinides, Daniel B. Lawson, Georgia A. Zissimou, Andrey A. Berezin, Aaron Mailman, Maria Manoli, Andreas Kourtellaris, Gregory M. Leitus, Rodolphe Clérac, Heikki M. Tuononen, Panayiotis A. Koutentis|2020|CrystEngComm|22|5453|doi:10.1039/D0CE00789G

Space GroupCrystallography3-phenyl-1-(pyridin-2-yl)-14-dihydro-124-benzotriazine radicalCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 1057512: Experimental Crystal Structure Determination

2015

Related Article: Ian S. Morgan, Akseli Mansikkamäki, Georgia A. Zissimou, Panayiotis A. Koutentis, Mathieu Rouzières, Rodolphe Clérac and Heikki M. Tuononen|2015|Chem.-Eur.J.|21|15843|doi:10.1002/chem.201501343

Space GroupCrystallographyCrystal System1-Phenyl-3-(pyridin-2-yl)-14-dihydro-124-benzotriazineCrystal StructureCell ParametersExperimental 3D Coordinates
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