Search results for "4-dicarboxylate"

showing 10 items of 11 documents

Transmembrane signaling and cytoplasmic signal conversion by dimeric transmembrane helix 2 and a linker domain of the DcuS sensor kinase

2020

Transmembrane (TM) signaling is a key process of membrane-bound sensor kinases. The C4-dicarboxylate (fumarate) responsive sensor kinase DcuS of Escherichia coli is anchored by TM helices TM1 and TM2 in the membrane. Signal transmission across the membrane relies on the piston-type movement of the periplasmic part of TM2. To define the role of TM2 in TM signaling, we use oxidative Cys cross-linking to demonstrate that TM2 extends over the full distance of the membrane and forms a stable TM homodimer in both the inactive and fumarate-activated state of DcuS. An S186xxxGxxxG194 motif is required for the stability and function of the TM2 homodimer. The TM2 helix further extends on the periplas…

0301 basic medicineCytoplasmGpA glycophorin AC4DC C4-dicarboxylateCL cross-linkingpiston-typeMBP maltose-binding proteinBiochemistry03 medical and health sciencesProtein DomainsDcuSEscherichia coli(Gly)xxx(Gly) motifMolecular Biologysensor kinasefumarate030102 biochemistry & molecular biologyChemistryEscherichia coli ProteinsCell MembraneHistidine kinaseGene Expression Regulation BacterialCell BiologyPeriplasmic spacelinkerTransmembrane proteinoxidative Cys cross-linkingTransmembrane domain030104 developmental biologyMembrane proteinProtein kinase domainHelixBiophysicsProtein MultimerizationProtein Kinasestransmembrane signalingLinkerResearch ArticleTM transmembraneJournal of Biological Chemistry
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Identification of a third secondary carrier (DcuC) for anaerobic C4-dicarboxylate transport in Escherichia coli: roles of the three Dcu carriers in u…

1996

In Escherichia coli, two carriers (DcuA and DcuB) for the transport of C4 dicarboxylates in anaerobic growth were known. Here a novel gene dcuC was identified encoding a secondary carrier (DcuC) for C4 dicarboxylates which is functional in anaerobic growth. The dcuC gene is located at min 14.1 of the E. coli map in the counterclockwise orientation. The dcuC gene combines two open reading frames found in other strains of E. coli K-12. The gene product (DcuC) is responsible for the transport of C4 dicarboxylates in DcuA-DcuB-deficient cells. The triple mutant (dcuA dcuB dcuC) is completely devoid of C4-dicarboxylate transport (exchange and uptake) during anaerobic growth, and the bacteria are…

DNA BacterialMutantMolecular Sequence DataBiologymedicine.disease_causeMicrobiologyGene productBacterial ProteinsmedicineEscherichia coliDicarboxylic AcidsAmino Acid SequenceAnaerobiosisMolecular BiologyEscherichia coliPeptide sequenceGeneDicarboxylic Acid TransportersBase SequenceSequence Homology Amino AcidEscherichia coli ProteinsChromosome MappingBiological Transportbiology.organism_classificationIsoenzymesOpen reading frameMutagenesis InsertionalBiochemistryC4-dicarboxylate transportCarrier ProteinsBacteriaResearch ArticleJournal of bacteriology
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CCDC 150223: Experimental Crystal Structure Determination

2001

Related Article: Dieter Schollmeyer, Dieter Gröschl and Herbert Meier|2016|Z.Naturforsch.,B:Chem.Sci.|71|345|doi:10.1515/znb-2015-0201

Space GroupCrystallographyCrystal SystemCrystal Structure44'-Bi(diethyl 45-dihydro-1-benzothiepine-24-dicarboxylate)Cell ParametersExperimental 3D Coordinates
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CCDC 230045: Experimental Crystal Structure Determination

2005

Related Article: M.Brunner, P.Saarenketo, T.Straub, K.Rissanen, A.M.P.Koskinen|2004|Eur.J.Org.Chem.|2004|3879|doi:10.1002/ejoc.200400207

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parameters(2R3S)-3-t-butyl 4-methyl 2-t-butyl-12-oxazolidine-34-dicarboxylateExperimental 3D Coordinates
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CCDC 907837: Experimental Crystal Structure Determination

2014

Related Article: Inguna Goba, Baiba Turovska, Sergey Belyakov, Edvards Liepinsh|2014|J.Mol.Struct.|1074|549|doi:10.1016/j.molstruc.2014.06.044

Space GroupCrystallographyCrystal SystemCrystal StructureCell ParametersDimethyl 5-acetyl-26-dimethyl-14-dihydropyridine-34-dicarboxylateExperimental 3D Coordinates
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CCDC 1574211: Experimental Crystal Structure Determination

2020

Related Article: Błażej Dziuk, Krzysztof Ejsmont, Bartosz Zarychta|2020|J.Mol.Struct.|1209|127945|doi:10.1016/j.molstruc.2020.127945

Space GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinatesdiethanaminium benzene-14-dicarboxylate
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CCDC 910389: Experimental Crystal Structure Determination

2013

Related Article: Y.Inokuma,S.Yoshioka,J.Ariyoshi,T.Arai,Y.Hitora,K.Takada,S.Matsunaga,K.Rissanen,M.Fujita|2013|Nature (London)|495|461|doi:10.1038/nature11990

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parameterscatena-[tetrakis(mu~3~-246-tris(Pyridin-4-yl)-135-triazine)-dodecakis(iodo)-hexa-zinc(ii) (dimethyl cubane-14-dicarboxylate) clathrate unknown solvate]Experimental 3D Coordinates
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CCDC 1415388: Experimental Crystal Structure Determination

2018

Related Article: Youwen Xu, Aylin Sibel Cankaya, Ruma Hoque, So Jeong Lee, Colleen Shea, Lena Kersting, Michael Schueller, Joanna S. Fowler, David Szalda, David Alexoff, Barbara Riehl, Tassilo Gleede, Richard A. Ferrieri, Wenchao Qu|2018|Chem.-Eur.J.|24|6848|doi:10.1002/chem.201801029

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parametersdi-t-butyl 123-oxathiazolidine-34-dicarboxylate 22-dioxideExperimental 3D Coordinates
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CCDC 1904525: Experimental Crystal Structure Determination

2019

Related Article: Y. Gautier, T. Maris, W.G. Skene|2019|Acta Crystallogr.,Sect.E:Cryst.Commun.|75|589|doi:10.1107/S2056989019003864

Space GroupCrystallographyCrystal SystemCrystal Structurediethyl 2-amino-5-((4-(bis(4-methylphenyl)amino)benzene-1-carbonyl)amino)thiophene-34-dicarboxylateCell ParametersExperimental 3D Coordinates
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CCDC 1532008: Experimental Crystal Structure Determination

2017

Related Article: P. J. Llabres-Campaner, J. Pitarch-Jarque, R. Ballesteros-Garrido, B. Abarca, R. Ballesteros, E. García-España|2017|Dalton Trans.|46|7397|doi:10.1039/C7DT00855D

Space GroupCrystallographyzinc bicyclo(2.2.2)octane-14-dicarboxylate diethylformamide solvateCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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