Search results for "407"
showing 10 items of 81 documents
Impact of uncharged and charged stabilizers on in vitro drug performances of clarithromycin nanocrystals
2018
The purpose of this study was to evaluate the effect of charge on the in vitro drug performances of clarithromycin nanocrystals. To prepare different charges of nanocrystals, media milling was employed with the use of different stabilizing systems. The uncharged nanocrystals were prepared from poloxamer 407. The negatively and positively charged nanocrystals were stabilized using a combination of poloxamer 407 with sodium lauryl sulfate (SLS) and cetyltrimethylammonium bromide (CTAB), respectively. After production, the particle size of the negatively and positively charged nanocrystals was smaller than that of the uncharged one. The similar particle size of variously charged clarithromycin…
Antibacterial drug release from a biphasic gel system: Mathematical modelling
2019
Bacterial infections represent an important drawback in the orthopaedic field, as they can develop either immediately after surgery procedures or after some years. Specifically, in case of implants, they are alleged to be troublesome as their elimination often compels a surgical removal of the infected implant. A possible solution strategy could involve a local coating of the implant by an antibacterial system, which requires to be easily applicable, biocompatible and able to provide the desired release kinetics for the selected antibacterial drug. Thus, this work focusses on a biphasic system made up by a thermo-reversible gel matrix (Poloxamer 407/water system) hosting a dispersed phase (…
On-site Experimental Study of HCFC-22 Substitution with HFCs Refrigerants
2012
Abstract The European Regulation no 2037/2000 has banned manufacturing HCFC refrigerants from January 1st 2010, although its use is allowed up to 2015 if the fluids come from a recycling process. This situation creates the need for developing new working fluids to replace the HCFC in the refrigeration plants now in operation. Among all the HCFCs the R22 is the most widely used in a wide range of applications, especially in air conditioning. This paper presents the results of an experimental analysis comparing the performance of a vapour compression refrigerating unit operating with R22, and its performance in comparison to some HFCs fluids, substituting the former. In particular, the plant …
Warren Buffett versus Zvi Bodie: Should You Buy Or Sell Put Options?
2021
Academics and investment professionals often disagree when it comes to investment advice. Legendary investor Warren Buffett is a proponent of time diversification and firmly believes that stocks are less risky in the long run. Therefore, he often sells long-term put options instead of buying them for portfolio protection. By contrast, the famous finance professor Zvi Bodie argues that time diversification is a fallacy and, therefore, his advice to fund managers is to buy long-term portfolio insurance. In this article, we consider the optimal portfolio choice problem for a loss-averse investor. First, we demonstrate that our loss-averse investor subscribes to the principle of time diversific…
El monogramista F.D.V. ¿Frans de Vriendt? A propósito de una Susana y los viejos firmada y fechada en 1543
2017
En este artículo analizamos una pintura flamenca inédita, que representa la escena de Susana y los viejos. Se conserva en una colección particular de Cartagena (Murcia). Está fechada en 1543 y firmada por F.D.V., monograma que plantea la principal incógnita de nuestra investigación. Tales siglas hacen pensar de inmediato en el pintor Frans Floris de Vriendt. En este sentido, los rasgos estilísticos de la obra están próximos al espíritu de este maestro. Sin embargo, diversas cuestiones nos impiden confirmar por el momento tal autoría. En el texto desarrollamos estas hipótesis y definimos la personalidad artística del que denominamos Monogramista F.D.V. In this paper, we analyze an unpublishe…
In vitro evaluation of poloxamer in situ forming gels for bedaquiline fumarate salt and pharmacokinetics following intramuscular injection in rats
2019
Graphical abstract
Dissolution and dissolution/permeation experiments for predicting systemic exposure following oral administration of the BCS class II drug clarithrom…
2017
In order to save time and resources in early drug development, in vitro methods that correctly predict the formulation effect on oral drug absorption are necessary. The aim of this study was to 1) evaluate various BCS class II drug formulations with in vitro methods and in vivo in order to 2) determine which in vitro method best correlates with the in vivo results. Clarithromycin served as model compound in formulations with different particle sizes and content of excipients. The performed in vitro experiments were dissolution and dissolution/permeation experiments across two types of membrane, Caco-2 cells and excised rat intestinal sheets. The in vivo study was performed in rats. The oral…
Dynamics and Limits of Regulatory Privatization: Reorganizing audit oversight in Russia
2019
Accounting and auditing are often cited as key sites where business regulation has been privatized, globalized and neoliberalized. Yet, these sites have also undergone a legitimacy crisis in recent years, marked by a shift from self-regulation to increased public oversight. This paper investigates these developments by reference to the evolution of a public/private audit oversight regime (audit of the auditors) in Russia. We show how, in the early stages of post-Soviet reforms, old state-administered forms of financial oversight were replaced with market-oriented arrangements (peer reviews) offered by newly founded private professional accountancy associations as a service to their members.…
In-line monitoring of the photooxidation behaviour of a PP/clay nanocomposite through creep measurements
2016
Abstract The photooxidation behaviour of a polypropylene/organomodified clay nanocomposite sample has been monitored by means of a new apparatus through the record of the creep curves measured while the sample is subjected to the contemporary action of temperature, tensile strength and UV radiation. The creep curves of the irradiated samples are higher than those of the non-irradiated samples and the curves diverge when the molecular weight begins to decrease because of the degradation. At the same the formation of carbonyl groups is observed. The creep curves of the non-irradiated and irradiated samples give, then, an immediate evaluation of the begin and of the development of the photooxi…
SIK2 orchestrates actin-dependent host response upon Salmonella infection
2021
Significance Through conducting quantitative proteomics upon Salmonella infection, we identified a SIK2 signaling network, implementing the kinase into a so far concealed biological function. Our data exposed SIK2 as a central orchestrator of an actin regulatory network, coordinating the stability of Salmonella-containing vacuole (SCV) and cellular actin assembly, in order to limit the acute phase of the infection. Most strikingly, SIK2 is not exclusively acting locally on actin assembly associated with the SCV but impacts the actin cytoskeleton architecture in its entirety upon Salmonella infection. Our work provides a mechanistic framework for how the actin cytoskeleton is regulated and h…