Search results for "40"
showing 10 items of 17345 documents
The reactivity of neonatal rabbits to the mammary pheromone as a probe for viability
2012
International audience; Newborn rabbits depend on a daily nursing interaction with the mother to gain milk and to survive. During this interaction, they localise and seize the nipples displaying a typical behaviour triggered by maternal odour cues. The mammary pheromone constitutes such a signal in domestic rabbits: it elicits sucking-related movements in more than 90% of the pups. However, some newborns remain unresponsive to the presentation of the pheromone, even pups apparently healthy and highly motivated to suck. The main goal of the present study was therefore to explore the link between the unresponsiveness of rabbit pups to the mammary pheromone and their growth and survival in bre…
Molecular Mechanisms of the Blockage of Glioblastoma Motility
2021
Glioblastoma (GBM) is the most common and lethal brain tumor. GBM has a remarkable degree of motility and is able to infiltrate the healthy brain. In order to perform a rationale-based drug-repositioning study, we have used known inhibitors of two small Rho GTPases, Rac1 and Cdc42, which are upregulated in GBM and are involved in the signaling processes underlying the orchestration of the cytoskeleton and cellular motility. The selected inhibitors (R-ketorolac and ML141 for Cdc42 and R-ketorolac and EHT 1864 for Rac1) have been successfully employed to reduce the infiltration propensity of GBM in live cell imaging studies. Complementarily, all-atom simulations have elucidated the molecular …
Despidos laborales. Fracturas sociales e identitarias
2008
Los varios miles de despidos colectivos que han inaugurado el comienzo de siglo en España no suponen solo casi doscientos mil empleos destruidos, muchos de ellos con una larguísima vigencia, otros tantos proyectos de vida quebrados, sino también formas de reproducción social, de identidad rotas, instituciones y garantías sociales que se desmoronan. Sorprendentemente, estas fracturas sociales quedan eclipsadas con frecuencia tras unos discursos que apelan a los imperativos económicos, a las exigencias de la modernización, a los requerimientos de la lógica de la globalización. En el presente artículo se indagan las consecuencias del quebranto de la vinculación social entretejida en la segunda…
Automated Railway Signs Detection. Preliminary Results
2019
Abstract Nowadays safety in railways is mostly achieved by automated system technologies such as ERTMS/ETCS. Nevertheless, on local railways (suburban and regional lines) several tasks still depend on the choices and actions of a human crew. With the aim to improve safety in such type of railways, this research proposes a system for the automatic detection and recognition of railway signs by means of the digital image processing technique. First field applications, carried out on the Italian railway network, show that the proposed system is very accurate (the percentage of correctly detected railway signs is about 97%), even at high train speeds.
Yhtiöittäminen – valtion rakennetun kulttuuriperinnön haaksirikko?
2015
Ympäristönsuojelussa on tapahtunut viidenkymmenen vuoden aikana suuri muutos viranomaislähtöisestä suojelusta yhteisölähtöiseksi suojeluksi. Suomi on ratifioinut useita kansainvälisiä sopimuksia, joilla korostetaan kulttuuri- ja luonnonympäristöjen merkitystä ja taataan niiden säilyminen. Siitä huolimatta, valtion kiinteistöpolitiikan seurauksena, yliopistojen arvokiinteistöt ovat joutuneet uhanalaisiksi. Kiinteistöt omistavan osakeyhtiön ja yliopistojen ansaintalogiikat eivät kohtaa, eikä kummankaan tahon tehtäviin kuulu kulttuuriympäristöjen vaaliminen. Miten tähän on tultu? Artikkelissamme esimerkkikohteena on Jyväskylän yliopiston Seminaarinmäki ja sen Villa Rana -rakennus. peerReviewed
Kirkonrakentajasuku Rijf. Pohjalaisen kirkonrakentajasuvun rakennus- ja suunnittelutuotanto sekä toiminta kustavilaisen aikakauden Suomessa
2016
This dissertation deals with the building and design work of the church builder family Rijf in Österbotten during the Gustavian Period. The Rijfs were Finland- Swedes and entailed four mason-based master builders: Thomas Rijf (1726-1803), his sons Jacob (1753-1808) and Carl (1756-1801), and Jacob´s son Carl Jacobsson Rijf (1783-1808). The most famous member of the family was Jacob Rijf. He was the first Finnish master builder to study at the Royal Swedish Academy of Arts and was supervised by the leading architects of the Board of Public Works and Buildings, Carl Fredrik Adelcrantz (1716-1796) and Olof Tempelman (1745-1816). In 1794 Jacob Rijf was appointed as the provincial master builder …
Strongly Coupled Coherent Phonons in Single-Layer MoS 2
2019
We present a transient absorption setup combining broadband detection over the visible-UV range with high temporal resolution ($\sim$20fs) which is ideally suited to trigger and detect vibrational coherences in different classes of materials. We generate and detect coherent phonons (CPs) in single layer (1L) MoS$_2$, as a representative semiconducting 1L-transition metal dichalcogenide (TMD), where the confined dynamical interaction between excitons and phonons is unexplored. The coherent oscillatory motion of the out-of-plane $A'_{1}$ phonons, triggered by the ultrashort laser pulses, dynamically modulates the excitonic resonances on a timescale of few tens fs. We observe an enhancement by…
Proton reduction by phosphinidene-capped triiron clusters
2021
Bis(phosphinidene)-capped triiron carbonyl clusters, including electron rich derivatives formed by substitution with chelating diphosphines, have been prepared and examined as proton reduction catalysts. Treatment of the known cluster [Fe3(CO)9(µ3-PPh)2] (1) with various diphosphines in refluxing THF (for 5, refluxing toluene) afforded the new clusters [Fe3(CO)7(µ3-PPh)2(κ2-dppb)] (2), [Fe3(CO)7(µ3-PPh)2(κ2-dppv)] (3), [Fe3(CO)7(µ3-PPh)2(κ2-dppe)] (4) and [Fe3(CO)7(µ3-PPh)2(µ-κ2-dppf)] (5) in moderate yields, together with small amounts of the corresponding [Fe3(CO)8(µ3-PPh)2(κ1-Ph2PxPPh2)] cluster (x = -C4H6-, -C2H2-, -C2H4-, -C3H6-, -C5H4FeC5H4-). The molecular structures of complexes 3 a…
Proteins in Ionic Liquids: Reactions, Applications, and Futures
2019
Biopolymer processing and handling is greatly facilitated by the use of ionic liquids, given the increased solubility, and in some cases, structural stability imparted to these molecules. Focussing on proteins, we highlight here not just the key drivers behind protein-ionic liquid interactions that facilitate these functionalities, but address relevant current and potential applications of protein-ionic liquid interactions, including areas of future interest.
La relevancia de la investigación social a nivel local para el diseño de políticas municipales: el diagnóstico social de la ciudad de Valencia
2019
Presentamos algunos de los resultados obtenidos con la investigación ?Diagnóstico Social de la Ciudad de València, 2017?, realizada en el marco de un convenio de colaboración entre el Ayuntamiento de València, a través de la Concejalía de Servicios Sociales y del Servicio de Bienestar Social e Integración y la Universitat de València (Red Incluye). Uno de los rasgos más relevantes de la investigación fue su enfoque local, territorial y subterritorial en el desarrollo metodológico y técnico de la investigación al estarorientada a proporcionar información actualizada, inédita y relevante para las funciones del personal técnico de las once áreas de los Centros Municipales de Servicios Sociales…