Search results for "41"
showing 10 items of 3365 documents
Semi-Mechanistic Pharmacokinetic Model to Guide the Dose Selection of Nimotuzumab in Patients with Autosomal Dominant Polycystic Kidney Disease
2020
Autosomal dominant polycystic kidney disease (ADPKD) is a genetic disease characterized by an overexpression of epidermal growth factor receptor (EGFR). Nimotuzumab is a recombinant humanized monoclonal antibody against human EGFR. The aim of this study was to develop a population pharmacokinetic model for nimotuzumab and to identify demographic and clinical predictive factors of the pharmacokinetic variability. The population pharmacokinetics (PopPK) of nimotuzumab was characterized using a nonlinear mixed-effect modeling approach with NONMEM®
Population Pharmacokinetics of Palbociclib in aReal-World Situation
2021
Palbociclib is an oral cyclin-dependent kinase inhibitor that is used in combination with aromatase inhibitors in the treatment of postmenopausal women with metastatic breast cancer. Its metabolism profile is associated with an important interpatient variability. We performed a population pharmacokinetics study of palbociclib in women routinely followed in a cancer center. One hundred and fifty-one samples were analyzed. The sampling times after administration ranged from 0.9 to 75 h and the samples were taken between 1 and 21 days after the beginning of the palbociclib cycle. Palbociclib was determined using a validated mass spectrometry method. The best model that described the concentrat…
The location of an international logistics center in Poland as a part of The One Belt One Road Initiative
2019
Background: The One Belt One Road initiative opens up many development opportunities for Central and Eastern European countries, some related to the possible construction of a logistics center in this area. For Poland, such an investment would also bring many benefits, not only due to infrastructure development, but also through acceleration of economic growth and job creation. In this context, the crucial issue becomes, what should be the role of an international logistics center and where should it be located. Due to the novelty of the subject, there is a shortcoming of scientific papers related to this issue. The scientific goal of the present paper is to fulfill the gap and to address …
Synchronicity matters: defining the characteristics of digital generations
2015
This paper investigates whether or not the proposition that the second digital generation (or so-called digital natives) is more engaged in social use of the Internet than older generations is tenable. By analysing nationally representative questionnaire-based survey data collected from Finland in 2011 (N = 612), the study shows that rather than social use of the Internet in general, it is the synchronicity of online communication that distinguishes user generations. Results show that, in contrast to asynchronous modes of online communication (e.g. social networking sites, blogs and online discussion forums), synchronous modes (e.g. instant messaging and Internet calls) are clearly generati…
Improving Brain Creatine Uptake by Klotho Protein Stimulation: Can Diet Hit the Big Time?
2021
Creatine plays a pivotal role in cellular bioenergetics, acting as a temporal and spatial energy buffer in cells with high and fluctuating energy requirements (1). Jeopardizing delicate creatine homeostasis can be detrimental to many energy-demanding tissues, including the brain. For instance, cerebral creatine hypometabolism accompanies various neurological conditions, including a number of developmental disorders (2, 3), neurodegenerative and cerebrovascular diseases (4, 5), and brain cancer (6). A reduced creatine availability in the brain has been thus recognized as an apposite therapeutic target, and supplying exogenous creatine to compensate for a disease-driven shortfall emerged as a…
The giant spectrin βV couples the molecular motors to phototransduction and Usher syndrome type I proteins along their trafficking route.
2013
International audience; Mutations in the myosin VIIa gene cause Usher syndrome type IB (USH1B), characterized by deaf-blindness. A delay of opsin trafficking has been observed in the retinal photoreceptor cells of myosin VIIa-deficient mice. We identified spectrin bV, the mammalian b-heavy spectrin, as a myosin VIIa-and rhodopsin-interacting partner in photoreceptor cells. Spectrin bV displays a polarized distribution from the Golgi apparatus to the base of the outer segment, which, unlike that of other b spectrins, matches the trafficking route of opsin and other phototransduction proteins. Formation of spectrin bV-rhodopsin complex could be detected in the differentiating photoreceptors a…
Emergence of extreme events in fiber-based parametric processes driven by a partially incoherent pump wave
2009
Modulation instability (MI) generated by a picosecond coherent pulse has been recently identified as the key element of the generation of optical rogue-waves in supercontinuum-based systems [1]. Similar rare but highly energetic pulse structures can also appear in non-solitonic configurations such as Raman amplifiers driven by a partially incoherent pump wave propagating in fibres with low group velocity dispersion [2]. Therefore, one may wonder whether optical rogue-like event can also occur in MI-based amplifier because both Raman and parametric amplifiers benefit from a quasi-instantaneous gain. We provide here experimental evidence of rare optical events in a parametric amplifier in pre…
Banki-Michell Optimal Design by Computational Fluid Dynamics Testing and Hydrodynamic Analysis
2013
In hydropower, the exploitation of small power sources requires the use of small turbines that combine efficiency and economy. Banki-Michell turbines represent a possible choice for their simplicity and for their good efficiency under variable load conditions. Several experimental and numerical tests have already been designed for examining the best geometry and optimal design of cross-flow type machines, but a theoretical framework for a sequential design of the turbine parameters, taking full advantage of recently expanded computational capabilities, is still missing. To this aim, after a review of the available criteria for Banki-Michell parameter design, a novel two-step procedure is de…
Optimal design of complex passive-damping systems for vibration control of large structures: An energy-to-peak approach
2014
Published version of an article in the journal: Abstract and Applied Analysis. Also available from the publisher at: http://dx.doi.org/10.1155/2014/510236 Open Access We present a new design strategy that makes it possible to synthesize decentralized output-feedback controllers by solving two successive optimization problems with linear matrix inequality (LMI) constraints. In the initial LMI optimization problem, two auxiliary elements are computed: a standard state-feedback controller, which can be taken as a reference in the performance assessment, and a matrix that facilitates a proper definition of the main LMI optimization problem. Next, by solving the second optimization problem, the …
Nopal Cactus (Opuntia ficus-indica) as a Source of Bioactive Compounds for Nutrition, Health and Disease
2014
Opuntia ficus-indica, commonly referred to as prickly pear or nopal cactus, is a dicotyledonous angiosperm plant. It belongs to the Cactaceae family and is characterized by its remarkable adaptation to arid and semi-arid climates in tropical and subtropical regions of the globe. In the last decade, compelling evidence for the nutritional and health benefit potential of this cactus has been provided by academic scientists and private companies. Notably, its rich composition in polyphenols, vitamins, polyunsaturated fatty acids and amino acids has been highlighted through the use of a large panel of extraction methods. The identified natural cactus compounds and derivatives were shown to be e…