Search results for "42"

Inducing Cold-Sensitivity in the Frigophilic Fly Drosophila montana by RNAi

2016

The work was supported by CNPq (Fellowship to FMV) and a NERC Studentship to DJP. Cold acclimation is a critical physiological adaptation for coping with seasonal cold. By increasing their cold tolerance individuals can remain active for longer at the onset of winter and can recover more quickly from a cold shock. In insects, despite many physiological studies, little is known about the genetic basis of cold acclimation. Recently, transcriptomic analyses in Drosophila virilis and D.montana revealed candidate genes for cold acclimation by identifying genes upregulated during exposure to cold. Here, we test the role of myo-inositol-1-phosphate synthase (Inos), in cold tolerance in D. montana …

Integrin α2β1 Mediates Isoform-Specific Activation of p38 and Upregulation of Collagen Gene Transcription by a Mechanism Involving the α2 Cytoplasmic…

1999

Two collagen receptors, integrins alpha1beta1 and alpha2beta1, can regulate distinct functions in cells. Ligation of alpha1beta1, unlike alpha2beta1, has been shown to result in recruitment of Shc and activation of the Ras/ERK pathway. To identify the downstream signaling molecules activated by alpha2beta1 integrin, we have overexpressed wild-type alpha2, or chimeric alpha2 subunit with alpha1 integrin cytoplasmic domain in human osteosarcoma cells (Saos-2) lacking endogenous alpha2beta1. The chimeric alpha2/alpha1 chain formed a functional heterodimer with beta1. In contrast to alpha2/alpha1 chimera, forced expression of alpha2 integrin resulted in upregulation of alpha1 (I) collagen gene …

Interactional means of teaming up: enacting the features of contemporary working life in a theater performance

2021

Abstract The article examines how the aspects of the social world are enacted in a theater play. The data come from a videotaped performance of a professional theater, portraying a story about a workplace organization going through a personnel training program. The aim of the study is to show how the core theme of the play – the teaming up of the personnel – is constructed in the live performance through a range of interactional means. By focusing on four core episodes of the play, the study on the one hand points out to the multiple changes taking place both within and between the different episodes of the play. On the other hand, the episodes of collective action involving the semiotic re…

The European Innovation Partnership on Active and Healthy Ageing Synergies: Protocol for a prospective observational study to measure the Impact of a…

2016

Aim of this paper is to describe the protocol of the study "Impact of a Community-based Program on Prevention and Mitigation of Frailty in community-dwelling older adults" developed in the framework of the European Innovation Partnership on Active and Healthy Ageing. This proposal has been developed by the Partnership Action groups on frailty, fall prevention and polypharmacy in older. The proposal wants to assess the impact of community-based programs aimed to counteract three main outcomes related to frailty: hospitalization, institutionalization and death. Bringing together researchers from seven European countries, the proposal aims to achieve the critical mass and the geographical exte…

Valutazione delle condizioni microclimatiche nelle sale di degenza e nelle terapie intensive.

2006

Sporadic and Familial Variants in NF1: An Explanation of the Wide Variability in Neurocognitive Phenotype?

2020

Background: Cognitive impairment is the most common neurological manifestation in NF1 and occurs in 30-70% of NF1 cases. The onset and severity of each specific cognitive deficit varies greatly from child to child, with no apparent external causes. The wide variability of phenotype is the most complex aspect in terms of management and care. Despite multiple research, the mechanism underlying the high heterogeneity in NF1 has not yet been elucidated. While many studies have focused on the effects of specific and precise genetic mutations on the NF1 phenotype, little has been done on the impact of NF1 transmission (sporadic vs. familial cases). We used a complete neuropsychological evaluation…

Public procurement: current situation and points of improvement

2015

[ES] La construcción pública ha sido, es y será uno de los pilares fundamentales del sector construcción español, si bien la actual situación de crisis económica y la reducción de la inversión pública en nuevas infraestructuras ha generado un descenso de actividad hasta niveles similares a los años noventa. El retorno a índices de actividad más elevados no solo se conseguirá con la recuperación de la economía del país, sino que será necesario realizar ciertas mejoras en los procesos de licitación con objeto de conseguir una mayor funcionalidad y flexibilidad en la contratación pública de obras.

Molecular characterization of Giardia duodenalis cysts in the Oreto river (Sicily, Southern Italy)

2012

<p><strong>Background</strong>: The presence of Giardia was investigated along the Oreto river between January 2008 and May 2009 with the aim of understanding the source of contamination by molecular typing of cysts.</p><p><strong>Methods</strong>: A total of 38 water samples (10 collected from the river mouth, 24 from the whole Oreto basin and 4 sewage samples from the Monreale treatment plant) were processed. In addition, 22 faecal samples of livestock living close to the Oreto area, were analyzed. The presence of Giardia was determined by immunofluorescence assay and their genetic characterization was achieved by a nested PCR assay targeting the …

Impianto di ventilazione e condizionamento a contaminazione controllata (VCCC),contaminazione microbica dell'aria e infezione del sito chirurgico in …

2012

Ideological, Institutional and Affective Practices of Interpersonal Violence

2020

The first chapter presents the book’s point of departure as well as its central concepts and structure. It outlines the current understandings of and theoretical approaches to the intersections of violence, gender and affect. The starting point is that gendered violence and violating practices are embedded in social structures of power and in inequalities, institutions, regimes and the symbolic order. They are manifested in human interaction as well as in cultural discourses and representations. The chapter also gives an overview of the abundant research and various perspectives involved in analysing the intersections of violence, gender and affect as well as the continuities and interconne…