Search results for "43"
showing 10 items of 1438 documents
Allele-specific silencing as therapy for familial amyotrophic lateral sclerosis caused by the p.G376D TARDBP mutation
2022
Abstract Amyotrophic lateral sclerosis is a neurodegenerative disease characterized by the degeneration of motor neurons. There is no treatment for this disease that affects the ability to move, eat, speak and finally breathe, causing death. In an Italian family, a heterozygous pathogenic missense variant has been previously discovered in Exon 6 of the gene TARDBP encoding the TAR DNA-binding protein 43 protein. Here, we developed a potential therapeutic tool based on allele-specific small interfering RNAs for familial amyotrophic lateral sclerosis with the heterozygous missense mutation c.1127G>A. We designed a small interfering RNA that was able to diminish specifically the express…
Rudzātu izloksne un tās izveides kultūrvēsturiskie apstākļi
2015
Maģistra darbā „Rudzātu izloksne un tās izveides kultūrvēsturiskie apstākļi“ analizēta Rudzātu437 teritorijas kultūrvēsture, izloksnes vokālisma īpatnības un sociolingvistiskā informācija par aptaujātajiem teicējiem. Mērķis ir noskaidrot, kā Rudzātu437 izloksnes teritorijas kultūrvēsture līdz vienota Rudzātu pagasta izveidei 1925. g. ir atstājusi iespaidu uz izloksnes izveidi un vai mūsdienās tas atspoguļojas fonētiskajā materiālā – izloksnes vokālismā. Izdarīti secinājumi par to, kādā veidā vēsturiski mainīgā teritorijas administratīvā un draudžu piederība, iedzīvotāju migrācija un atšķirīgās kontaktzonas atspoguļojas mūsdienu Rudzātu437 izloksnes teicēju valodā un vai šo teritoriju nešķēr…
El papel de la sociología en el ámbito del desarrollo local: aportaciones tras dos décadas de experiencia en la administración pública
2021
Lesioni ossee in corso di depezzamento. Indagini sperimentali
2013
Danno morale
2016
Il danno alla persona costituisce uno dei temi piu` affascinanti ed al contempo controversi dei sistemi della tradizione giuridica occidentale, tanto che non puo` destare stupore il fatto che ad esso si e` accompagnata una vasta riflessione sia sugli aspetti pratici sia sulle ricadute di teoria generale del diritto sull’illecito civile extracontrattuale. Si tratta, infatti, di una materia che lambisce i piu` eterogenei e complessi problemi che si sono agitati intorno all’istituto aquiliano e che, a tutt’oggi, ne continuano ad animare ogni discorso: la nozione positiva di danno extracontrattuale; la tipicita` o l’atipicita` della responsabilita` da torto; il significato da attribuire alla lo…
Heijastavatko työn ja perheen yhteensovittamisen kokemukset yksilön elämänarvoja?
2014
Tässä tutkimuksessa tarkasteltiin yksilön elämänarvojen yhteyttä työn ja perheen välisen ristiriidan ja rikastavuuden kokemuksiin. Analyysit perustuivat 50-vuotiaisiin Lapsesta aikuiseksi - pitkittäistutkimuksen osanottajiin (n = 156, 53 % miehiä). Schwartzin (1992) menetelmällä tarkastellut elämänarvot olivat hyväntahtoisuus, universalismi, turvallisuus, yhdenmukaisuus, hedonismi, itseohjautuvuus, suoriutuminen, stimulaatio, traditiot ja valta. Suoriutuminen ja universalismi olivat myönteisesti yhteydessä sekä työn ja perheen välisen ristiriidan että rikastavuuden kokemuksiin. Sen sijaan stimulaatio oli myönteisesti yhteydessä vain ristiriidan ja yhdenmukaisuus vain rikastavuuden kokemuksi…
Drowing in Fuel: A case report
2011
Observation of Higgs boson production in association with a top quark pair at the LHC with the ATLAS detector
2018
Physics letters / B 784, 173 - 191 (2018). doi:10.1016/j.physletb.2018.07.035
Measurement of light-by-light scattering and search for axion-like particles with 2.2 nb−1 of Pb+Pb data with the ATLAS detector
2021
We thank CERN for the very successful operation of the LHC, as well as the support staff from our institutions without whom ATLAS could not be operated efficiently. We acknowledge the support of ANPCyT, Argentina; YerPhI, Armenia; ARC, Australia; BMWFW and FWF, Austria; ANAS, Azerbaijan; SSTC, Belarus; CNPq and FAPESP, Brazil; NSERC, NRC and CFI, Canada; CERN; ANID, Chile; CAS, MOST and NSFC, China; COLCIENCIAS, Colombia; MSMT CR, MPO CR and VSC CR, Czech Republic; DNRF and DNSRC, Denmark; IN2P3-CNRS and CEA-DRF/IRFU, France; SRNSFG, Georgia; BMBF, HGF and MPG, Germany; GSRT, Greece; RGC and Hong Kong SAR, China; ISF and Benoziyo Center, Israel; INFN, Italy; MEXT and JSPS, Japan; CNRST, Mor…
Coupled fixed point results in cone metric spaces for -compatible mappings
2011
Abstract In this paper, we introduce the concepts of -compatible mappings, b-coupled coincidence point and b-common coupled fixed point for mappings F, G : X × X → X, where (X, d) is a cone metric space. We establish b-coupled coincidence and b-common coupled fixed point theorems in such spaces. The presented theorems generalize and extend several well-known comparable results in the literature, in particular the recent results of Abbas et al. [Appl. Math. Comput. 217, 195-202 (2010)]. Some examples are given to illustrate our obtained results. An application to the study of existence of solutions for a system of non-linear integral equations is also considered. 2010 Mathematics …