Search results for "43"
showing 10 items of 1438 documents
Neurotic generation of Covid-19 in Eastern Europe
2021
This article presents the results of a research survey, which shows the relationship between neuroticism and the coronavirus pandemic, which was performed among students in Poland and Ukraine. The survey was conducted online, on a sample of 1,978 respondents in Poland and 411 in Ukraine. The results indicated that average and high levels of neuroticism were observed among 61% of respondents in Poland and 47% in Ukraine. Regression analysis revealed that the main factors correlated with the level of neuroticism were educational burnout, gender, financial situation, interest in the pandemic, and satisfaction with life. As indicated by the respondents, neuroticism increases with educational bu…
Association between current physical activity and current perceived anxiety and mood in the initial phase of COVID-19 confinement
2020
The World Health Organization (WHO) has declared a world pandemic due to COVID-19, and several enacted measures such as compulsory confinement may have collateral consequences on both physical and mental health. We aimed to investigate associations between current physical activity (PA) and current perceived anxiety and mood among a sample of Spanish adults confined due to COVID-19 restrictions of movement. Using an online survey, we collected data on the Spanish adult population regarding health habits during the first days of enacted confinement. A total of 2250 participants (54.8% women) aged 35.3 (SD 13.6) completed the survey, which included questions about sociodemographic characteris…
Ambivalent Déjà-vu: World War II in the poetry of the Northern Irish Troubles
2021
This article addresses how the poetry of the Northern Irish Troubles enters into a dialogue with the memory of World War II. Poems by Michael Longley, Seamus Heaney, Derek Mahon, and Sinéad Morrissey are analysed, showing how World War II is a controversial source of comparison for these poets. While World War II provides important ways of framing the suffering and claustrophobia of the Northern Irish conflict, evident differences also mean that such comparisons are handled warily and with some irony. The poems are highly self-conscious utterances that seek to unsettle and develop generic strategies in the light of traumatic suffering. This essay draws on Michael Rothberg’s concept of mult…
Therapeutic afucosylated monoclonal antibody and bispecific T-cell engagers for T-cell acute lymphoblastic leukemia
2021
BackgroundT-cell acute lymphoblastic leukemia (T-ALL) is an aggressive disease with a poor cure rate for relapsed/resistant patients. Due to the lack of T-cell restricted targetable antigens, effective immune-therapeutics are not presently available and the treatment of chemo-refractory T-ALL is still an unmet clinical need. To develop novel immune-therapy for T-ALL, we generated an afucosylated monoclonal antibody (mAb) (ahuUMG1) and two different bispecific T-cell engagers (BTCEs) against UMG1, a unique CD43-epitope highly and selectively expressed by T-ALL cells from pediatric and adult patients.MethodsUMG1 expression was assessed by immunohistochemistry (IHC) on a wide panel of normal t…
Two Remarkably Luminous Galaxy Candidates at z ≈ 10-12 Revealed by JWST
2022
The first few 100 Myr at z > 10 mark the last major uncharted epoch in the history of the universe, where only a single galaxy (GN-z11 at z ≈ 11) is currently spectroscopically confirmed. Here we present a search for luminous z > 10 galaxies with JWST/NIRCam photometry spanning ≈1–5 μm and covering 49 arcmin2 from the public JWST Early Release Science programs (CEERS and GLASS). Our most secure candidates are two MUV ≈ −21 systems: GLASS-z12 and GLASS-z10. These galaxies display abrupt ≳1.8 mag breaks in their spectral energy distributions (SEDs), consistent with complete absorption of flux bluewards of Lyα that is redshifted to =+z12.40.3 0.1and=+z10.40.5 0.4. Lower redshift interlopers su…
Measurement of dijet production with a veto on additional central jet activity in pp collisions at sqrt(s)=7 TeV using the ATLAS detector
2011
A measurement of jet activity in the rapidity interval bounded by a dijet system is presented. Events are vetoed if a jet with transverse momentum greater than 20 GeV is found between the two boundary jets. The fraction of dijet events that survive the jet veto is presented for boundary jets that are separated by up to six units of rapidity and with mean transverse momentum 50 < p¯T < 500 GeV. The mean multiplicity of jets above the veto scale in the rapidity interval bounded by the dijet system is also presented as an alternative method for quantifying perturbative QCD emission. The data are compared to a next-to-leading order plus parton shower prediction from the powheg-box, an all-order…
The molecular characterization of a depurinated trial DNA sample can be a model to understand the reliability of the results in forensic genetics
2014
The role of DNA damage in PCR processivity/fidelity is a relevant topic in molecular investigation of aged/forensic samples. In order to reproduce one of the most common lesions occurring in postmortem tissues, a new protocol based on aqueous hydrolysis of the DNA was developed in vitro. Twenty-five forensic laboratories were then provided with 3.0 μg of a trial sample (TS) exhibiting, in mean, the loss of 1 base of 20, and a molecular weight below 300 bp. Each participating laboratory could freely choose any combination of methods, leading to the quantification and to the definition of the STR profile of the TS, through the documentation of each step of the analytical approaches selected. …
The Chaperone Activity of Clusterin is Dependent on Glycosylation and Redox Environment
2014
Background/Aims: Clusterin (CLU), also known as Apolipoprotein J (ApoJ) is a highly glycosylated extracellular chaperone. In humans it is expressed from a broad spectrum of tissues and related to a plethora of physiological and pathophysiological processes, such as Alzheimer's disease, atherosclerosis and cancer. In its dominant form it is expressed as a secretory protein (secreted CLU, sCLU). During its maturation, the sCLU-precursor is N-glycosylated and cleaved into an α- and a β-chain, which are connected by five symmetrical disulfide bonds. Recently, it has been demonstrated that besides the predominant sCLU, rare intracellular CLU forms are expressed in stressed cells. Since these for…
Responsability in management of the early stages in clinical evaluation of oral-facial traumatic events
2019
Obiettivi Scopo del presente lavoro è esaminare gli eventi traumatici oro-facciali e i loro effetti e individuare linee e schemi comportamentali e un linguaggio clinico e medico-legale appropriato che aiutino a identificare con immediatezza l’evento traumatico e i suoi postumi, e una corretta gestione dello stesso, in modo consono alle esigenze assicurative e/o giudiziarie, oltre che strettamente cliniche. Si vuole, inoltre, sottolineare l’importanza clinica e medico-legale della prima visita. Materiali e metodi I diversi aspetti dell’argomento sono esaminati sia da un punto di vista clinico che medico legale. Attraverso l’analisi delle diverse tipologie di trauma e degli schemi procedurali…
Bounds for the relative n-th nilpotency degree in compact groups
2009
The line of investigation of the present paper goes back to a classical work of W. H. Gustafson of the 1973, in which it is described the probability that two randomly chosen group elements commute. In the same work, he gave some bounds for this kind of probability, providing information on the group structure. We have recently obtained some generalizations of his results for finite groups. Here we improve them in the context of the compact groups.