Search results for "44"

Synthesis of novel fluorinated building blocks via halofluorination and related reactions.

2020

A study exploring halofluorination and fluoroselenation of some cyclic olefins, such as diesters, imides, and lactams with varied functionalization patterns and different structural architectures is described. The synthetic methodologies were based on electrophilic activation through halonium ions of the ring olefin bonds, followed by nucleophilic fluorination with Deoxo-Fluor®. The fluorine-containing products thus obtained were subjected to elimination reactions, yielding various fluorine-containing small-molecular entities.

Ring-opening metathesis of some strained bicyclic systems; stereocontrolled access to diolefinated saturated heterocycles with multiple stereogenic c…

2018

Ring-opening metathesis (ROM) of various unsaturated, constrained bicyclic ring systems has been investigated with the use of commercial ruthenium-based catalysts. Starting from various cyclodienes, the corresponding derived bicyclic lactone, lactam, and isoxazoline derivatives were submitted to ROM under ethenolysis. These functionalized, strained bicyclic systems afforded novel highly-functionalized diolefinated heterocyclic scaffolds in ROM reactions with stereocontrol, through the conservation of the configuration of the stereogenic centers of the starting compounds.

¿Quién decide qué y cómo? el conflicto en torno a la participación ciudadana en el contexto del desarrollo de la iniciativa urbana: Cuenca-San Antón …

2018

This article describes the main results of an ethnographic study on citizen participation carried out in the context of the development of the Urban Initiative (2007-2015): Cuenca-Barrio de San Antón. Managed by the City Council of Cuenca and financed by the European Regional Development Funds (FEDER) under the Ministry of Economy and Finance at the Government of Spain The results of the research show how in the context of the application of neoliberal policies, citizen participation becomes the trigger for new conflicts between institutions and citizens. In this sense, it is worth noting how, in practice, institutions in their capacity as experts and not willing to dis-empower themselves, …

A tale of two palaces and a city: Valencia, 1238-1460

2013

Este artículo estudia las relaciones entre el palacio del Real (Palau del Real), la residencia de los reyes de Aragón en Valencia y la Casa de la Ciudad (Casa de la Ciutat o Sala del Consell) desde la conquista cristiana hasta el final del reinado de Alfonso V el Magnánimo. Durante dos siglos la corte real y el gobierno de la ciudad manifestaron la alianza, la rivalidad y los conflictos a través de la arquitectura y la decoración de sus respectivas sedes. Los emplazamientos, las grandes salas, las capillas con reliquias y las fiestas cívicas desempeñaron un papel notable como instrumentos al servicio tanto de los reyes y sus oficiales como de los consejeros municipales. Aunque ambos palacio…

La commissione di estinzione anticipata non rileva ai fini della verifica di usurarietà

2022

Partial thioamide scan on the lipopeptaibiotic trichogin GA IV. Effects on folding and bioactivity

2012

Backbone modification is a common chemical tool to control the conformation of linear peptides and to explore potentially useful effects on their biochemical and biophysical properties. The thioamide, ψ[CS-NH], group is a nearly isosteric structural mimic of the amide (peptide) functionality. In this paper, we describe the solution synthesis, chemical characterization, preferred conformation, and membrane and biological activities of three, carefully selected, peptide analogues of the lipopeptaibiotic [Leu11-OMe] trichogin GA IV. In each analogue, a single thioamide replacement was incorporated. Sequence positions near the N-terminus, at the center, and near the C-terminus were investigated…

Copolymerization of Ethylene with Selected Vinyl Monomers Catalyzed by Group 4 Metal and Vanadium Complexes with Multidentate Ligands: A Short Review

2021

This paper gives a short overview of homogeneous post-metallocene catalysts based on group 4 metal and vanadium complexes bearing multidentate ligands. It summarizes the catalytic behavior of those catalysts in copolymerization of ethylene with 1-olefins, with styrenic monomers and with α,ω-alkenols. The review is focused on finding correlations between the structure of a complex, its catalyst activity and comonomer incorporation ability, as well as the microstructure of the copolymer chains.

El lujo cambiante. El vestido y la difusión de las modas en la Corona de Aragón (siglos XIII-XV)

2015

La apariencia física de las persona era ya en la Baja Edad Media el primer indicativo de su condición social, pero en un período mucho más urbanizado e interconectado que los anteriores, el refinamiento de la indumentaria se convirtió en un hecho con unas connotaciones económicas, políticas y culturales de gran calado. El mismo incremento de la movilidad social llevó además a que no bastara con invertir grandes sumas en la propia imagen, sino que fuera necesario estar atento a los cambios de eso que llamamos “moda”, cuyos orígenes se suelen situar en estos momentos en los que las clases dominantes tradicionales buscaban nuevos elementos de diferenciación frente a los advenedizos. Todo ello …

Predicting needlestick and sharps injuries in nursing students: Development of the SNNIP scale

2020

© 2020 The Authors. Nursing Open published by John Wiley & Sons Ltd. Aim: To develop an instrument to investigate knowledge and predictive factors of needlestick and sharps injuries (NSIs) in nursing students during clinical placements. Design: Instrument development and cross-sectional study for psychometric testing. Methods: A self-administered instrument including demographic data, injury epidemiology and predictive factors of NSIs was developed between October 2018–January 2019. Content validity was assessed by a panel of experts. The instrument's factor structure and discriminant validity were explored using principal components analysis. The STROBE guidelines were followed. Results: E…

Ferro- and Antiferromagnetic Interactions in Oxalato-Centered Inverse Hexanuclear and Chain Copper(II) Complexes with Pyrazole Derivatives.

2021

Two novel copper(II) complexes of formulas {[Cu(4-Hmpz)4][Cu(4-Hmpz)2(µ3-ox-κ2O1,O2:κO2′:κO1′)(ClO4)2]}n (1) and {[Cu(3,4,5-Htmpz)4]2[Cu(3,4,5-Htmpz)2(µ3-ox-κ2O1,O2:κO2′:κO1′)(H2O)(ClO4)]2[Cu2(3,4,5-Htmpz)4(µ-ox-κ2O1,O2:κ2O2′,O1′)]}(ClO4)4·6H2O (2) have been obtained by using 4-methyl-1H-pyrazole (4-Hmpz) and 3,4,5-trimethyl-1H-pyrazole (3,4,5-Htmpz) as terminal ligands and oxalate (ox) as the polyatomic inverse coordination center. The crystal structure of 1 consists of perchlorate counteranions and cationic copper(II) chains with alternating bis(pyrazole)(µ3-κ2O1,O2:κO2′:κO1′-oxalato)copper(II) and tetrakis(pyrazole)copper(II) fragments. The crystal structure of 2 is made up of perchlorat…