Search results for "44"
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Parecer de un mathematico valenciano sobre el cometa que se ha dejado ver en las noches de enero y febrero de este año 1744 ....
Precedeix al tít.: `[Creu de Malta Grav. xil. en text Text a 1 col. - Reclams Sign.: [ ]2
Discurso sobre el phenomeno aparecido en nuestro Orizonte el dia 7. de Enero de 1744
Banda i ornaments tip. sobre el tít Reclams
Juicio, y pronostico del nuevo cometa, que apareció sobre nuestro Orizonte el dia siete de Enero de este año de 1744
1744
Sense portada, títol pres del inici del text Lloc d'impressió pres del colofó Predeceix al títol: Cristus Caplletra ornada a la primera página
Validation of a questionnaire for young women to assess knowledge, attitudes and behaviors towards cervical screening and vaccination against HPV in …
2014
Background: Despite knowledge about HPV may be an important determinant for vaccine acceptance and uptake, only few studies have assessed HPV-related knowledge in young females. The aim of this study was to assess the reliability and validity of the questionnaire, in Italian women ≥18 years old, as a tool to examine knowledge, attitudes and behaviors towards screening and vaccination against HPV and reliable source of information. Methods: The questionnaire was administered to 30 girls in anonymous, voluntary and self -administered form with close-ended type of questions, except for the socio-demographic characteristics. It was composed in 3 sections for a total of 69 items. Participation i…
Computational Approaches: Drug Discovery and Design in Medicinal Chemistry and Bioinformatics
2021
To date, computational approaches have been recognized as a key component in drug design and discovery workflows. Developed to help researchers save time and reduce costs, several computational tools have been developed and implemented in the last twenty years. At present, they are routinely used to identify a therapeutic target, understand ligand–protein and protein–protein interactions, and identify orthosteric and allosteric binding sites, but their primary use remains the identification of hits through ligand-based and structure-based virtual screening and the optimization of lead compounds, followed by the estimation of the binding free energy. The repurposing of an old drug for the tr…
New Anti-Neoplastics Obtained by a Molecular Connectivity Method
2000
Molecular Connectivity is a method, which allows to discriminate different pharmacological activities on the basics of numeric parameters of the molecules in study, related with specific and exclusive indexes. In the present study, we propose two potentially anti-neoplasic compounds: tricromil and zomepirac, by analyzing more than a hundred different chemicals.
Sample Preparation to Determine Pharmaceutical and Personal Care Products in an All-Water Matrix: Solid Phase Extraction
2020
© 2020 by the authors.
A conformationally adaptive macrocycle : conformational complexity and host–guest chemistry of zorb[4]arene
2018
Large amplitude conformational change is one of the features of biomolecular recognition and is also the basis for allosteric effects and signal transduction in functional biological systems. However, synthetic receptors with controllable conformational changes are rare. In this article, we present a thorough study on the host–guest chemistry of a conformationally adaptive macrocycle, namely per-O-ethoxyzorb[4]arene (ZB4). Similar to per-O-ethoxyoxatub[4]arene, ZB4 is capable of accommodating a wide range of organic cations. However, ZB4 does not show large amplitude conformational responses to the electronic substituents on the guests. Instead of a linear free-energy relationship, ZB4 foll…
Household Leverage and Fiscal Multipliers
2011
We study the size of fiscal multipliers in response to a government spending shock under different household leverage conditions in a general equilibrium setting with search and matching frictions. We allow for different levels of household indebtedness by changing the intensive margin of borrowing (loan-to-value ratio), as well as the extensive margin, defined as the number of borrowers over total population. The interaction between the consumption decisions of agents with limited access to credit and the process of wage bargaining and vacancy posting delivers two main results: (a) higher initial leverage makes it more likely to find output multipliers higher than one; and (b) a positive g…