Search results for "44"
showing 10 items of 1507 documents
A Broad Iron Line in the Chandra High Energy Transmission Grating Spectrum of 4U 1705-44
2005
We present the results of a Chandra 30 ks observation of the low-mass X-ray binary and atoll source 4U 1705-44. Here we concentrate on the study of discrete features in the energy spectrum at energies below ~3 keV, as well as on the iron Kalpha line, using the High Energy Transmission Grating Spectrometer on board the Chandra satellite. Below 3 keV, three narrow emission lines are found at 1.47, 2.0, and 2.6 keV. The 1.47 and 2.6 keV lines are probably identified with Lyalpha emission from Mg XII and S XVI, respectively. The identification of the feature at ~2.0 keV is uncertain because of the presence of an instrumental feature at the same energy. The iron Kalpha line at ~6.5 keV is found …
Non-cooperative Equilibria of Fermi Systems With Long Range Interactions
2019
We define a Banach space $\mathcal{M}_{1}$ of models for fermions or quantum spins in the lattice with long range interactions and explicit the structure of (generalized) equilibrium states for any $\mathfrak{m}\in \mathcal{M}_{1}$. In particular, we give a first answer to an old open problem in mathematical physics - first addressed by Ginibre in 1968 within a different context - about the validity of the so-called Bogoliubov approximation on the level of states. Depending on the model $\mathfrak{m}\in \mathcal{M}_{1}$, our method provides a systematic way to study all its correlation functions and can thus be used to analyze the physics of long range interactions. Furthermore, we show tha…
Communication: The absolute shielding scales of oxygen and sulfur revisited
2015
Copyright 2015 AIP Publishing. This article may be downloaded for personal use only. Any other use requires prior permission of the author and AIP Publishing. The following article appeared in Journal of Chemical Physics 2015, 142 and may be found at http://dx.doi.org/10.1063/1.4913634 We present an updated semi-experimental absolute shielding scale for the 17O and 33S nuclei. These new shielding scales are based on accurate rotational microwave data for the spin–rotation constants of H2 17O [Puzzarini et al., J. Chem. Phys. 131, 234304 (2009)], C17O [Cazzoli et al., Phys. Chem. Chem. Phys. 4, 3575 (2002)], and H2 33S [Helgaker et al., J. Chem. Phys. 139, 244308 (2013)] corrected both for v…
Multiband Photometry of the Blazar PKS 0537-441: A Major Active State in December 2004 - March 2005
2005
Multiband VRIJHK photometry of the Blazar PKS 0537-441 obtained with the REM telescope from December 2004 to March 2005 is presented. A major period of activity is found with more than four magnitudes variability in the V filter in 50 days and of 2.5 in 10 days. In intensity and duration the activity is similar to that of 1972 reported by Eggen (1973), but it is much better documented. No clear evidence of variability on time-scale of minutes is found. The spectral energy distribution is roughly described by a power-law, with the weaker state being the softer.
A self-consistent approach to the reflection component in 4U 1705-44
2010
High-resolution spectroscopy has recently revealed in many neutron-star Low-Mass X-ray binaries that the shape of the broad iron line observed in the 6.4-6.97 keV range is consistently well fitted by a relativistically smeared line profile. We show here spectral fitting results using a newly developed self-consistent reflection model on XMM-Newton data of the LMXB 4U 1705-44 during a period when the source was in a bright soft state. This reflection model adopts a blackbody prescription for the shape of the impinging radiation field, that we physically associate with the boundary layer emission. © 2010 American Institute of Physics.
Torus computed tomography
2020
We present a new computed tomography (CT) method for inverting the Radon transform in 2D. The idea relies on the geometry of the flat torus, hence we call the new method Torus CT. We prove new inversion formulas for integrable functions, solve a minimization problem associated to Tikhonov regularization in Sobolev spaces and prove that the solution operator provides an admissible regularization strategy with a quantitative stability estimate. This regularization is a simple post-processing low-pass filter for the Fourier series of a phantom. We also study the adjoint and the normal operator of the X-ray transform on the flat torus. The X-ray transform is unitary on the flat torus. We have i…
Current Evidence, Challenges, and Opportunities of Physiologically Based Pharmacokinetic Models of Atorvastatin for Decision Making
2021
Atorvastatin (ATS) is the gold-standard treatment worldwide for the management of hypercholesterolemia and prevention of cardiovascular diseases associated with dyslipidemia. Physiologically based pharmacokinetic (PBPK) models have been positioned as a valuable tool for the characterization of complex pharmacokinetic (PK) processes and its extrapolation in special sub-groups of the population, leading to regulatory recognition. Several PBPK models of ATS have been published in the recent years, addressing different aspects of the PK properties of ATS. Therefore, the aims of this review are (i) to summarize the physicochemical and pharmacokinetic characteristics involved in the time-course o…
Physiologically-Based Pharmacokinetic/Pharmacodynamic Model of MBQ-167 to Predict Tumor Growth Inhibition in Mice
2020
MBQ-167 is a dual inhibitor of the Rho GTPases Rac and Cdc42 that has shown promising results as an anti-cancer therapeutic at the preclinical stage. This drug has been tested in vitro and in vivo in metastatic breast cancer mouse models. The aim of this study is to develop a physiologically based pharmacokinetic/pharmacodynamic (PBPK-PD) model of MBQ-167 to predict tumor growth inhibition following intraperitoneal (IP) administration in mice bearing Triple Negative and HER2+ mammary tumors. PBPK and Simeoni tumor growth inhibition (TGI) models were developed using the Simcyp V19 Animal Simulator. Our developed PBPK framework adequately describes the time course of MBQ-167 in each of the mo…
Plant Occurring Flavonoids as Modulators of the Aryl Hydrocarbon Receptor
2021
International audience; The aryl hydrocarbon receptor (AhR) is a transcription factor deeply implicated in health and diseases. Historically identified as a sensor of xenobiotics and mainly toxic substances, AhR has recently become an emerging pharmacological target in cancer, immunology, inflammatory conditions, and aging. Multiple AhR ligands are recognized, with plant occurring flavonoids being the largest group of natural ligands of AhR in the human diet. The biological implications of the modulatory effects of flavonoids on AhR could be highlighted from a toxicological and environmental concern and for the possible pharmacological applicability. Overall, the possible AhR-mediated harmf…
Identification of Volatile Compounds in Blackcurrant Berries: Differences Among Cultivars
2021
Berries of blackcurrant are known to produce a strong flavor. Some previous studies have reported that a given cultivar of blackcurrant can produce berries with a specific profile of volatile compounds. For the Burgundy region in France, the Noir de Bourgogne cultivar is especially important because it is the main ingredient of a liquor with a designation of origin. The aim of the present study was to characterize the volatile fractions of berries from 15 cultivars in order to explore the possibility of using different cultivars for liquor production. The plants were cultivated under the same conditions and harvested in the same year. The volatile fractions of the harvested berries were ana…