Search results for "451"

Ro 15-4513 Antagonizes Alcohol-Induced Sedation in Mice Through αβγ2-type GABAA Receptors

2011

Ethyl alcohol (ethanol) has many molecular targets in the nervous system, its potency at these sites being low compared with those of sedative drugs. This has made it difficult to discover ethanol’s binding site(s). There are two putative binding sites at gamma-aminobutyric acid (GABA) type A receptor subtypes for the proposed ethanol antagonist Ro 15-4513, the established gamma2 subunit-dependent benzodiazepine site and the recently reported delta subunit-dependent Ro 15-4513/ethanol binding site. Here, we aimed at clarifying the in vivo role of Ro 15-4513 at these two sites. We found that the antagonism of ethanol actions by Ro 15-4513 in wildtype mice was dependent on the test: an open f…

IGR J17451-3022: a dipping and eclipsing low mass X-ray binary

2016

In this paper, we report on the available X-ray data collected by INTEGRAL, Swift, and XMM-Newton during the first outburst of the INTEGRAL transient IGR J17451-3022, discovered in 2014 August. The monitoring observations provided by the JEM-X instruments on-board INTEGRAL and the Swift/XRT showed that the event lasted for about 9 months and that the emission of the source remained soft for the entire period. The source emission is dominated by a thermal component (kT~1.2 keV), most likely produced by an accretion disk. The XMM-Newton observation carried out during the outburst revealed the presence of multiple absorption features in the soft X-ray emission that could be associated to the p…

Die Embryologie im Spannungsfeld zwischen Tradition und Empirie.

1991

Already in classical antiquity people dealt with the principle of formation, developing different theories. Researchers in the renaissance, working in the conflict zone between tradition and experience, tried to prove one or the other of these theories by the means of new observations, especially of chicken development. Aldrovandi was the first to see the real principle of formation of the hen's egg, i. e. the blastodisc, but he didn't recognize the importance of his discovery due to his close adherence to Aristotle in the theoretical field. Fabricius even thought that traditional knowledge was of more importance than his own excellent observations. Parisano was the first to succeed in maki…

The Pomar Codex (ca, 1590): plants and animals of the old world and from the Hernandez expedition to America.

1992

Abstract<title> RIASSUNTO </title>Si descrive un codice illustrato (ca. 1590), donato dal re Filippo II a Honorato Pomar, professore di medicina botanica all'Università di Valencia, e ora conservato nella biblioteca della stessa universita. Tale codice contiene 218 acquarelli di piante e animali del Vecchio Continente e provenienti dalla spedizione nelle Americhe di Hernandez (1571-1577). Inoltre, l'articolo si sofferma brevemente sull'interesse di Filippo II per la storia naturale, sulla spedizione di Hernandez e sulla cattedra di botanica medica all'universita di Valencia nel corso del sedicesimo secolo. Infine, si discute dell'identita dell'autore delle illustrazioni e dei te…

Effective characterization of the phase and intensity profiles of asymmetrically distorted light pulses in optical fiber systems

2009

International audience; We address the problem of characterization of light pulses that propagate in long-haul high-bit-rate optical communication systems under strongly perturbed conditions. We show that the conventional technique for characterization of the phase and intensity profile of such pulses becomes qualitatively inconsistent when the pulse's profile is asymmetrically distorted with respect to its center of mass. We resolve these inconsistencies by partially reformulating the conventional technique by means of appropriate pulse parameters, which we call upgraded parameters, that allow a fair characterization of the intensity and phase of all types of light pulses, including those …

El pintor Ignacio Pinazo Camarlench en su centenario. Introducción

2016

Application of the SKYRAD Improved Langley plot method for the in situ calibration of CIMEL Sun-sky photometers

2007

The in situ procedure for determining the solar calibration constants, originally developed for the PREDE Sun-sky radiometers and based on a modified version of the Langley plot, was applied to a CIMEL instrument located in Valencia, Spain, not integrated into AERONET. Taking into account the different mechanical and electronic characteristics of the two radiometers, the method was adapted to the characteristics of the CIMEL instrument. The iterative procedure for the determination of the solar calibration constants was applied to a 3-year data set. The results were compared with the two sets of experimental calibration constants determined during this period using the standard Langley plot…

Interaspecific chemical variability and highlighting of chemotypes of leaf essential oils from Ravensara aromatica Sonnerat, a tree endemic to Madaga…

2006

Ravensara aromatica Sonnerat is a tree endemic to Madagascar. The essential oil extracted from the leaves is used in aromatherapy. Previous chemical studies have generated some confusion with regard to the chemical composition of this essential oil. In order to eliminate this uncertainty, we undertook a systematic evaluation of the chemical composition of essential oils from leaves of this species. The study focused on 28 individual samples formally identified as R. aromatica. The essential oils were obtained by hydrodistillation and analysed by GC and GC–MS. It was possible to distinguish four groups of trees through principal components analysis and agglomerative hierarchical clustering a…