Search results for "45"
showing 10 items of 1896 documents
CYP2D6 genotype and adjuvant tamoxifen: meta-analysis of heterogeneous study populations.
2013
The International Tamoxifen Pharmacogenomics Consortium was established to address the controversy regarding cytochrome P450 2D6 (CYP2D6) status and clinical outcomes in tamoxifen therapy. We performed a meta-analysis on data from 4,973 tamoxifen-treated patients (12 globally distributed sites). Using strict eligibility requirements (postmenopausal women with estrogen receptor-positive breast cancer, receiving 20 mg/day tamoxifen for 5 years, criterion 1); CYP2D6 poor metabolizer status was associated with poorer invasive disease-free survival (IDFS: hazard ratio = 1.25; 95% confidence interval = 1.06, 1.47; P = 0.009). However, CYP2D6 status was not statistically significant when tamoxifen…
Association Between CYP2D6 Polymorphisms and Outcomes Among Women With Early Stage Breast Cancer Treated With Tamoxifen
2009
Context The growth inhibitory effect of tamoxifen, which is used for the treatment of hormone receptor–positive breast cancer, is mediated by its metabolites, 4-hydroxytamoxifen and endoxifen. The formation of active metabolites is catalyzed by the polymorphic cytochrome P450 2D6 (CYP2D6) enzyme. Objective To determine whether CYP2D6 variation is associated with clinical outcomes in women receiving adjuvant tamoxifen. Design, Setting, and Patients Retrospective analysis of German and US cohorts of patients treated with adjuvant tamoxifen for early stage breast cancer. The 1325 patients had diagnoses between 1986 and 2005 of stage I through III breast cancer and were mainly postmenopausal (9…
Prediction of paclitaxel resistance in breast cancer: is CYP1B1*3 a new factor of influence?
2008
This article focuses on the recent findings by Marsh and colleagues, and also discusses recent findings with regards to breast cancer. Taxanes are amongst the most active agents in the treatment of breast cancer. However, many tumors are intrinsically resistant. Therefore, it would be an enormous progress, if factors could be identified that reliably differentiate between taxane-sensitive and -resistant patients. Marsh and colleagues analyzed the CYP1B1*3 (Val432Leu) polymorphism in patients with high-risk stage III and IV breast cancer, who received dose-intense paclitaxel in combination with doxorubicin and cyclophosphamide. They report for the first time that patients with two leucine al…
The taint of torture and the brazilian legal system
2019
In Brazil, the practice of torture intertwines deeply with its own history. The literature on the subject has had a greater intensification on its registers during the Dictatorial Regime (1964 to 1985). In spite of the Brazilian Constitution of 1988, Brazil only makes efforts to investigate the crimes of torture of this period to comply with the provisions of the United Nations in 2011. Within this scenario, the NationalTruth Commission (Law 12.528, of November 2011) was created with the purpose of clarifying the facts and circumstances of cases concerning human rights violations, as well as the Law on Access to Information (Law 12.527 of November 2011), which have regulated the constitutio…
Le mineur de 13 ans au seuil de la responsabilité pénale
2019
International audience
Employment sector and pay gaps: Genetic and environmental influences
2012
This paper examines the role of genetic factors and shared environment in explaining the choice of working in the public sector and public-private sector pay gaps. The analyses are done using data for Finnish twins that span the period from 1990 to 2004. The data are based on two sources. The first data are Finnish Twin Cohort conducted by Department of Public Health in University of Helsinki. These data have been matched with the Finnish Longitudinal Employer-Employee Data (FLEED) kept by Statistics Finland. The standard behavioural genetics decomposition and DF (DeFries and Fulker 1985) analyses indicate that public sector employment is broadly influenced by the genetic factors by around …
Management of chronic musculoskeletal pain in veterans: a systematic review
2021
Background and aim of the work. Veterans are military with health problems due to military conditions. The improved body armor and operational conditions has reduced the number of deaths, but increased the number of veterans with severe injuries, affected by musculoskeletal pain and associated syndromes, such as post-traumatic stress disorder. Multimodal approaches are considered in USA the gold standard for the treatment of these problems, while in Europe and Italy the data are unknown. The aim of this review was to describe and summarize multimodal therapeutic approaches that apply to the veteran population for chronic musculoskeletal pain and relate syndromes management. Methods. A compr…
Arquitectura renacentista "inacabada" de Jerónimo Quijano y su integración en determinados templos de origen gòtico
2014
Jerónimo Quijano fue un arquitecto español que destacó durante la etapa del Renacimiento Pleno en España en el tercio central del siglo XVI. Los edificios seleccionados principalmente son: iglesia de Santiago de Orihuela –Alicante– e iglesia de Santa María del Salvador de Chinchilla –Albacete–. En ambos se construyó una nueva cabecera renacentista e integrada en una nave gótica preexistente y en el caso de haber sido “acabadas” íntegramente con el criterio del maestro serían sin duda ejemplos claves del Renacimiento español. En Orihuela se percibe la necesidad de “descubrir” visualmente el magnífico arco de triunfo romano que hace de portada de la nueva cabecera renacentista, sugiriendo así…
Zvaigžņotā Debess: 2017, Rudens (237)
2017
Contents: “ZVAIGŽŅOTĀ DEBESS” FORTY YEARS AGO: U.Dzērvītis. Dispute on Hubble’s Constant Value (abridged) ; E.Mūkins. Ten «Venera»’s: Devices, Journeys and Results (abridged) ; DEVELOPMENTS in SCIENCE: K.Schwartz. New Discoveries in the Orion Molecular Cloud Complex ; SPACE RESEARCH and EXPLORATION: J.Jaunbergs. Salty Emanations of Enceladus ; R.Misa. Voyager: the Longest and Farthest ; OBSERVATORIES and INSTRUMENTS: J.Kuzmanis. Dragon Looks at the Sky ; K.Salmiņš. On ILRS Technical Workshop 2017 in Riga ; CONFERENCES and MEETINGS: M.Sudārs. Trends of Space Infrastructure Development in Europe ; M.Gills. Congress of European Planetary Science 2017 in Riga ; FLASHBACK: N.Cimahoviča. On Whirl…
Plantar Pressure Differences Between Nordic Walking Techniques
2017
Abstract High plantar pressure has been associated with increased risk of injury. The characteristics of each physical activity determine the load on the lower limbs. The influence of Nordic Walking (NW) technique on plantar pressure is still unknown. The aim of this study was to analyze the differences between plantar pressure during NW with the Diagonal technique (DT) versus Alpha technique (AT) and compare them with the pressure obtained during normal walking (W). The normality and sphericity of the plantar pressure data were checked before performing a two-way repeated measures ANOVA in order to find differences between speeds (preferred, fast) and the gait (NW, W) as within-subject fac…