Search results for "45"
showing 10 items of 1896 documents
External Versus Internal Metabolic Activation of Polycyclic Aromatic Compounds in Mutagenicity Tests: A Comparison Using Heterologous Expression Syst…
1996
Abstract Benzo[a]pyrene-trans-7,8-dihydrodiol was virtually non-mutagenic to Chinese hamster V79p cells, but was strongly mutagenic to a V79-derived cell line expressing cytochrome P450 1A1, when the cells were exposed separately. In mixed cultures of these two cell types, it showed about 50 % of the mutagenic activity in V79p cells, compared to that observed in the enzyme-proficient cell line, indicating an efficient intercellular transfer of the active metabolite. The benzylic alcohols 1-hydroxymethylpyrene and 6-hydroxymethylbenzo[a]-pyrene were weakly mutagenic to Salmonella typhimurium TA1538 in the absence of a metabolic activation system, but were potent mutagens to a TA1538-derived …
Mechanisms involved in lipid accumulation and apoptosis induced by 1-nitropyrene in Hepa1c1c7 cells
2011
International audience; 1-Nitropyrene (1-NP) is a nitro-polycyclic aromatic hydrocarbon (nitro-PAH) present in diesel exhaust and bound to particular matter in urban air. We show that 1-NP and the referent PAH benzo(a)pyrene (BP) induce apoptosis and a lipid accumulation dependent on cytochrome P450 1A1-metabolites in mouse hepatoma cells, whereas 1-amino-pyrene had no effect. The caspase inhibitor, N-benzyloxycarbonyl-Val-Ala-Asp(O-Me) fluoromethyl ketone (Z-VAD-fmk), inhibits 1-NP-induced apoptosis, but failed to alter 1-NP-triggered lipid accumulation determined by Nile red staining. We further show that cholesterol and fatty acid contents are modified after nitro-PAH exposure and that 1…
User behavior in Smart and Sustainable Offices (SSO)
2017
Smart and Sustainable Offices (SSO) require synergies between technologies and users behaviors. The sociotechnical approach considers users’ motives, attitudes, cognitions and behaviors when designing work environments. This note will describe those phenomena in office environments. It will also present a set of tools to assess those phenomena and will provide guidelines to improve them.
The case of equality in the dichotomy of Mohammadi-Oh
2017
If $n \geq 3$ and $\Gamma$ is a convex-cocompact Zariski-dense discrete subgroup of $\mathbf{SO}^o(1,n+1)$ such that $\delta_\Gamma=n-m$ where $m$ is an integer, $1 \leq m \leq n-1$, we show that for any $m$-dimensional subgroup $U$ in the horospheric group $N$, the Burger-Roblin measure associated to $\Gamma$ on the quotient of the frame bundle is $U$-recurrent.
Development of an individualized familiarization method for vertical jumps
2013
OBJETIVO: Propor um método de familiarização individualizado para saltos verticais e verificar o seu efeito na variabilidade intrassujeito. MÉTODOS: Cinquenta e três homes (média ± DP; idade 23,5 ± 3,3 anos; estatura 1,76 ± 0,08 m; massa 72,8 ± 8,6 kg; percentual de gordura 12,9 ± 5,2%) realizaram sucessivos saltos até atingir o nível de estabilidade proposto. Após 48 h este processo era repetido e a estabilidade entre dias era verificada, se necessário, mais sessões eram realizadas. O nível de estabilidade foi determinado por um teste z, com intervalo de confiança de 95%. Após o processo de familiarização, duas sessões experimentais adicionais foram realizadas para determinar a confiabilid…
Los procedimientos civiles para recuperar la posesión de inmuebles ocupados
2021
The purpose of this article is to analyse the differnt civil process of the Civil Procedure Law that can be used for the recovery of illegally occupied properties: eviction for precarious, injunction to recover possession and action action for the protection of registered property rights. Special attention is paid to the new procedure of rapid recovery of possession that has been created by Law 5/2018 amending the classic injunction to regain possession.
Claves vertebradoras del modelo de justicia en el siglo XXI
2021
The 21st Century presents a dynamic, international, digital, changing, agile, and fast Society, that demands an adequated Justice System. The Incorporation due to Globalization of Keys such a Supranationality, Internationalization, Efficiency, Feminization, Technology, Algorithms and Artificial Intelligence, are involved in the changes of the new look of Justice.
La suprema giurisdizione nella Sardegna moderna. Travagli della Real Audiencia (1564-1651)
2019
The institution of the Real Audiencia in the kingdom of Sardinia since the 1560s is part of a wider process which saw the rise and development of royal supreme courts of justice in several European countries of the early modern period. In fact, major State formation processes all around Europe required that monarchs increased their control on local authorities and that new increasingly centralised systems of judicial review gained precedence over all particular jurisdictions, feudal as well as municipal. This brought about a dramatic transformation in the field of criminal law enforcement and administration of justice.
Fruits and vegetables protect against the genotoxicity of heterocyclic aromatic amines activated by human xenobiotic-metabolizing enzymes expressed i…
2010
Heterocyclic aromatic amines (HAAs) can be formed during the cooking of meat and fish at elevated temperatures and are associated with an increased risk for cancer. On the other hand, epidemiological findings suggest that foods rich in fruits and vegetables can protect against cancer. In the present study three teas, two wines, and the juices of 15 fruits and 11 vegetables were investigated for their protective effect against the genotoxic effects of 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP). To closely mimic the enzymatic activation of these HAAs in humans, genetically engineered V79 Chinese hamster fibroblasts were employed tha…
Involvement of an Alkane Hydroxylase System of Gordonia sp. Strain SoCg in Degradation of Solid n-Alkanes▿
2010
ABSTRACT Enzymes involved in oxidation of long-chain n -alkanes are still not well known, especially those in Gram-positive bacteria. This work describes the alkane degradation system of the n -alkane degrader actinobacterium Gordonia sp. strain SoCg, which is able to grow on n -alkanes from dodecane (C 12 ) to hexatriacontane (C 36 ) as the sole C source. SoCg harbors in its chromosome a single alk locus carrying six open reading frames (ORFs), which shows 78 to 79% identity with the alkane hydroxylase (AH)-encoding systems of other alkane-degrading actinobacteria. Quantitative reverse transcription-PCR showed that the genes encoding AlkB (alkane 1-monooxygenase), RubA3 (rubredoxin), RubA4…