Search results for "45"

Nurses' perception of the oncology patient's death: a qualitative study

2021

Death is one of the basic theme with which nurses are faced, and for which it is hard for them to prepare deeply and sincerely. The difficulties in handling the emotional burden can cause them to develop negative feelings towards life and clinical practice, so that it affects their caregiving capacity and the quality of care provided.To explore nurses' perceptions facing the death of a hospitalized oncology patient.Qualitative phenomenological study. The sample of nurses was recruited at IRCCS (Scientific Institute for Research and Healthcare) in Rome, a hospice in Latina and a hospice in Rieti. The data were collected by means of focus groups. The semi-structured interviews featuring three…

The role of Aurora-A inhibitors in cancer therapy

2007

Recently, new chemotherapy agents which target the non-structural components of mitosis have been developed. An important protein involved in several mitotic phases is the Aurora-A protein. By means of the phosphorylation of different substrates, Aurora-A regulates the correct development of the various phases of mitosis. The kinase activity of this protein makes Aurora-A an excellent candidate as an oncogene. The first data of Aurora-A involvement in cancer regarded the identification of Aurora-A overexpression in primary breast and colon tumour samples. With regard to the predictive role of Aurora-A, it has been shown that its overexpression disrupts the spindle checkpoint activated by pa…

Archiviazione o cestinazione delle pseudo notizie di reato: un problema ancora irrisolto

2000

L'Autrice affronta il problema della c.d. cestinazione del pubblico ministero, quale strada alternativa a quella ortodossa dell'archiviazione. Sono messi in risalto i rischi connessi a un potere autonomo, privo di un qualsiasi controllo, né giurisdizionale né gerarchico, in capo al pubblico ministero di cestinare quelle informative che prima facie non sembrano rivestire alcuna rilevanza penale. Potere che sembra trovare un riconoscimento nell'istituzione del registro, il c.d. mod. 45, ove il titolare dell'azione penale è tenuto a iscrivere le c.d. pseudo notizie di reato. La violazione del principio di obbligatorietà sancito dall'art. 112 Cost. sembra potersi paventare laddove sia lasciata …

Sequence variability in the Babesia bigemina merozoite surface antigen GP45 gene among Mexican and Italian isolates

2008

Fluorescence-Based Screening of Cytochrome P450 Activities in Intact Cells

2013

Fluorimetric methods to assess cytochrome P450 (P450) activities that do not require metabolite separation have been developed. These methods make use of non- or low-fluorescent P450 substrates that produce highly fluorescent metabolites in aqueous solutions. The assays are based on the direct incubation of intact cells in culture with appropriate fluorogenic probe substrates, followed by fluorimetric quantification of the product formed and released into incubation medium. We describe a battery of fluorescence assays for rapid measurement of the activity of nine P450s involved in drug metabolism. For each individual P450 activity the probe showing the best properties (highest metabolic rat…

In vitro evaluation of bacteriocinlike inhibitory substances produced by lactic acid bacteria isolated during traditional sicilian cheese making

2016

Bacteriocins are antimicrobial proteins produced by bacteria that inhibit with a bactericidal or bacteriostatic mode of action, the growth of other bacteria. Many lactic acid bacteria (LAB) produce a high diversity of different bacteriocins. Bacteriocinogenic LAB are generally recognized as safe (GRAS) and useful to control the frequent development of pathogens and spoilage microorganisms; for this reason they are commonly used as starter cultures in food fermentations. In this study, the authors describe the results of a screening on 699 LAB isolated from wooden vat surfaces, raw milk and traditional Sicilian cheeses, for the production of bacteriocin-like inhibitory substances (BLIS), by …

Improvement of balance in a 7-year-old child through a six-week learning programme

2018

Given that human beings are constantly subjected to equilibration processes, developing basic perceptual motor skills, especially balance, is important. The main purpose of this study is the validation of the tasks and the progression of activities that form the learning programme for balance development in a six-week didactic unit of 12 sessions (2 sessions per week), for 6 to 9 year old children (1st, 2nd, and 3rd grade of elementary school in Brazil). The changes in balance after applying the programme are also analysed through a new measuring protocol using baropodometry. Although the session was put into practice in a class of 28 children, data were extracted from a 7-year-old child. T…

The efficacy of balneotherapy, mud therapy and spa therapy in patients with osteoarthritis: an overview of reviews.

2021

Osteoarthritis is a degenerative disease considered a leading cause of functional disability. Its treatment is based on a combination of pharmacological and non-pharmacological interventions, but the role of these latter is still debated. This overview of systematic reviews aimed at evaluating the short-term efficacy of different thermal modalities in patients with osteoarthritis. We searched PubMed, Scopus, CINHAL, Web of Science, ProQuest and the Cochrane Database of Systematic Reviews from inception until October 2020, with no language restrictions. We selected the following outcomes a priori: pain, stiffness and quality of life. Seventeen systematic reviews containing 27 unique relevant…

Dominus qui incepit ipse perficiat: exhortaciones de fray Josep Mercader a las monjas dominicas del monasterio de Montesión en Barcelona (1740-1745)

2016

Resumen: De entre la galeria de personajes interesantes que nos ofrece el convento dominicano de Santa Catalina virgen y martir de Barcelona en el siglo XVIII destaca fray Josep Mercader (profesion 1720-1779). Un apartado importante aunque «intimo» de su obra lo constituyen las once breves exhortaciones que entre los anos 1740-1745 dirigio a las monjas dominicas del monasterio barcelones de Montesion con ocasion de las ceremonias de recepcion y profesion. En estos 20 folios podemos encontrar el discurso que un dominico cualificado dirigio a las monjas de clausura de su orden en dos momentos tan significativos de su trayectoria religiosa. Palabras clave: Josep Mercader, Dominicos (frailes y …

Autonomous Operation of Stationary Battery Energy Storage Systems—Optimal Storage Design and Economic Potential

2021

Global warming requires a changeover from fossil fuel based to renewable energy sources on the electrical supply side and electrification of the demand side. Due to the transient nature of renewables and fluctuating demand, buffer capacities are necessary to compensate for supply/demand imbalances. Battery energy storage systems are promising. However, the initial costs are high. Repurposing electric vehicle batteries can reduce initial costs. Further, storage design optimization could significantly improve costs. Therefore, a battery control algorithm was developed, and a simulation study was performed to identify the optimal storage design and its economic potential. The algorithm used is…