Search results for "45"

Antigüedad clásica y cultura nobiliaria en la España de finales del siglo XVIII. Autores y ediciones greco-romanas en la biblioteca de José Alvarez d…

2019

This article analyzes the reception of the classical world in the Spanish nobiliary culture at the end of the 18th century. Our objective is materialized through the study of the Greco-Roman books present in the unpublished catalog of the library of José Álvarez de Toledo, 11th Marqués de villafranca. From the examination of the authors and the different editions conserved by the aristocrat, the work tries to examine the influence of the classical world and its actuality in the development of the most advanced nobiliary culture of eighteenth- century Spain.

La Biblioteca dei Re d'Aragona in Napoli

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Phosphorylation of cytochromes P450: First discovery of a posttranslational modification of a drug-metabolizing enzyme

2005

Cytochromes P450 (CYP) are important components of xenobiotic-metabolizing monooxygenases (CYP-dependent monooxygenases). Their regulation by induction, most commonly by transcriptional activation, mediated by xenobiotics, normally substrates of the corresponding CYP, is well known and has been widely studied. Our team has discovered an additional important regulation of xenobiotic-metabolizing CYPs pertaining to posttranslational modification by phosphorylation. Individual CYPs are phosphorylated by different protein kinases, leading to CYP isoenzyme-selective changes in the metabolism of individual substrates and consequent drastic changes in the control of genotoxic metabolites. Best stu…

Association of obesity with proteasomal gene polymorphisms in children.

2013

The aim of this study was to ascertain possible associations between childhood obesity, its anthropometric and clinical parameters, and three loci of proteasomal genes rs2277460 (PSMA6c.-110C>A), rs1048990 (PSMA6c.-8C>G), and rs2348071 (PSMA3c. 543+138G>A) implicated in obesity-related diseases. Obese subjects included 94 otherwise healthy children in Latvia. Loci were genotyped and then analyzed using polymerase chain reactions, with results compared to those of 191 nonobese controls.PSMA3SNP frequency differences between obese children and controls, while not reaching significance, suggested a trend. These differences, however, proved highly significant (P<0.002) in the subset…

Juan de Sariñena y Luis Beltrán, dos iconos de la espiritualidad en el arte valenciano: apreciaciones a propósito del lienzo conservado en el Museo I…

2014

Relacion de los libros legados á la Universidad literaria de Valencia por el Sr. D. Francisco Javier Borrull, Oidor de la Audiencia territorial de la…

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Indice de los libros de D. Francisco Javier Borrull

Ms En nota a la fi, es relacionen objectes també llegats, com ara "un monetario..." Tít. en portadella: Indice de los libros de D. Fran[cis]co Javier Borrull

The Catalytic Mechanism of Steroidogenic Cytochromes P450 from All-Atom Simulations: Entwinement with Membrane Environment, Redox Partners, and Post-…

2019

Cytochromes P450 (CYP450s) promote the biosynthesis of steroid hormones with major impact on the onset of diseases such as breast and prostate cancers. By merging distinct functions into the same catalytic scaffold, steroidogenic CYP450s enhance complex chemical transformations with extreme efficiency and selectivity. Mammalian CYP450s and their redox partners are membrane-anchored proteins, dynamically associating to form functional machineries. Mounting evidence signifies that environmental factors are strictly intertwined with CYP450s catalysis. Atomic-level simulations have the potential to provide insights into the catalytic mechanism of steroidogenic CYP450s and on its regulation by e…

Clinical features of the impact of eating disorders on the results of 13C-methacetin breath test for assessment of liver function in girls with anore…

2019

Introduction: This study was designed to assess the influence of chosen aspects of anorexia nervosa eating disorders (AN ED) on 13C-methacetin breath test (MBT) results. Material and methods: We investigated a group of 81 girls, including 41 patients with confirmed diagnosis of AN ED. The study group was divided in two subgroups. According to the DSM-5 classification, 25 underweight patients met the criteria of anorexia nervosa (AN), and 16 girls with BMI value > 5th percentile for age and sex were diagnosed as atypical anorexia nervosa (AAN). Laboratory tests assessing the liver function and the MBT were performed in all the participants of the study. Results: In all healthy females the va…

SNPs and taxane toxicity in breast cancer patients

2014

Aim: In order to identify genetic variants associated with taxanes toxicity, a panel with 47 SNPs in 20 genes involved in taxane pathways was designed. Patients & methods: Genomic DNA of 113 breast cancer patients was analyzed (70 taking docetaxel, 43 taking paclitaxel). Results: Two SNPs associated with docetaxel toxicity were identified: CYP3A4*1B with infusion-related reactions; and ERCC1 Gln504Lys with mucositis (p ≤ 0.01). Regarding paclitaxel toxicity: CYP2C8 HapC and CYP2C8 rs1934951 were associated with anemia; and ERCC1 Gln504Lys with neuropathy (p ≤ 0.01). Conclusion: Genes involved in DNA repair mechanisms and reactive oxygen species levels influence taxane toxicity in cance…