Search results for "45"
showing 10 items of 1896 documents
Ethoxyresorufin-O-deethylase induction potency of polychlorinated diphenyl ethers in H4IIE rat hepatoma cells
1996
Polychlorinated diphenyl ethers (PCDEs) are structurally similar to polychlorinated biphenyls (PCBs), and some PCDE congeners have been reported to cause toxic responses similar to those caused by some of the non-ortho-substituted PCBs, which are mediated by the aryl hydrocarbon receptor (AhR). Twenty-nine PCDEs were tested for their potency as AhR agonists relative to 2,3,7,8-tetrachlorodibenzo-p-dioxin (2,3,7,8-TCDD) by measuring their ability to induce the cytochrome P-450 1A1-associated enzyme activity, ethoxyresorufin-O-deethylase (EROD), in the H4IIE rat hepatoma cell bioassay. All PCDE congeners tested were found to be inactive as EROD inducers except for PCDE 156, which was a weak E…
Effects of eight weeks of physical training on physical performance and heart rate variability in children
2017
Kraama, Liisa. 2013. Effects of eight weeks physical training on physical performance and heart rate variability in children. University of Jyvaskyla, Department of Biology of Physical Activity. Master’s Thesis in Exercise Physiology. 52 pp. Physical activity and aerobic capacity have decreased among children and adolescents during the last decades. Physically active adults have been shown to have higher heart rate variability (HRV) than less active adults. In adults training-induced changes in physical performance have been shown to be related to increase in HRV, especially in high frequency component (HF), which is a marker of parasympathetic activity. The purpose of this study was to exa…
Overlapping self-affine sets of Kakeya type
2009
We compute the Minkowski dimension for a family of self-affine sets on the plane. Our result holds for every (rather than generic) set in the class. Moreover, we exhibit explicit open subsets of this class where we allow overlapping, and do not impose any conditions on the norms of the linear maps. The family under consideration was inspired by the theory of Kakeya sets.
Strategies to In Vitro Assessment of Major Human CYP Enzyme Activities by Using Liquid Chromatography Tandem Mass Spectrometry
2008
At the early stage of drug discovery, thousands of new chemical entities (NCEs) may be screened before a single candidate can be identified for development. Determining the role of CYP enzymes in the metabolism of a compound and evaluating the effect of NCEs on human CYP activities are key issues in pharmaceutical development as they may explain inter-subject variability, drug-drug interactions, non-linear pharmacokinetics and toxic effects. Reliable methods for determining enzyme activities are needed to characterize an individual CYP enzyme and to obtain a tool for the evaluation of its role in drug metabolism in humans. Different liquid chromatography tandem mass spectrometry methodologi…
Cloning and training collective intelligence with generative adversarial networks
2021
Industry 4.0 and highly automated critical infrastructure can be seen as cyber‐physical‐social systems controlled by the Collective Intelligence. Such systems are essential for the functioning of the society and economy. On one hand, they have flexible infrastructure of heterogeneous systems and assets. On the other hand, they are social systems, which include collaborating humans and artificial decision makers. Such (human plus machine) resources must be pre‐trained to perform their mission with high efficiency. Both human and machine learning approaches must be bridged to enable such training. The importance of these systems requires the anticipation of the potential and previously unknow…
Blow-up collocation solutions of nonlinear homogeneous Volterra integral equations
2011
In this paper, collocation methods are used for detecting blow-up solutions of nonlinear homogeneous Volterra-Hammerstein integral equations. To do this, we introduce the concept of "blow-up collocation solution" and analyze numerically some blow-up time estimates using collocation methods in particular examples where previous results about existence and uniqueness can be applied. Finally, we discuss the relationships between necessary conditions for blow-up of collocation solutions and exact solutions.
Behavior of four main dairy pathogenic bacteria during manufacturing and ripening of pecorino siciliano cheese
2020
Background: Consumption of raw cheese may be associated with different diseases. This study aimed to evaluate behavior of four pathogenic bacteria during manufacture and ripening of Protected Designation of Origin (PDO) Pecorino Siciliano cheese.
 Methods: The experimental cheese groups were inoculated with pathogenic bacteria, including Escherichia coli O157, Listeria monocytogenes, Salmonella Enteritidis, and Staphylococcus aureus. The cheese making processes were monitored from milk curdling until 3 months ripened cheeses and the levels of Lactic Acid Bacteria (LAB) and the four dairy pathogens were evaluated by plate counts. Randomly Amplified Polymorphic DNA (RAPD)-Polymerase Chai…
Polymorphism of cytochrome P450 (CYP) genes and response to chemiotherapy in patients with colorectal cancer (CRC)
2014
Background: Genes coding for the cytochrome P450 (CYP) enzyme system implied in antineoplastic drug metabolism pathways are highly polymorphic. This may influence both carcinogen metabolism and drug pharmacodynamics modifying their therapeutic efficacy and side effects. Methods: We investigated the influence of genetic polymorphisms of CYP enzymes: rs1799853 (CYP2C9), rs35742686 (CYP2D), rs5030655 (CYP2D6/3), rs2740574 (CYP3A4/1) rs776746 (CYP3A5) on the response of chemotherapy and clinical outcomes, in a group of 56 patients affected by sporadic CRC, treated with the standard protocols. A total of 44 patients were in complete remission after treatment, 12 had persistence of the disease. P…
Goal-setting strategy and psychological differences in marathon runners compared by gender
2019
Prior to a marathon race, we conducted a cross sectional study with 122 male and 18 female recreational runners at the Expo. Demographic information, running experience, competition level, training details, goal and finishing times, and PODIUM questionnaire on psychological state variables were collected. Motivation, training volume, experience, and relative performance were comparable between male and female marathon runners. However, men were more ambitious and perceived higher self-confidence and fitness, although overestimated their goals ( M dif = -10.4, SD = 16.7] minutes, p < .001). Women perceived higher social support, reported higher anxiety levels, were more accurate in their est…
The use of complementary therapies for chronic pain in Italian hospices.
2013
Scopo: Sebbene ci sia un incremento dell’utilizzo delle Terapie Complemntari (CT) in Europa, ancora è poco noto l’utilizzo di esse negli hospice italiani per il trattamento del dolore cronico. Questa indagine ha lo scopo di descrivere la diffusione delle CT e le loro diverse tipologie impiegate per il trattamento del dolore cronico nel setting assistenziale delle Cure Palliative. Metodi. È stata realizzata una indagine on-line su tutto il campione dei 16 hospices presenti nel territorio della Regione Lazio, utilizzando un questionario adattato e validato per descriverne utilizzo e barriere dell’uso delle CT per il trattamento del dolore cronico oncologico e benigno. Risultati: Il tasso di r…