Search results for "45"

Effects of primary- and secondary-treated bleached kraft mill effluents on the immune system and physiological parameters of roach.

2000

The present study was designed to examine, whether, effluents from a modern pulp and paper mill using elemental chlorine-free/total chlorine-free (ECF/TCF) bleaching, exert effects on the immune system of fish and, in addition, to relate these findings to physiological parameters known to be affected by bleached kraft-mill effluents (BKME). Roach (Rutilus rutilus) were exposed in laboratory conditions to primary- or secondary-treated effluent from a pulp and paper mill. In order to study their capability to respond to foreign antigens they were immunised with bovine gamma-globulin (BGG) prior to exposure. The number of anti-BGG antibody-secreting cells (ASC) and the number of immunoglobulin…

"Il Gattopardo", "Le Guépard", "Der Leopard", "The Leopard"

2009

Oratio ad Sacrosanctum Oecumenicum Concilium Tridentinum, qua de ecclesiae auctoritate, et imitandis apostolis disseritur habita per... Gasparem A' F…

1563

Sign.: A4, B2

Pharmacogenetic considerations for optimizing tacrolimus dosing in liver and kidney transplant patients

2013

The introduction of tacrolimus in clinical practice has improved patient survival after organ transplant. However, despite the long use of tacrolimus in clinical practice, the best way to use this agent is still a matter of intense debate. The start of the genomic era has generated new research areas, such as pharmacogenetics, which studies the variability of drug response in relation to the genetic factors involved in the processes responsible for the pharmacokinetics and/or the action mechanism of a drug in the body. This variability seems to be correlated with the presence of genetic polymorphisms. Genotyping is an attractive option especially for the initiation of the dosing of tacrolim…

Effect of CYP3A5*3 on kidney transplant recipients treated with tacrolimus: a systematic review and meta-analysis of observational studies

2014

The highly variable pharmacokinetics of tacrolimus can hamper the optimal management of kidney transplant patients. This variability has been attributed to the genetic polymorphism of CYP3A5 6986A>G, but the evidence is not clear. We conducted a meta-analysis of studies evaluating the effect of CYP3A5 polymorphism on kidney transplant recipients with tacrolimus plasma concentration divided by daily dose per body weight (C/D) and clinical outcomes. We searched in MEDLINE and EMBASE. We found evidence suggesting a significantly lower C/D among CYP3A5*1 allele carriers compared with carriers of the CYP3A5*3/*3 genotype at weeks 1 and 2, and months 1, 3, 6 and 12. We demonstrated that the expre…

Metric Lie groups admitting dilations

2019

We consider left-invariant distances $d$ on a Lie group $G$ with the property that there exists a multiplicative one-parameter group of Lie automorphisms $(0, \infty)\rightarrow\mathtt{Aut}(G)$, $\lambda\mapsto\delta_\lambda$, so that $ d(\delta_\lambda x,\delta_\lambda y) = \lambda d(x,y)$, for all $x,y\in G$ and all $\lambda>0$. First, we show that all such distances are admissible, that is, they induce the manifold topology. Second, we characterize multiplicative one-parameter groups of Lie automorphisms that are dilations for some left-invariant distance in terms of algebraic properties of their infinitesimal generator. Third, we show that an admissible left-invariant distance on a Lie …

Guanine 6-O-Methylation Pattern within the Dioxin Responsive Element of theCYP1A1 Enhancer Shows Two Critical Guanines for AhR/ARNT Binding

2006

The core-recognition motif for TCDD-liganded AhR/ARNT complex of the dioxin-responsive element (DRE) contains four guanine residues, three on the antisense (5'-T T / A GCGTG-3') and one on the sense (5'-CACGC A / T A-3') strand. It has been reported that, in methylation-protection and methylation-interference assays, the TCDD-liganded AhR/ARNT contacts all four guanine residues. On the other hand, it is known that some anticancer drugs, and various environmental and workplace chemicals, including strongly human carcinogenic nitrosoamines, lead to the highly miscoding 6-O-methylation of guanine. In the present study, we have investigated whether specific methylation of guanine at the 6-O-pos…

The Original Position and the Rationality of Primo Levi's Shame

2016

Contrary to what he expected, Primo Levi didn’t experience his life after being released from Auschwitz as cheerful and light-hearted. He – like many other survivors – was haunted by an obscure and solid anguish that he finally identified as springing from a sense of shame or guilt in front of those who were exterminated in the Lager. Levi was unable to either acknowledge his shame as rational or reject it as irrational. This looks, though, like a rather unstable situation calling for some further elucidation. I will thus examine Levi’s shame in light of the dominant conception of practical deliberation and, more specifically, in view of the the role that John Rawls ascribes to the original…

Segunda parte de las epístolas familiares del ... señor don Antonio de gueuara ... obispo que fue de mondoñedo ...

1549

Sig. A10, B-H8, I12, K-N8, O6. - Data d'impr. al colofó "Acabose lunes a ocho dias del mes de julio. Año... de mil y quinientos y quarenta y nueue años" V.II. - CXVIII [i.e.CXVI] f. Escut imperial i escuts episcopals de l'autor a la port. - Capitals grav. Port. amb orla xil., a dos tintes. - Lletra gòtica. - Tots els f. orlats. - Erates de fol., del f.X passa al IX

Libro primero d[e] las epístolas familiares del ... señor don Antonio de Gueuara ... obispo d[e] Mo[n]doñedo ...

1549

Sig. [ ]2, A-O8, P6. - Data d'impr."a nueue dias del mes de março. Año de mil y quinientos y quarenta y nueue Años" I. - CXV [i.e.CXX] f. Escut imperial i escuts episcopals de l'autor a la port. - Capitals grav. Port. amb orla xil., a dos tintes. - Lletra gòtica. - Text amb alguna postil·la marginal. - Tots els f. orlats. - Errates de fol. CXV per CXX