Search results for "45"

Characterization of disease-specific cellular abundance profiles of chronic inflammatory skin conditions from deconvolution of biopsy samples

2019

Background Psoriasis and atopic dermatitis are two inflammatory skin diseases with a high prevalence and a significant burden on the patients. Underlying molecular mechanisms include chronic inflammation and abnormal proliferation. However, the cell types contributing to these molecular mechanisms are much less understood. Recently, deconvolution methodologies have allowed the digital quantification of cell types in bulk tissue based on mRNA expression data from biopsies. Using these methods to study the cellular composition of the skin enables the rapid enumeration of multiple cell types, providing insight into the numerical changes of cell types associated with chronic inflammatory skin c…

Structure–activity relationships, and drug metabolism and pharmacokinetic properties for indazole piperazine and indazole piperidine inhibitors of RO…

2007

ROCK has been implicated in many diseases ranging from glaucoma to spinal cord injury and is therefore an important target for therapeutic intervention. In this study, we have designed a series of 1-(4-(1H-indazol-5-yl)piperazin-1-yl)-2-hydroxy(or 2-amino) analogs and a series of 1-(4-(1H-indazol-5-yl amino)piperidin-1-yl)-2-hydroxy(or 2-amino) inhibitors of ROCK-II. SR-1459 has IC50 = 13 nM versus ROCK-II while the IC50s for SR-715 and SR-899 are 80 nM and 100 nM, respectively. Many of these inhibitors, especially the 2-amino substituted analogs for both series, are modest/potent CYP3A4 inhibitors as well. However, a few of these inhibitors (SR-715 and SR-899) show strong selectivity for R…

Reja Bredberija romāna “451 grāds pēc Fārenheita” personāžu vizuālo tēlu izstrāde

2015

Pēdējos gados ir strauji pieaugušas tehnoloģiskās iespējas, veidojot visdažādākos koncepta dizainus. Tādu jaunu programmu pieejamība kā, piemēram, Photoshop, sniedz jebkuram interesentam iespējas realizēt pat visfantastiskākās savas idejas ātri, efektīgi un foto-reālistiski. Darba mērķis ir noskaidrot zinātniskās fantastikas savienojamības iespējas koncepta dizainā. Teorētiskajā daļā apskatīta literatūra par zinātnisko fantastiku, Reja Bredberija daiļrade, kā arī Reja Bredberija 1953.gadā izdotais romāns “451 grāds pēc Fārenheita”, koncepta dizaina principi, process un metodes. Pētnieciskajā daļā kā darba izpētes objekts tika analizētas koncepta dizaina grāmatas, kas balstītas uz zinātnisko…

Compliance of the Covid 19 restructions of the Republic of Latvia with the Article 45 of TFEU on freedom of movement of workers

2021

Bakalaura darba tēma ir Latvijas Republikas Covid-19 ierobežojumu atbilstība LESD 45.pantam par darba ņēmēju pārvietošanās brīvību. Pētījuma mērķis ir noskaidrot, kuri Covid-19 ierobežojumi nesamērīgi ierobežo darbinieku pārvietošanās brīvību darba pienākumu izpildē un neatbilst LESD 45.pantam. Darba uzdevums ir izvērtēt ierobežojumus saskaņā ar diskriminācijas un nediskriminējošu ierobežojumu aizlieguma, samērīguma un piesardzības principu, kā arī izteikt ieteikumus nesamērīgo ierobežojumu novēršanai, samērīgi līdzsvarojot indivīda tiesības un sabiedrības intereses. Darbā secināts, ka darba ņēmēju brīvas kustības ierobežojumiem sabiedrības veselības apsvērumu dēļ jābūt tādiem, kas nepiecie…

La intervenció d’Antoni Dalmau (†1453) a les galeries del claustre de la catedral de Barcelona

2016

Ramos Herranz, I.: La protección de los menores de edad en la publicidad infantil de juguetes, Thomson Reuters Aranzadi, 2019.

2021

Some factors affecting the removal of lead(II) ions from aqueous solution by porous hydroxyapatite: relationships between surface and adsorption prop…

2006

A porous hydroxyapatite (p-HAp) was prepared and employed for the removal of lead(II) ions at different concentrations from aqueous solution to determine the adsorption properties of p-HAp and compare them with those of a commercial hydroxyapatite (CAp) sample. The kinetic data obtained indicated that the adsorption performances of the adsorbents depended both on their specific surface area and crystallinity. Complexation of the Pb(II) ion on the adsorbent surface favoured the dissolution of hydroxyapatites characterized by a Ca/Pb molar ratio in the 0.85–1.5 range. The maximum adsorption capacity of p-Hap for Pb(II) ions at 30 ± 2°C was 2.30 mmol/g relative to 1.38 mmol/g for the commercia…

Akadēmiskā Dzīve, 44.krājums

2007

Māteru Juris kā sava laika ideologs: studiju darbs

1943

Statistical Thermodynamics of Polymer Quantum Systems

2011

Polymer quantum systems are mechanical models quantized similarly as loop quantum gravity. It is actually in quantizing gravity that the polymer term holds proper as the quantum geometry excitations yield a reminiscent of a polymer material. In such an approach both non-singular cosmological models and a microscopic basis for the entropy of some black holes have arisen. Also important physical questions for these systems involve thermodynamics. With this motivation, in this work, we study the statistical thermody- namics of two one dimensional polymer quantum systems: an ensemble of oscillators that describe a solid and a bunch of non-interacting particles in a box, which thus form an ideal…